Targeting of Potassium Channels in Cardiac Arrhythmias

Burg, Shira; Attali, Bernard

doi:10.1016/j.tips.2021.03.005

Cited by 30 publications

(28 citation statements)

References 129 publications

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“…In addition, potassium channels are key regulators in maintaining action potential prolongation and cardiac rhythm ( 37 ). Abnormal potassium channel expression results in aberrant cardiac currents and even sudden cardiac death ( 38 ).…”

Section: Roles Of Lncrnas In the Pathogenesis Of Hfmentioning

confidence: 99%

Long non-coding RNAs in the pathogenesis of heart failure: A literature review

Fan

Zhang²,

Zheng

et al. 2022

Front. Cardiovasc. Med.

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Heart failure (HF) is a common cardiovascular disorder and a major cause of mortality and morbidity in older people. The mechanisms underlying HF are still not fully understood, restricting novel therapeutic target discovery and drug development. Besides, few drugs have been shown to improve the survival of HF patients. Increasing evidence suggests that long non-coding RNAs (lncRNAs) serve as a critical regulator of cardiac physiological and pathological processes, regarded as a new target of treatment for HF. lncRNAs are versatile players in the pathogenesis of HF. They can interact with chromatin, protein, RNA, or DNA, thereby modulating chromatin accessibility, gene expressions, and signaling transduction. In this review, we summarized the current knowledge on how lncRNAs involve in HF and categorized them into four aspects based on their biological functions, namely, cardiomyocyte contractility, cardiac hypertrophy, cardiac apoptosis, and myocardial fibrosis. Along with the extensive laboratory data, RNA-based therapeutics achieved great advances in recent years. These indicate that targeting lncRNAs in the treatment of HF may provide new strategies and address the unmet clinical needs.

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Section: Roles Of Lncrnas In the Pathogenesis Of Hfmentioning

confidence: 99%

Long non-coding RNAs in the pathogenesis of heart failure: A literature review

Fan

Zhang²,

Zheng

et al. 2022

Front. Cardiovasc. Med.

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“…Several studies have documented the pathophysiological role of the K + channel in cardiac arrhythmia, hypertension, epilepsy, Alzheimer’s disease, type 2 diabetes mellitus, and age-related hearing loss ( Tian et al, 2014 ; Burg and Attali, 2021 ; Singh et al, 2021 ). Figure 1 illustrates some disorders associated with K + channel dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Interaction of Medicinal Plants and Their Active Constituents With Potassium Ion Channels: A Systematic Review

Rajabian

Babaei

et al. 2022

Front. Pharmacol.

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Potassium ion (K+) channels are pore-forming transmembrane proteins that control the transport of K+ ions. Medicinal plants are widely used as complementary therapies for several disorders. Studies have shown that the modulation of K+ channels is most likely involved in various pharmacological effects of medicinal plants. This review aimed to evaluate the modulatory effects of medicinal plants and their active constituents on K+ channels under pathological conditions. This systematic review was prepared according to the Preferred Reporting Items for the Systematic Reviews and Meta-analyses (PRISMA) 2020 guideline. Four databases, including PubMed, Web of Science, embase, and Scopus, were searched. We identified 687 studies from these databases, from which we selected 13 in vivo studies for the review by using the Population, Intervention, Comparison, Outcomes, Study (PICOS) tool. The results of the 13 selected studies showed a modulatory effect of medicinal plants or their active constituents on ATP-sensitive potassium channels (KATP), and small (SKCa) and large (BKCa) conductance calcium-activated K+ channels in several pathological conditions such as nociception, brain ischemia, seizure, diabetes, gastric ulcer, myocardial ischemia-reperfusion, and hypertension via possible involvement of the nitric oxide/cyclic GMP pathway and protein kinase. K+ channels should be considered as significant therapeutic milestones in the treatment of several diseases. We believe that understanding the mechanism behind the interaction of medicinal plants with K+ channels can facilitate drug development for the treatment of various K+ channel-related disorders.

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“…Ectopic atrial foci are thought caused by an enhanced automaticity, delayed afterdepolarizations (DADs) and/or early afterdepolarizations (EADs) [10]. There is no doubt that the autonomic nervous system (ANS) also cooperates in the triggers, substrate and perpetuators of AF [11].…”

mentioning

confidence: 99%

Unraveling the Role of K2P Channels in Atrial Fibrillation

Mondéjar-Parreño¹

2022

Front. Biosci. (Schol Ed)

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Atrial fibrillation (AF) is a condition in which the electrical signals in the upper heart chambers (atria) are rapid and disorganized, producing an irregular and chaotical heartbeat. The sinus rhythm should be between 60 to 100 bpm at rest, while the heart rhythm in AF patients may be over 140 bpm. Either structural and electro-mechanical remodeling of the atrial tissue underlies the perpetuation and evolution of AF from the paroxysmal to persistent form. Unravelling the different pathological pathways involved in AF that lead to arrhythmogenesis and atrial remodeling is needed to discovery new and effective therapeutic approaches. A variety of drugs are available to convert and maintain the AF patient in a normal sinus rhythm; however, these strategies have limited chances of success or fail with the progression of AF to more persistent/permanent forms. Consequently, it is necessary to find new therapeutic targets for the relief of persistent or chronic AF forms, as well as the development of new and more effective pharmacological tools. The atrial specific two-pore domain K + channels (K2P) constitute the background K + current on atrial cardiomyocytes and modulate cell excitability emerging as novel targets in this disease and avoiding ventricle side effects. Moreover, several antiarrhythmic drugs used in AF treatment exert their mechanism of action in part by modulation of K2P channels. Thus far, TWIK-1, TREK-1, TASK-1, TASK-2 and TASK-3 channel have been identified as responsible for background currents IK2P current in atrial cells; however, it is not excluded that other K2PX subunits or subfamilies have physiological roles in atria. To date, a great diversity openers, activators and blockers of K2P channel have been identified, particularly those targeting TASK and TREK channels. Several studies have demonstrated that the expression of TWIK-1, TREK-1, TASK-1, TASK-2 and TASK-3 are dysregulated in AF and their pharmacology rescue could suppose a novel therapy in AF. The main objective is to examine the regulation of K2P channels and the current K2P channels pharmacological modulators for AF treatment.

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Targeting of Potassium Channels in Cardiac Arrhythmias

Cited by 30 publications

References 129 publications

Long non-coding RNAs in the pathogenesis of heart failure: A literature review

Long non-coding RNAs in the pathogenesis of heart failure: A literature review

Interaction of Medicinal Plants and Their Active Constituents With Potassium Ion Channels: A Systematic Review

Unraveling the Role of K2P Channels in Atrial Fibrillation

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