Role of reactive oxygen species in tumors based on the ‘seed and soil’ theory: A complex interaction (Review)

Abstract

Tumor microenvironment (TME) can serve as the 'soil' for the growth and survival of tumor cells and function synergically with tumor cells to mediate tumor progression and therapeutic resistance. Reactive oxygen species (ROS) is somewhat of a double-edged sword for tumors. Accumulating evidence has reported that regulating ROS levels can serve an anti-tumor role in the TME, including the promotion of cancer cell apoptosis, inhibition of angiogenesis, preventing immune escape, manipulating tumor metabolic reorganization and improving drug resistance. In the present review, the potential role of ROS in anti-tumor therapy was summarized, including the possibility of directly or indirectly targeting the TME. Contents 1. Introduction 2. ROS and TME 3. ROS and tumor drug resistance 4. Conclusions

Piper nigrum extract retards tumor growth by reducing tumor-promoted cytokines/chemokines and modulating immune cells in blood circulation

“…ROS maintenance to a certain level is necessary and required for cellular proliferation and survival [38]. On the other hand, the rise in ROS can promote cancer cell death, inhibit cancer cell angiogenesis, and prevents immune escape in TME [39]. In this study, PFPE increased MDA levels compared to control and vehicle groups.…”

RNA 5-methylcytosine status is associated with DNMT2/TRDMT1 nuclear localization in osteosarcoma cell lines

“…A moderate increase in ROS levels has been shown to promote pro-tumorigenic signaling, enhance tumor development and progression, drive DNA damage and genome instability, and modulate drug resistance [34] , [37] . However, ROS are also capable of triggering programmed cell death by activating signaling pathways and modulation of oxidative stress is considered as an anticancer strategy [34] , [37] , [38] , [39] . As different susceptibility to cell death was documented in three OS cell lines ( Fig.…”

Drug-induced oxidative stress in cancer treatments: Angel or devil?

“…Consequently, manipulating intracellular redox status of cancer cells seems to be an attractive and promising approach for cancer therapy. However, studies have shown that some pro-oxidant therapies also promote ROS-induced drug resistance [ 181 , 182 ]. Possible causes may include lipid peroxidation during OS induced by chemotherapy drugs.…”