Targeting the gut microbiome: An emerging trend in hematopoietic stem cell transplantation

Ciernikova, Sona; Kasperová, Barbora Judita; Drgoňa, Ľuboš; Smolkova, Bozena; Stevurkova, Viola; Mego, Michal

doi:10.1016/j.blre.2020.100790

Cited by 28 publications

(20 citation statements)

References 104 publications

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“…Treatment-induced changes in bacterial composition highlight the possibilities of microbiota modulation to improve the clinical benefit of anticancer therapies [ 129 ]. Available data suggest that manipulating the microbiota by probiotics and FMT may enhance the treatment efficacy [ 113 ] as well as reduce post-treatment immune-related complications [ 170 ]. Additionally, several studies described the relationship between specific diets and response to anticancer therapy.…”

Section: Microbiota Modulation As An Emerging Tool Towards Improved Response To Anti-cancer Therapiesmentioning

confidence: 99%

The Impact of the Microbiome on Resistance to Cancer Treatment with Chemotherapeutic Agents and Immunotherapy

Sevcikova

Izoldova

Stevurkova

et al. 2022

IJMS

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Understanding the mechanisms of resistance to therapy in human cancer cells has become a multifaceted limiting factor to achieving optimal cures in cancer patients. Besides genetic and epigenetic alterations, enhanced DNA damage repair activity, deregulation of cell death, overexpression of transmembrane transporters, and complex interactions within the tumor microenvironment, other mechanisms of cancer treatment resistance have been recently proposed. In this review, we will summarize the preclinical and clinical studies highlighting the critical role of the microbiome in the efficacy of cancer treatment, concerning mainly chemotherapy and immunotherapy with immune checkpoint inhibitors. In addition to involvement in drug metabolism and immune surveillance, the production of microbiota-derived metabolites might represent the link between gut/intratumoral bacteria and response to anticancer therapies. Importantly, an emerging trend of using microbiota modulation by probiotics and fecal microbiota transplantation (FMT) to overcome cancer treatment resistance will be also discussed.

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Section: Microbiota Modulation As An Emerging Tool Towards Improved Response To Anti-cancer Therapiesmentioning

confidence: 99%

The Impact of the Microbiome on Resistance to Cancer Treatment with Chemotherapeutic Agents and Immunotherapy

Sevcikova

Izoldova

Stevurkova

et al. 2022

IJMS

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“…In comparison to probiotics, prebiotics are viewed as a safer dietary intervention since they involve the consumption of gut bacteria–fermentable dietary fibers such as starches, fructooligosaccharides, and galactooligosaccharides, which alters the community structure of microbiota without elevating the risk of bloodstream infections ( 53 , 60 , 61 ). A combination of glutamine, fiber, and oligosaccharides (GFO) constitutes a commercial Japanese enteral supplementation product considered to be beneficial for restoring chemotherapy-induced GI mucosa damage ( 62 , 63 ).…”

Section: Hematopoietic Stem Cell Transplantationmentioning

confidence: 99%

“…Moreover, the safety of probiotic consumption by HSCT recipients is a matter of contention. Since HSCT recipients experience chemotherapy-and radiotherapy-induced damage to the gut epithelia, they are at an elevated risk of developing sepsis and bacteremia (53)(54)(55)(56)(57). For example, Koyama and colleagues report the cautionary tale of a 54-year-old male acute promyelocytic leukemia patient who consumed probiotic-enriched yogurt and developed septic shock due to the L. rhamnosus GG present in the yogurt (54).…”

Section: Hematopoietic Stem Cell Transplantationmentioning

confidence: 99%

The Impact of Human Microbiotas in Hematopoietic Stem Cell and Organ Transplantation

Sen

Thummer

2022

Front. Immunol.

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The human microbiota heavily influences most vital aspects of human physiology including organ transplantation outcomes and transplant rejection risk. A variety of organ transplantation scenarios such as lung and heart transplantation as well as hematopoietic stem cell transplantation is heavily influenced by the human microbiotas. The human microbiota refers to a rich, diverse, and complex ecosystem of bacteria, fungi, archaea, helminths, protozoans, parasites, and viruses. Research accumulating over the past decade has established the existence of complex cross-species, cross-kingdom interactions between the residents of the various human microbiotas and the human body. Since the gut microbiota is the densest, most popular, and most studied human microbiota, the impact of other human microbiotas such as the oral, lung, urinary, and genital microbiotas is often overshadowed. However, these microbiotas also provide critical and unique insights pertaining to transplantation success, rejection risk, and overall host health, across multiple different transplantation scenarios. Organ transplantation as well as the pre-, peri-, and post-transplant pharmacological regimens patients undergo is known to adversely impact the microbiotas, thereby increasing the risk of adverse patient outcomes. Over the past decade, holistic approaches to post-transplant patient care such as the administration of clinical and dietary interventions aiming at restoring deranged microbiota community structures have been gaining momentum. Examples of these include prebiotic and probiotic administration, fecal microbial transplantation, and bacteriophage-mediated multidrug-resistant bacterial decolonization. This review will discuss these perspectives and explore the role of different human microbiotas in the context of various transplantation scenarios.

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“…The gut microbiome has been found to play a critical role in various cancer treatment modalities. Several gut dysbiosis conditions have been reported in cancer patients receiving hematopoietic stem cell transplantation (HSCT) and in conditioning regimens including chemotherapy, radiotherapy, and immunosuppressive therapy [ 23 ]. Modulation of the microbiota by probiotics, prebiotics, and fecal microbiota transplantation (FMT) in hematologic cancer patients has been reported with increased positive outcome [ 24 ].…”

Section: Gut Microbiome and Cell-based Therapiesmentioning

confidence: 99%

Integrating the Synergy of the Gut Microbiome into Regenerative Medicine: Relevance to Neurological Disorders

Preethy

Ranganathan

Raghavan³

et al. 2022

JAD

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A new paradigm of cell therapy-based approaches as a solution to several diseases caused by damage or loss of cells/tissues leading to organ failure heralded the birth of a new branch in medicine called regenerative medicine (RM), which was further fueled by in vitro cell expansion and tissue engineering (TE) technologies, including the ability to grow embryonic stem cells, induce pluripotent stem cells, and so on. RM addresses organ failure by repair, regeneration, or restoration, rejuvenation using cells, stem cells, or progenitor cells as tools having added cell-derived products also as a tool, and extracellular matrix component–based support, either direct or indirect (e.g., matrix induced autologous chondrocyte implantation) using scaffolds. Now, the main objective of RM is to solve the functional loss of cells that have evolved from cells as tools to cell-derived factors and scaffolds per se as tools. In this context, an important yet indispensable group of cells that constitute the major portion of the human body in terms of the number of cells having several essential roles to play, both directly and indirectly, starting from digestion and the immune system to the growing evidence of influencing neuronal function, aging, and carcinogenesis has been ignored. We would like to focus on these in this review as they should essentially be considered as a tool of RM, especially for neurological disorders for their vital role. What we are indicating is the second genome or the gut microbiome.

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Targeting the gut microbiome: An emerging trend in hematopoietic stem cell transplantation

Cited by 28 publications

References 104 publications

The Impact of the Microbiome on Resistance to Cancer Treatment with Chemotherapeutic Agents and Immunotherapy

The Impact of the Microbiome on Resistance to Cancer Treatment with Chemotherapeutic Agents and Immunotherapy

The Impact of Human Microbiotas in Hematopoietic Stem Cell and Organ Transplantation

Integrating the Synergy of the Gut Microbiome into Regenerative Medicine: Relevance to Neurological Disorders

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