Targeting ROS overgeneration by N-benzyl-2-nitro-1-imidazole-acetamide as a potential therapeutic reposition approach for cancer therapy

Zeferino, Rodrigo C.; Mota, Nádia S.R.S.; Grinevicius, Valdelúcia M.A.S.; Filipe, Karina B; Sulis, Paola Miranda; Silva, Fátima R M B; Filho, Danilo Wilhelm; Pich, Claus Tröger; Pedrosa, Rozangela Curi

doi:10.1007/s10637-019-00820-5

Cited by 5 publications

(4 citation statements)

References 49 publications

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“…We thereafter verified that GPX1 was the downstream target binding GABPA by miRDB starbase. GPXs (glutathione peroxides) are vital antioxidant enzymes in the body, which are responsible for eliminating ROS [18] . GPX1 is the most common antioxidant enzyme in the GPX family.…”

Section: Discussionmentioning

confidence: 99%

GABPA protects against gastric cancer deterioration via negatively regulating GPX1

Yin¹,

Dong²,

X³

et al. 2022

J Med Biochemistry

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Background: To explore the anti-cancer role of GABPA in the progression of gastric cancer (GC), and the underlying mechanism. Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was conducted to detect the expression pattern of GABPA in 45 pairs of GC and non-tumoral tissues. The relationship between GABPA expression and clinic pathological indicators of GC patients was analyzed. In AGS and SGC-7901 cells overexpressing GABPA, their migratory ability was determined by trans well and wound healing assay. The interaction between GABPA and its downstream target GPX1 was explored by dual-luciferase reporter assay, and their synergistical regulation on GC cell migration was finally elucidated. Results: GABPA was downregulated in GC tissues in comparison to normal ones. Low level of GABPA predicted high incidences of lymphatic and distant metastasis in GC. Overexpression of GABPA blocked AGS and SGC-7901 cells to migrate. GABPA could target GPX1 via the predicted binding site. GPX1 was upregulated in clinical samples of GC, and negatively correlated to GABPA level. The anticancer effect of GABPA on GC relied on the involvement of GPX1. Conclusions: GABPA is downregulated in GC samples, which can be utilized to predict GC metastasis. Serving as a tumor suppressor, GABPA blocks GC cells to migrate by targeting GPX1.

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Section: Discussionmentioning

confidence: 99%

GABPA protects against gastric cancer deterioration via negatively regulating GPX1

Yin¹,

Dong²,

X³

et al. 2022

J Med Biochemistry

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“…ROS plays an important role in the control of apoptosis and proliferation, in which a moderate increase in ROS level is conducive to cell proliferation, while excessive ROS induces apoptosis, by a mechanism that may be related to intracellular Ca2+ inflow, and CYP450 can increase oxidative stress and induce cytotoxicity together with ROS, 53 and ROS is involved in the generation of blood vessels. 54,55 It is different from other factors previously introduced: both diabetes and tumor-related microenvironment are highly expressed, and the mechanism of this phenomenon is related to the following two aspects: ① Microenvironment characteristics: hypoxia can promote high ROS in the tumor microenvironment; 51 high glucose induces and activates nicotinamide adenine dinucleotide phosphate (NADPH) oxidases to produce ROS.…”

Section: Rosmentioning

confidence: 99%

“…54 In terms of tumor treatment, decylubiquinone and Benznidazole have anti-tumor effects by inducing ROS overproduction, while Brain angiogenesis inhibitor 1 (BAI1) has been shown to inhibit ROS production and is expected to achieve therapeutic effects. 53,54 Therefore, in general, both treatments, raising basic ROS levels to toxic levels and reducing ROS levels, are effective targets for tumor therapy. In the treatment of diabetes, Epicatechin has been proven to activate eNOS and has achieved a certain efficacy.…”

Section: Rosmentioning

confidence: 99%

Differences of Angiogenesis Factors in Tumor and Diabetes Mellitus

Tan¹,

Zang²,

Wang³

et al. 2021

DMSO

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Angiogenesis, as a process occurring under the regulation of a variety of factors, is one of the important ways of vascular development. It coexists in a variety of pathological and physiological processes. Now a large number of studies have proved that tumor growth, metastasis, and various vascular complications of diabetes are closely related to angiogenesis, and an increasing number of studies have shown that there are many common factors between the two. But angiogenesis is the opposite of the two: it is enhanced in tumors and suppressed in diabetes. Therefore, this review discusses the causes of the phenomenon from the expression of various factors affecting angiogenesis in these two diseases and their effects on angiogenesis in the relevant microenvironment, as well as the application status of these factors or cells as therapeutic targets in the treatment of these two diseases.

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“…Topalovski et al ( 70 ) found that fibulin-5 can promote ROS production in vascular endothelial cells by acting on the fibronectin receptor β1 to exert its anti-angiogenic effects in pancreatic cancer cells. In addition, N-benzyl-2-nitro-1-imidazole-acetamide, a therapeutic agent for Chagas disease, has been found to exert anti-tumor effects in Ehrlich tumor cells by increasing ROS levels and inhibiting angiogenesis ( 71 ). Synthesis of redox regulators using silver nanoframe technology has been shown to induce excessive ROS generation and enhance cytotoxicity in the vascular endothelium ( 72 ).…”

Section: Ros and Tmementioning

confidence: 99%

Role of reactive oxygen species in tumors based on the ‘seed and soil’ theory: A complex interaction (Review)

Liang

et al. 2021

Oncol Rep

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Tumor microenvironment (TME) can serve as the 'soil' for the growth and survival of tumor cells and function synergically with tumor cells to mediate tumor progression and therapeutic resistance. Reactive oxygen species (ROS) is somewhat of a double-edged sword for tumors. Accumulating evidence has reported that regulating ROS levels can serve an anti-tumor role in the TME, including the promotion of cancer cell apoptosis, inhibition of angiogenesis, preventing immune escape, manipulating tumor metabolic reorganization and improving drug resistance. In the present review, the potential role of ROS in anti-tumor therapy was summarized, including the possibility of directly or indirectly targeting the TME. Contents 1. Introduction 2. ROS and TME 3. ROS and tumor drug resistance 4. Conclusions

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Targeting ROS overgeneration by N-benzyl-2-nitro-1-imidazole-acetamide as a potential therapeutic reposition approach for cancer therapy

Cited by 5 publications

References 49 publications

GABPA protects against gastric cancer deterioration via negatively regulating GPX1

GABPA protects against gastric cancer deterioration via negatively regulating GPX1

Differences of Angiogenesis Factors in Tumor and Diabetes Mellitus

Role of reactive oxygen species in tumors based on the ‘seed and soil’ theory: A complex interaction (Review)

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