Targeting the Macrophage-Ferroptosis Crosstalk: A Novel Insight into Tumor Immunotherapy

Shi, Yang; Xu, Bo; Hu, Ning; Guo, Zijian; Bao, Wanlin; Shao, Bin; Yang, Wei

doi:10.31083/j.fbl2707203

Cited by 16 publications

(8 citation statements)

References 135 publications

(182 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ferroptosis and ferroptosis-related genes can promote macrophage polarization toward M1 by affecting TAM polarization. Macrophages enhance their pro-inflammatory and antitumor capacities and inhibit tumor cell migration ( Gu, 2021 ; Zhou et al, 2022 ). Some antitumor agents and cytokines can induce ferroptosis to inactivate CAFs and inhibit tumor metastasis, such as disulfiram/copper in nasopharyngeal carcinoma ( Li Y. et al, 2020 ).…”

Section: Ferroptosismentioning

confidence: 99%

Emerging role of ferroptosis-related circular RNA in tumor metastasis

Meng

Cao

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

Tumor metastasis is an important factor that contributes to the poor prognosis of patients with tumors. Therefore, to solve this problem, research on the mechanism of metastasis is essential. Ferroptosis, a new mode of cell death, is characterized by membrane damage due to lipid peroxidation caused by iron overload. Many studies have shown that excessive ferroptosis can affect tumor metastasis and thus inhibit tumor progression. Recently, circular RNA (circRNA), a type of non-coding RNA, has been shown to be associated with the progression of ferroptosis, thus influencing tumor development. However, the specific mechanisms by which circRNAs affect the progression of ferroptosis and their roles in tumor metastasis are not known. In this review, we systematically discuss the role of circRNAs in regulating tumor ferroptosis and their mechanism of action through sponging miRNAS in various tumors, thereby impacting metastasis. This review helps elucidate the relationship and role of ferroptosis-related circRNAs in tumor metastasis and may provide future researchers with new ideas and directions for targeted therapies.

show abstract

Section: Ferroptosismentioning

confidence: 99%

Emerging role of ferroptosis-related circular RNA in tumor metastasis

Meng

Cao

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…In general, macrophages associated with tumors play an important role in both the immune system and tumor microenvironment, and interact with different pathways, including ferroptosis, which are involved in cancer initiation, proliferation, metastasis, in drug resistance, etc. [ 81 , 162 , 163 , 164 , 165 , 166 ]. In particular, during cancer proliferation, adjacent endothelial and other cells are utilized by cancer cells for energy supply and nutrients, including iron, most of which is released during ferritinophagy.…”

Section: Excess Iron Deposition and Toxicity In Non-transfusional Iro...mentioning

confidence: 99%

Iron Load Toxicity in Medicine: From Molecular and Cellular Aspects to Clinical Implications

Kontoghiorghes

2023

IJMS

View full text Add to dashboard Cite

Iron is essential for all organisms and cells. Diseases of iron imbalance affect billions of patients, including those with iron overload and other forms of iron toxicity. Excess iron load is an adverse prognostic factor for all diseases and can cause serious organ damage and fatalities following chronic red blood cell transfusions in patients of many conditions, including hemoglobinopathies, myelodyspasia, and hematopoietic stem cell transplantation. Similar toxicity of excess body iron load but at a slower rate of disease progression is found in idiopathic haemochromatosis patients. Excess iron deposition in different regions of the brain with suspected toxicity has been identified by MRI T2* and similar methods in many neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. Based on its role as the major biological catalyst of free radical reactions and the Fenton reaction, iron has also been implicated in all diseases associated with free radical pathology and tissue damage. Furthermore, the recent discovery of ferroptosis, which is a cell death program based on free radical generation by iron and cell membrane lipid oxidation, sparked thousands of investigations and the association of iron with cardiac, kidney, liver, and many other diseases, including cancer and infections. The toxicity implications of iron in a labile, non-protein bound form and its complexes with dietary molecules such as vitamin C and drugs such as doxorubicin and other xenobiotic molecules in relation to carcinogenesis and other forms of toxicity are also discussed. In each case and form of iron toxicity, the mechanistic insights, diagnostic criteria, and molecular interactions are essential for the design of new and effective therapeutic interventions and of future targeted therapeutic strategies. In particular, this approach has been successful for the treatment of most iron loading conditions and especially for the transition of thalassemia from a fatal to a chronic disease due to new therapeutic protocols resulting in the complete elimination of iron overload and of iron toxicity.

show abstract

“…Macrophages associated with tumors are important components of both the immune system and the tumor microenvironment, and interact with ferroptosis and other pathways involved in cancer initiation, proliferation, metastasis, drug resistance, etc. [158][159][160][161][162].…”

Section: Targeting Of Iron-laden Macrophages and Hyperferritinemia By...mentioning

confidence: 99%

New Iron Metabolic Pathways and Chelation Targeting Strategies Affecting the Treatment of All Types and Stages of Cancer

Kontoghiorghes¹

2022

IJMS

View full text Add to dashboard Cite

There is new and increasing evidence from in vitro, in vivo and clinical studies implicating the pivotal role of iron and associated metabolic pathways in the initiation, progression and development of cancer and in cancer metastasis. New metabolic and toxicity mechanisms and pathways, as well as genomic, transcription and other factors, have been linked to cancer and many are related to iron. Accordingly, a number of new targets for iron chelators have been identified and characterized in new anticancer strategies, in addition to the classical restriction of/reduction in iron supply, the inhibition of transferrin iron delivery, the inhibition of ribonucleotide reductase in DNA synthesis and high antioxidant potential. The new targets include the removal of excess iron from iron-laden macrophages, which affects anticancer activity; the modulation of ferroptosis; ferritin iron removal and the control of hyperferritinemia; the inhibition of hypoxia related to the role of hypoxia-inducible factor (HIF); modulation of the function of new molecular species such as STEAP4 metalloreductase and the metastasis suppressor N-MYC downstream-regulated gene-1 (NDRG1); modulation of the metabolic pathways of oxidative stress damage affecting mitochondrial function, etc. Many of these new, but also previously known associated iron metabolic pathways appear to affect all stages of cancer, as well as metastasis and drug resistance. Iron-chelating drugs and especially deferiprone (L1), has been shown in many recent studies to fulfill the role of multi-target anticancer drug linked to the above and also other iron targets, and has been proposed for phase II trials in cancer patients. In contrast, lipophilic chelators and their iron complexes are proposed for the induction of ferroptosis in some refractory or recurring tumors in drug resistance and metastasis where effective treatments are absent. There is a need to readdress cancer therapy and include therapeutic strategies targeting multifactorial processes, including the application of multi-targeting drugs involving iron chelators and iron–chelator complexes. New therapeutic protocols including drug combinations with L1 and other chelating drugs could increase anticancer activity, decrease drug resistance and metastasis, improve treatments, reduce toxicity and increase overall survival in cancer patients.

show abstract

Targeting the Macrophage-Ferroptosis Crosstalk: A Novel Insight into Tumor Immunotherapy

Cited by 16 publications

References 135 publications

Emerging role of ferroptosis-related circular RNA in tumor metastasis

Emerging role of ferroptosis-related circular RNA in tumor metastasis

Iron Load Toxicity in Medicine: From Molecular and Cellular Aspects to Clinical Implications

New Iron Metabolic Pathways and Chelation Targeting Strategies Affecting the Treatment of All Types and Stages of Cancer

Contact Info

Product

Resources

About