Targeting Transcription Factors for Plant Disease Resistance:Shifting Paradigm

Chattopadhyay, Anirudha; Purohit, Jyotika; Tiwari, Kapil K.; Deshmukh, Rupesh

doi:10.18520/cs/v117/i10/1598-1607

Cited by 14 publications

(11 citation statements)

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“…Transcription factors (TFs) are regulatory proteins that have the ability to alter gene expression reprogramming, plant growth, and plant defense mechanisms. Among the TFs, WRKY is the most responsive in plant defense [50]. WRKY upregulation was observed in CLas-infected susceptible C. sinensis and red tangerine; however, no significant deregulation was observed in tolerant rough lemon [17,33].…”

Section: Discussionmentioning

confidence: 99%

Gene Expression Profile of Mexican Lime (Citrus aurantifolia) Trees in Response to Huanglongbing Disease caused by Candidatus Liberibacter asiaticus

et al. 2020

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Nowadays, Huanglongbing (HLB) disease, associated with Candidatus Liberibacter asiaticus (CLas), seriously affects citriculture worldwide, and no cure is currently available. Transcriptomic analysis of host-pathogen interaction is the first step to understand the molecular landscape of a disease. Previous works have reported the transcriptome profiling in response to HLB in different susceptible citrus species; however, similar studies in tolerant citrus species, including Mexican lime, are limited. In this work, we have obtained an RNA-seq-based differential expression profile of Mexican lime plants challenged against CLas infection, at both asymptomatic and symptomatic stages. Typical HLB-responsive differentially expressed genes (DEGs) are involved in photosynthesis, secondary metabolism, and phytohormone homeostasis. Enrichment of DEGs associated with biotic response showed that genes related to cell wall, secondary metabolism, transcription factors, signaling, and redox reactions could play a role in the tolerance of Mexican lime against CLas infection. Interestingly, despite some concordance observed between transcriptional responses of different tolerant citrus species, a subset of DEGs appeared to be species-specific. Our data highlights the importance of studying the host response during HLB disease using as model tolerant citrus species, in order to design new and opportune diagnostic and management methods.

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Section: Discussionmentioning

confidence: 99%

Gene Expression Profile of Mexican Lime (Citrus aurantifolia) Trees in Response to Huanglongbing Disease caused by Candidatus Liberibacter asiaticus

et al. 2020

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“…Being a transgenic strategy, it is a very cumbersome, costly, and time-consuming process. Further, biosafety and other regulatory issues restrict its widescale field applicability [ 138 ]. Thus, various non-transgenic approaches are prioritized for their future perspective.…”

Section: Remodeling Host Defensementioning

confidence: 99%

Omics Insight on Fusarium Head Blight of Wheat for Translational Research Perspective

Teli

Purohit²,

Rashid

et al. 2020

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: In the scenario of global warming and climate change, an outbreak of new pests and pathogens has become a serious concern owing to the rapid emergence of arms races, their epidemic infection, and the ability to break down host resistance, etc. Fusarium head blight (FHB) is one such evidence that depredates major cereals throughout the world. The symptomatological perplexity and aetiological complexity make this disease very severe, engendering significant losses in the yield. Apart from qualitative and quantitative losses, mycotoxin production solemnly deteriorates the grain quality in addition to life endangerment of humans and animals after consumption of toxified grains above the permissible limit. To minimize this risk, we must be very strategic in designing sustainable management practices constituting cultural, biological, chemical, and host resistance approaches. Even though genetic resistance isthe most effective and environmentally friendly strategy, a huge genetic variation and unstable resistance response limit the holistic deployment of resistance genes in FHB management. Thus, the focus must shift towardsthe editing of susceptible (S) host proteins that are soft targets of newly evolving effector molecules, which ultimately could be exploited to repress the disease development process. Hence, we must understand the pathological, biochemical, and molecular insight of disease development in a nutshell.In the present time,the availability of functional genomics, proteomics, and metabolomics information on host-pathogen interaction in FHB have constructed various networks whichhelped in understanding the events of pathogenesis and coherent host response(s). So now translation of this information for designing of host defense in the form of desirable resistant variety/genotype is the next step. The insightscollected and presented in this review will be aiding understanding the disease and apprise a solution to the multi-faceted problems which are related to FHB resistance in wheat and other cereals to ensure global food safety and food security.

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“…Various genome editing tools like the CRISPR, TALEN, and ZFN enable the programmable modification of microbial genomes [ 114 ]. Other than deletion or gene insertion, these tools can be utilized for the overexpression or repression of certain genes [ 115 ]. The gene regulation by deactivated Cas (dCas) also improves environmental tolerance in the microbial species [ 116 ].…”

Section: Conclusion Challenges and Future Prospectsmentioning

confidence: 99%

Metagenomic Exploration of Plastic Degrading Microbes for Biotechnological Application

Purohit

Chattopadhyay

Teli

2020

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: Since the last few decades, the promiscuous and uncontrolled use of plastics leads to the accumulation of millions of tons of plastic waste in the terrestrial and marine environment and elevated the risk of environmental pollution and climate change. The concern arises more due to the reckless and unscientific disposal of plastics containing high molecular weight polymers, viz., polystyrene, polyamide, polyvinylchloride, polypropylene, polyurethane, and polyethylene, etc. which are very difficult to degrade. Thus, the focus is now paid to search for efficient, eco-friendly, low-cost waste management technology. Of them, degradation of non-degradable synthetic polymer using diverse microbial agents, viz., bacteria, fungi, and other extremophiles become an emerging option. So far, very few microbial agents and their secreted enzymes have been identified and characterized for plastic degradation, but with low efficiency. It might be due to the predominance of uncultured microbial species; consequently remain unexplored from the respective plastic degrading milieu. To overcome this problem, metagenomic analysis of microbial population engaged in the plastic biodegradation is advisable to decipher the microbial community structure and to predict their biodegradation potential in situ. Advancements in sequencing technologies and bioinformatics analysis allow the rapid metagenome screening that helps in the identification of total microbial community and also opens up the scope for mining genes or enzymes (hydrolases, laccase, etc.) engaged in polymer degradation. Further, the extraction of the core microbial population and their adaptation, fitness, and survivability can also be deciphered through comparative metagenomic study. It will help to engineer the microbial community and their metabolic activity to speed up the degradation process.

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Targeting Transcription Factors for Plant Disease Resistance:Shifting Paradigm

Cited by 14 publications

References 0 publications

Gene Expression Profile of Mexican Lime (Citrus aurantifolia) Trees in Response to Huanglongbing Disease caused by Candidatus Liberibacter asiaticus

Gene Expression Profile of Mexican Lime (Citrus aurantifolia) Trees in Response to Huanglongbing Disease caused by Candidatus Liberibacter asiaticus

Omics Insight on Fusarium Head Blight of Wheat for Translational Research Perspective

Metagenomic Exploration of Plastic Degrading Microbes for Biotechnological Application

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