Tartrazine induced changes in physiological and biochemical parameters in Swiss albino mice, Mus musculus

Hossain, Mohammad Salim; Neshe, Shamme Akter; Rashid, Md. Mamun Or; Amin, Mohammad Tohidul; Hussain, Md. Saddam

doi:10.12991/marupj.319304

Cited by 14 publications

(13 citation statements)

References 16 publications

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“…Moreover, both hepatic immunohistochemical research of COX-2 expression and histological structures had been notably altered, supplementation with Vitamin E partly protected against the recorded hepatic biochemical and histological changes caused by exposure to 300 mg/kg of TZ. The findings of this study were consistent with the results of different researches that postulated physiological and biochemical 22 , immunological 23 and histological 24 , severe changes in the liver after administration of tartrazine. Moreover, as reported by Demirkol, et al 25 reported the a dministration of tartrazine at the dose of 7.5mg/kg daily for 30 days lead to an extreme histopathological and cellular change of rat liver.…”

Section: Discussionsupporting

confidence: 92%

Ameliorating Effect of Vitamin E on Liver Damage Caused by Administering Tartrazine in Male Mice

Al-Shaikh

2021

Asian Journal of Pharmaceutical Research and Health Care

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Tartrazine is a common artificial food and pharmaceutical additive and has become a part of daily intake values. However, the actual daily intake is much higher than the recommended value. A higher intake is shown to exhibit carcinogenic, mutagenic, and allergic effects. The present work aimed to research whether antioxidant vitamin E (Vit E) therapy would impact liver damage induced by Tartar-Zine (TZ). Twenty-eight mice were used in this experimental study. Mice were categorized into four groups; group (A) in which mice served as control were orally administered distilled water for 28 days. Group (B) in which mice administered daily 100 mg/kg vitamin E orally for 28 days. Group (C) in which mice administered daily 300 mg/kg tartrazine dissolved in distilled water orally for 28 days. Group (D), mice received orally both 100mg/kg vitamin E and 300mg/kg tartrazine concomitantly for 28 days. Biochemical parameters in serum including liver function enzymes aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP), glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione S-transferase (GST) and catalase (CAT) had been inspected. Histological and immunological studies were done including Cyclooxygenase-2 (COX-2). Results showed that TZ treatment initiates hepatic disorders indicated by elevation of liver enzymes and oxidative stress markers in treated mice. Oral administration of Vit E diminished the activities of ALP, AST, and ALT compared to treated mice. Besides, Vit E effectively reduced oxidative stress as indicated by elevated GSH, SOD, GST, CAT, and decreased MDA. Histologically, TZ+Vit E delineated moderate potential improvement of hepatic tissue architecture. Immunologically revealed that TZ+Vit E treated mice showed reduction in COX-2 immuno-expression in hepatic cords sinusoids and hepatocytes versus TZ group. In conclusion, treatment with Vit E could improve all deviated biochemical, immunological, and histological changed induced by tartrazine consumption.

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Section: Discussionsupporting

confidence: 92%

Ameliorating Effect of Vitamin E on Liver Damage Caused by Administering Tartrazine in Male Mice

Al-Shaikh

2021

Asian Journal of Pharmaceutical Research and Health Care

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“…According to Arefin et al significantly increased levels of CRE and TG are reported in Swiss mice, after applying tartrazine dose 400 mg/kg b.w. by oral gavage [52].…”

Section: Resultsmentioning

confidence: 99%

Protective effect of blackthorn fruits (Prunus spinosa) against tartrazine toxicity development in albino Wistar rats

et al. 2019

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Background Tartrazine (Yellow 5 or E102) is a synthetic food dye able to modify perception and behavior, causing agitation, confusion, rhinitis and can produce hyperactivity syndrome in children when is combined with benzoates. Additionally, it can trigger oxidative stress which consequently generates metabolic disorders. Therefore, the study was designed to evaluate the harmful effects of the food additive tartrazine and to observe beneficial properties of blackthorn fruits ( Prunus spinosa ) on the blood and organs of albino Wistar rats. Materials and methods This study was carried out on 20 mature Wistar rats, randomly divided into four groups of five animals. Over the course of the experiment, the control group received only food and drinking water, group I received 75 mg of tartrazine dissolved in (250 ml) water group II was given 75 mg of tartrazine and 200 mg of dried blackthorn fruit powder 200 mg dissolved simultaneously in (250 ml) of tartrazine-water mixture (aiming to reduce the tartrazine toxicity) and group III received a higher dose of tartrazine (100 mg) in (250 ml) of water. Results At the end of the experiment, values regarding kidney and liver weight were significantly increased, while the weight of the spleen was slightly decreased compared with the weight of the control group. Biochemical and hematological assays, of the blood samples show that the addition of tartrazine in the diet of rats caused significant changes in all biochemical and hematological parameters of the blood. In the group II, which received ( P. spinosa ) powder combined with tartrazine, the biochemical and hematological parameters had average values similar to the control group. Conclusions Histopathological assay showed that the application of tartrazine in the group I, II and III produced lesions of the kidneys, spleen and the liver for all rodents. Tartrazine was able to generate histopathological changes, which caused significantly tissue lesions of the liver and significant changes in blood parameters. Blackthorn powder showed a promising protective role for the blood parameters but demonstrated no significant benefits for the organs.

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“…He reported a significant decrease in body weight of treated rats comparing with control. Arefin et al (2017) showed that no mortality and clinical signs among mice treated with Tz but there was growth retardation in mice treated with large dose (400 mg/kg b.wt) but lower dose (200 mg/kg b.wt) didn't affect the body weight gained. On the other hand, Gautum et al (2010) showed that Tz caused significant increase in body weight of rats treated with two doses of Tz (0.2&0.4gm) for 30 days.…”

Section: Discussionmentioning

confidence: 97%

The ameliorative effect of curcumin extract on the morphological and skeletal abnormalities induced by sunset yellow and tartrazine in the developing chick embryo Gallus domesticus

El–Borm

Badawy

El-Nabi

et al. 2020

Heliyon

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Previous studies have suggested that food dyes are responsible for causing number of health problems. The study under consideration aims to show the possible morphological and skeletal malformation induced due to in ovo administration of sunset yellow (SY) and tartrazine (Tz) with or without curcumin (Cur) during organogenesis of developing chick embryo at doses 1.575mg/egg, 0.375mg/egg and 3mg/kg eggs for SY, Tz and Cur comparing with control. The investigation revealed evident reduction in the weight and length of embryos as well as malformations in feather, head, and limbs. Most of the congenital malformations were seen in SY and Tz injected groups such as short beak, excencephaly, kniked tail and pygostyle, curved scapula and retardation in the degree of ossification were the most evident in endoskeleton malformation. In addition, the length of ossified long bones in SY and Tz groups was affected. Co-administration of Cur with SY and Tz ameliorate the reversed effect of SY and Tz on the shape, length, body weight and skeleton of embryos.

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Tartrazine induced changes in physiological and biochemical parameters in Swiss albino mice, Mus musculus

Cited by 14 publications

References 16 publications

Ameliorating Effect of Vitamin E on Liver Damage Caused by Administering Tartrazine in Male Mice

Ameliorating Effect of Vitamin E on Liver Damage Caused by Administering Tartrazine in Male Mice

Protective effect of blackthorn fruits (Prunus spinosa) against tartrazine toxicity development in albino Wistar rats

The ameliorative effect of curcumin extract on the morphological and skeletal abnormalities induced by sunset yellow and tartrazine in the developing chick embryo Gallus domesticus

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