Taurine Enhances Proliferation and Promotes Neuronal Specification of Murine and Human Neural Stem/Progenitor Cells

Pasantes‐Morales, Herminia; Ramos‐Mandujano, Gerardo; Hernández-Benítez, Reyna

doi:10.1007/978-3-319-15126-7_36

Cited by 14 publications

(9 citation statements)

References 40 publications

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“…Although the biological role of taurine is not at all clear, some studies suggest that it may be a compound involved in the nervous system, being especially necessary for brain development [ 8 ]. This suggestion is supported by the fact that high levels of taurine have been found in the fetal brain [ 9 ]. In addition, taurine displays many other biological roles, such as the marking of certain toxic intermediaries or the regulation of intracellular calcium levels.…”

Section: Introductionmentioning

confidence: 89%

Effects of the Usage of l-Cysteine (l-Cys) on Human Health

2018

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This review summarizes recent knowledge about the use of the amino acid l-Cysteine (l-Cys) through diet, nutritional supplements or drugs with the aim to improve human health or treat certain diseases. Three databases (PubMed, Scopus, and Web of Science) and different keywords have been used to create a database of documents published between 1950 and 2017 in scientific journals in English or Spanish. A total of 60,885 primary publications were ultimately selected to compile accurate information about the use of l-Cys in medicine and nutritional therapies and to identify the reported benefits of l-Cys on human health. The number of publications about the use of l-Cys for these purposes has increased significantly during the last two decades. This increase seems to be closely related to the rise of nutraceutical industries and personalized medicine. The main evidence reporting benefits of l-Cys usage is summarized. However, the lack of accurate information and studies based on clinical trials hampers consensus among authors. Thus, the debate about the role and effectiveness of supplements/drugs containing l-Cys is still open.

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Section: Introductionmentioning

confidence: 89%

Effects of the Usage of l-Cysteine (l-Cys) on Human Health

2018

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“…Further, the main content of Sarasvata Ghrita is goat's milk, which contains taurine, a type of amino acid which stimulates proliferation and new neuron formation to sustain learning and memory. [15][16][17] Sarasvata Ghrita contains drugs which are having Medhya Prabhava. 18 It increases the Satvika properties of Mana which acts as Samprapti Vighatana, i.e., breaking of psychopathology to help in the treatment of cognitive deficit.…”

Section: Safety Profilementioning

confidence: 99%

Clinical Efficacy and Safety of Sarasvata Ghrita in the Management of Cognitive Deficit–A Prospective Open Label Study

Sharma¹,

Rao²,

Sahu³

et al. 2018

Journal of Research in Ayurvedic Sciences

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“…In a culture of human fetal neurons (Chen et al, 1998) and of neural stem cells from the developing mouse brain, taurine induces proliferation where it acts through ERK1/2 signaling pathway (Shivaraj et al, 2012). It has also been shown that taurine promotes proliferation and specification of neural progenitor cells (Hernandez-Benitez et al, 2010b, 2013Pasantes-Morales et al, 2015). Moreover prolonged taurine treatment showed an increase of intracellular Ca 21 concentration that induces gene expression (Wang et al, 2015).…”

Section: Taurinementioning

confidence: 99%

“…Finally, the presence of taurine in the embryonic cortex is well established and several studies imply that taurine is involved in neurogenesis and neuronal migration based on the different models described below: In an animal model of intrauterine growth restriction, taurine supplementation in pregnant rats reduces cell apoptosis and improves cerebral neurogenesis in the fetal brain (Liu et al, ). In a culture of human fetal neurons (Chen et al, ) and of neural stem cells from the developing mouse brain, taurine induces proliferation where it acts through ERK1/2 signaling pathway (Shivaraj et al, ). It has also been shown that taurine promotes proliferation and specification of neural progenitor cells (Hernandez‐Benitez et al, 2010b, 2013; Pasantes‐Morales et al, ). Moreover prolonged taurine treatment showed an increase of intracellular Ca 2+ concentration that induces gene expression (Wang et al, ). Analysis from fetal rat brain extracts have shown that prenatal taurine administration allows neuroprotection and neuroproliferation associated with an increase in mRNAs coding for PKA, CREB, and GDNF are increased in fetal rat brains (Chen et al, ). Taurine deficiency has been studied in cats and rhesus monkeys.…”

Section: Introductionmentioning

confidence: 99%

The building of the neocortex with non‐hyperpolarizing neurotransmitters

Ascenzi¹,

Bony

2017

Developmental Neurobiology

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The development of the neocortex requires the synergic action of several secreted molecules to achieve the right amount of proliferation, differentiation, and migration of neural cells. Neurons are well known to release neurotransmitters (NTs) in adult and a growing body of evidences describes the presence of NTs already in the embryonic brain, long before the generation of synapses. NTs are classified as inhibitory or excitatory based on the physiological responses of the target neuron. However, this view is challenged by the fact that glycine and GABA NTs are excitatory during development. Many reviews have described the role of nonhyperpolarizing GABA at this stage. Nevertheless, a global consideration of the inhibitory neurotransmitters and their downstream signaling during the embryonic cortical development is still needed. For example, taurine, the most abundant neurotransmitter during development is poorly studied regarding its role during cortical development. In the light of recent discoveries, we will discuss the functions of glycine, GABA, and taurine during embryonic cortical development with an emphasis on their downstream signaling. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 77: 1023-1037, 2017.

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Taurine Enhances Proliferation and Promotes Neuronal Specification of Murine and Human Neural Stem/Progenitor Cells

Cited by 14 publications

References 40 publications

Effects of the Usage of l-Cysteine (l-Cys) on Human Health

Effects of the Usage of l-Cysteine (l-Cys) on Human Health

Clinical Efficacy and Safety of Sarasvata Ghrita in the Management of Cognitive Deficit–A Prospective Open Label Study

The building of the neocortex with non‐hyperpolarizing neurotransmitters

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