Taurine in Development and Nutrition

Gaull, Gerald E.; Rassin, David K.

doi:10.1002/9780470720554.ch17

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Antioxidant Interventions1

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2018

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Cited by 9 publications

(1 citation statement)

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“…Taurine is a nonessential sulfur amino acid synthesized from sulfur-containing amino acids methionine and cysteine. Taurine, whose levels are maintained by unidirectional maternal to fetal placental transport by the taurine transporter (TauT) (69), is essential for proper fetal development (41,74). Growth-restricted human fetuses have reduced taurine levels caused by diminished TauT activity (30,106).…”

Section: Antioxidant Interventionsmentioning

confidence: 99%

Oxidative Stress, Intrauterine Growth Restriction, and Developmental Programming of Type 2 Diabetes

2018

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Section: Antioxidant Interventionsmentioning

confidence: 99%

Oxidative Stress, Intrauterine Growth Restriction, and Developmental Programming of Type 2 Diabetes

2018

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Taurine and the Oxidative Metabolism of Cysteine

Huxtable

1986

Biochemistry of Sulfur

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Farriol¹,

Venereo²,

Rossello³

et al. 2002

Amino Acids

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This study determines the effects of taurine (Tau) on phagocytosis of polymorphonuclear neutrophils (PMN) isolated from normal subjects (n = 41) and severely burned patients (n = 20). Phagocytosis was measured by nitroblue of tetrazolium (NBT) reduction in samples with and without latex bead stimulation. Taurine was added at doses of 0.2, 0.4, 0.8 and 1.6 mM to stimulated samples. In control cells there were statistically significant increases in phagocytosis after addition of Tau 0.8 mM and 1.6 mM to as compared to samples without Tau addition (295 +/- 23% and 330 +/- 35% vs. 248 +/- 18%; mean +/- S.E.; p < 0.05). A statistically significant increase in phagocytosis was observed in cells from the burned population after addition of Tau 1.6 mM (288 +/- 38% vs. 198 +/- 13%; mean +/- S.E.; p < 0.05). No changes in phagocytosis were found in cells from a subgroup of burn patients (n = 13) followed over 7, 15 and 21 days. These results indicate that taurine supplementation in vitro at doses of 0.8 to 1.6 mM improves the phagocytic capacity of neutrophils in healthy subjects and in patients with severe burn injury, mainly when neutrophil function is unaltered.

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Taurine in Development and Nutrition

Cited by 9 publications

References 83 publications

Oxidative Stress, Intrauterine Growth Restriction, and Developmental Programming of Type 2 Diabetes

Oxidative Stress, Intrauterine Growth Restriction, and Developmental Programming of Type 2 Diabetes

Taurine and the Oxidative Metabolism of Cysteine

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