Taste Evaluation by Electronic Tongue and Bioavailability Enhancement of Efavirenz

Rao, Monica R. P.; Bhutada, Kirti; Kaushal, Pauroosh

doi:10.1208/s12249-018-1277-8

Cited by 11 publications

(2 citation statements)

References 37 publications

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“…In addition to the aforementioned dosage forms, other solid formulations have also been investigated, including extrudates from hot-melt extrusion [96][97][98], (mini-)tablets [99,100], orodispersible and mucoadhesive films [101,102], nanofibers from co-axial electrospinning [103,104], and SNEDDS-formulations [105].…”

Section: Other Solid Dosage Formsmentioning

confidence: 99%

“…Still, all of them were described to be initially dissolved in aqueous solutions from 15 to 60 s. Except for the mini-tablets, which were ground in a mortar first [99], each dosage form was put into the dissolution liquid unmodified. The applied dissolution media were aqueous potassium chloride solutions [97,99,103,105], buffer solutions at pH 6.8 [96], or deionized water [98,102] in volumes of 25-100 mL. Whether the samples were filtered prior to the following e-tongue measurements was not always mentioned.…”

Section: Other Solid Dosage Formsmentioning

confidence: 99%

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Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients

Steiner,

Meyer,

Immohr

et al. 2024

Pharmaceutics

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In this review, we aim to highlight the advantages, challenges, and limitations of electronic tongues (e-tongues) in pharmaceutical drug development. The authors, therefore, critically evaluated the performance of e-tongues regarding their qualification to assess peroral formulations containing bitter active pharmaceutical ingredients. A literature search using the keywords ‘electronic’, ‘tongue’, ‘bitter’, and ‘drug’ in a Web of Science search was therefore initially conducted. Reviewing the publications of the past decade, and further literature where necessary, allowed the authors to discuss whether and how e-tongues perform as expected and whether they have the potential to become a standard tool in drug development. Specifically highlighted are the expectations an e-tongue should meet. Further, a brief insight into the technologies of the utilized e-tongues is given. Reliable protocols were found that enable (i) the qualified performance of e-tongue instruments from an analytical perspective, (ii) proper taste-masking assessments, and (iii) under certain circumstances, the evaluation of bitterness.

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