Targeting nanocomposites with anti-oxidative/inflammatory/angiogenic activities for synergistically alleviating macular degeneration

Luo, Lan; Jian, Hong-Jyuan; Harroun, Scott G.; Lai, Jui‐Yang; Unnikrishnan, Binesh; Huang, Chih‐Ching

doi:10.1016/j.apmt.2021.101156

Cited by 15 publications

(8 citation statements)

References 86 publications

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“…Very convincing evidence and clinically relevant data now support that nanomaterials show great promise as potential tools in therapeutic approaches for ocular diseases. − Recently, dopamine-derived synthetic melanin-like nanoparticles (MNPs) have been suggested as a more potent and safer nano-antioxidant in biomedical applications, with high biological relevance to natural melanin. − We investigate the trafficking pathway and the final destination of PEGylated-synthetic MNPs in biological systems and determine whether MNPs can be an alternative for natural melanin in RPE cells in vitro and in vivo . Our results provide strong evidence for their roles in attenuating pathological damages in AMD models.…”

Section: Introductionmentioning

confidence: 99%

Melanin-like Nanoparticles as an Alternative to Natural Melanin in Retinal Pigment Epithelium Cells and Their Therapeutic Effects against Age-Related Macular Degeneration

et al. 2022

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Melanin is a natural pigment that is widely distributed in many parts of the human body, such as the skin and retinal pigment epithelium (RPE) in eyes. In contrast to skin melanin, which is being constantly synthesized by the epidermal melanocytes, melanin in the RPE does not regenerate. Melanin is known to function as a potential radical scavenger and photoprotective agent. However, the protective effects of melanin against oxidative stress decline with increasing age. This phenomenon has been correlated with the pathogenesis of age-related macular degeneration (AMD). To increase the potential antioxidant and photoprotective characteristics of melanin, we designed a therapeutic strategy for replenishment of melanin using PEGylated synthetic melanin-like nanoparticles (MNPs) in the RPE for the treatment of AMD. We performed experiments using AMD-like cellular and mouse models and demonstrated that MNPs are biocompatible and selectively target reactive oxygen species (ROS) with powerful antioxidant properties. MNPs can traffic and accumulate in the RPE and are exclusively located in cytosol, but not the nucleus and mitochondria of the cells, for at least 3 months after a single-dose intravitreal injection. Our findings demonstrate that MNPs are able to substitute for natural melanin in the RPE and suggest the potential efficacy of MNPs as a natural radical scavenger against oxidative stress in ROS-related diseases, such as AMD.

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Section: Introductionmentioning

confidence: 99%

Melanin-like Nanoparticles as an Alternative to Natural Melanin in Retinal Pigment Epithelium Cells and Their Therapeutic Effects against Age-Related Macular Degeneration

et al. 2022

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“…Protective Effect against NaIO 3 -Induced ROS Production. Oxidative stress is one of the many factors in the pathogenesis of AMD, 48 and NaIO 3 -induced ARPE-19 cell damage through oxidative stress can be used to simulate the pathogenesis of AMD. 49,50 ARPE-19 cells treated with NaIO 3 and lutein-loaded nanoparticles simultaneously were then stained with DCFH-DA to determine the antioxidative impact on ROS generation.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Preparation of Lutein Nanoparticles by Glycosylation of Saccharides and Casein for Protecting Retinal Pigment Epithelial Cells

Liu,

Zhang,

Liu

et al. 2024

J. Agric. Food Chem.

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Age-related macular degeneration (AMD), a leading cause of visual impairment in the aging population, lacks effective treatment options due to a limited understanding of its pathogenesis. Lutein, with its strong antioxidant properties and ability to mitigate AMD by absorbing ultraviolet (UV) rays, faces challenges related to its stability and bioavailability in functional foods. In this study, we aimed to develop delivery systems using protein−saccharide conjugates to enhance lutein delivery and protect adult retinal pigment epithelial (ARPE-19) cells against sodium iodate (NaIO 3 )-induced damage. Various saccharides, including mannose, galactose, lactose, maltose, dextran, and maltodextrin, were conjugated to casein via the Maillard reaction for lutein delivery. The resulting lutein-loaded nanoparticles exhibited small size and spherical characteristics and demonstrated improved thermal stability and antioxidant capacity compared to free lutein. Notably, these nanoparticles were found to be nontoxic, as evidenced by reduced levels of cellular reactive oxygen species production (167.50

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“…including inflammatory, oxidative stress and lipid metabolism [16] . Intravitreal injection of anti-VEGF drugs is currently the main treatment for AMD [17] , but it was known that frequent intravitreal injections carried risks such as bleeding, infection, retinal detachment [18] . Many studies have found that apoptosis of RPE cells caused by oxidative stress is one of the main causes of AMD.…”

Section: Fa and Amdmentioning

confidence: 99%

The Potential Values of Ferulic Acid in Ophthalmic Diseases

Wang

Yao

et al. 2023

Preprint

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Ferulic acid, as a common polyphenol in Chinese herbal medicine, is widely found in rice, vegetables and fruits. It has important antioxidant effects and has an effect in a variety of diseases. However, the mechanism of its antioxidant function is very complex, including regulation of pro-inflammatory factors, scavenging free radicals and inhibition of lipid peroxidation. The signaling pathway of ferulic acid in exerting its antioxidant effect has not been fully found. Recent studies have found that ferulic acid has a very important potential application value in the treatment of ophthalmic diseases, including glaucoma, cataract, age-related macular degeneration, etc. This paper reviews the effects and referring signaling pathway of ferulic acid in eye diseases and conclude the potential signal pathways of ferulic acid in order to provide new ideas for traditional Chinese medicine in the treatment of eye diseases.

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Targeting nanocomposites with anti-oxidative/inflammatory/angiogenic activities for synergistically alleviating macular degeneration

Cited by 15 publications

References 86 publications

Melanin-like Nanoparticles as an Alternative to Natural Melanin in Retinal Pigment Epithelium Cells and Their Therapeutic Effects against Age-Related Macular Degeneration

Melanin-like Nanoparticles as an Alternative to Natural Melanin in Retinal Pigment Epithelium Cells and Their Therapeutic Effects against Age-Related Macular Degeneration

Preparation of Lutein Nanoparticles by Glycosylation of Saccharides and Casein for Protecting Retinal Pigment Epithelial Cells

The Potential Values of Ferulic Acid in Ophthalmic Diseases

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