Targeting sialic acid residues on lung cancer cells by inhalable boronic acid-decorated albumin nanocomposites for combined chemo/herbal therapy

Elgohary, Mayada M.; Helmy, Maged W.; Abdelfattah, Elsayeda-Zeinab A.; Ragab, Doaa; Mortada, Sana Mohamed; Fang, Jia‐You; Elzoghby, Ahmed O.

doi:10.1016/j.jconrel.2018.07.014

Cited by 58 publications

(24 citation statements)

References 56 publications

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“…After the formation of the FL and NB‐labeled core particles, a shell consisting of NIPMAM, BIS, and 3‐acrylamidophenylboronic acid (APBA) was formed (Scheme 1) which was evaluated by 1 H NMR spectroscopy (Figure S2). It is know that APBA is enhancing cellular uptake in cancer cells, due to its ability to bind to the overexpressed sialic acid on the surface of cancer cells [28–30] . The difference in extracellular and intracellular reactivity as well as the intrinsic stability difference between esters and amides facilitate control over the release of incorporated molecules from the nanogel at the desired location (intracellular).…”

Section: Methodsmentioning

confidence: 99%

“…It is know that APBA is enhancing cellular uptake in cancer cells, due to its ability to bind to the overexpressed sialic acid on the surfaceo fc ancer cells. [28][29][30] The differencei n extracellular and intracellular reactivity as well as the intrinsic stabilityd ifference between esters and amides facilitatecontrol over the release of incorporated molecules from the nanogel at the desired location (intracellular). After uptake of nanogels by cells via endocytosis, it was envisioned that there would be af ast releaseo fe ster-conjugated structures from the nanogel due to the presence of esterases in endosomes,w hereas the amide-conjugated structures will remaina ssociated with the nanogel as illustrated in Scheme 1a nd Figure S1.…”

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confidence: 99%

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Nanogels with Selective Intracellular Reactivity for Intracellular Tracking and Delivery

Mergel

Ribovski

et al. 2020

Chemistry A European J

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Am ultimodal approach for hydrogel-based nanoparticles was developed to selectively allow molecular conjugated species to either be released inside the cell or remain connected to the polymer network. Using the intrinsic differencei nr eactivity between esters and amides, nanogels with an amide-conjugated dye could be trackedintracellularlyl ocalizingnext to the nucleus, while ester-conjugation allowed for liberation of the molecular speciesf rom the hydrogeln etwork inside the cell, enabling delivery throughout the cytoplasm. The releasewas ar esult of particlee xposure to the intracellular environment. The conjugationa pproach and polymer network buildingr ely on the same chemistry and provide ad iverse range of possibilities to be used in nanomedicine and theranostic approaches.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Nanogels with Selective Intracellular Reactivity for Intracellular Tracking and Delivery

Mergel

Ribovski

et al. 2020

Chemistry A European J

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“…Nanocomposites composed of HAS, aminophenylboronic acid (APBA) and phospholipid co‐loaded with etoposide and berberine (BER) for inhaled administration of lung cancer (Reprinted with permission from Elgohary et al (2018). Copyright 2018 Elsevier B.V.)…”

Section: Deliver Drugs For Lung Cancer By Nanomaterialsmentioning

confidence: 99%

“…Mayada et al designed etoposide (ETP) liposomes co‐loaded with the herbal drug, berberine (BER) into HSA NPs for synergistic therapy against lung cancer. The HSA NPs conjugated by aminophenylboronic acid (APBA) could bind to cancer cell with overexpression of sialic acid residues and in vivo investigations revealed the antitumor effect in chemically‐induced lung cancer mouse models (Figure 2) (Elgohary et al, 2018).…”

Section: Deliver Drugs For Lung Cancer By Nanomaterialsmentioning

confidence: 99%

Nanomedicine in lung cancer: Current states of overcoming drug resistance and improving cancer immunotherapy

Wang

Hao

Liu

et al. 2020

WIREs Nanomed Nanobiotechnol

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Lung cancer is considered to cause the most cancer‐related deaths worldwide. Due to the deficiency in early‐stage diagnostics and local invasion or distant metastasis, the first line of treatment for most patients unsuitable for surgery is chemotherapy, targeted therapy or immunotherapy. Nanocarriers with the function of improving drug solubility, in vivo stability, drug distribution in the body, and sustained and targeted delivery, can effectively improve the effect of drug treatment and reduce toxic and side effects, and have been used in clinical treatment for lung cancer and many types of cancers. Here, we review nanoparticle (NP) formulation for lung cancer treatment including liposomes, polymers, and inorganic NPs via systemic and inhaled administration, and highlight the works of overcoming drug resistance and improving cancer immunotherapy. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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“…[264][265][266][267][268][269][270] As natural endogenous ligands, bile acids have good biocompatibility and are ideal routes for targeting hepatocellular cancer. 271 In addition, sialic acid, 272 International Journal of Nanomedicine downloaded from https://www.dovepress.com/ by 44.224.250.200 on 02-Oct-2020 For personal use only.…”

Section: Low-density Lipoprotein-modified Nanocarriersmentioning

confidence: 99%

<p>Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment</p>

Fan

et al. 2019

IJN

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Cancer is a major public health problem, and is now the world's leading cause of death. Traditional Chinese medicine (TCM)-combination therapy is a new treatment approach and a vital therapeutic strategy for cancer, as it exhibits promising antitumor potential. Nanotargeted drug-delivery systems have remarkable advantages and allow the development of TCM-combination therapies by systematically controlling drug release and delivering drugs to solid tumors. In this review, the anticancer activity of TCM compounds is introduced. The combined use of TCM for antitumor treatment is analyzed and summarized. These combination therapies, using a single nanocarrier system, namely codelivery, are analyzed, issues that require attention are determined, and future perspectives are identified. We carried out a systematic review of .280 studies published in PubMed since 1985 (no patents involved), in order to provide a few basic considerations in terms of the design principles and management of targeted nanotechnology-based TCM-combination therapies.

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Targeting sialic acid residues on lung cancer cells by inhalable boronic acid-decorated albumin nanocomposites for combined chemo/herbal therapy

Cited by 58 publications

References 56 publications

Nanogels with Selective Intracellular Reactivity for Intracellular Tracking and Delivery

Nanogels with Selective Intracellular Reactivity for Intracellular Tracking and Delivery

Nanomedicine in lung cancer: Current states of overcoming drug resistance and improving cancer immunotherapy

<p>Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment</p>

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