Targeting Mitogen-Activated Protein Kinases by Natural Products: A Novel Therapeutic Approach for Inflammatory Bowel Diseases

Abstract

: An increase in the prevalence of IBD as a multifactorial intestinal chronic inflammation as well as the absence of a certain cure, has created an innovative era in the management of IBD by molecule/pathway-based anti-inflammatory approaches. : There are credible documentations that demonstrate MAPK acts as IBD regulator. Upon the activation of MAPK signalling pathway, the transcription and expression of various encoding inflammatory molecules implicated in IBD are altered, thereby exacerbating the inflammation development. The current pharmacological management of IBD, including drug and biological therapies are expensive, possess temporary relief and some adverse effects. In this context, a variety of dietary fruits or medicinal herbs have received worldwide attention versus the development of IBD. : In fact, natural ingredients such as Flavaglines, Fisetin, Myricitrin, Cardamonin, Curcumin, Octacosanol and Mangiferin possess protective and therapeutic effects against IBD via modulation of different segments of MAPK signaling pathway. This paper calls attention to the role of MAPK signaling triggered by natural products in the prevention and treatment of IBD.

Coral-Derived Endophytic Fungal Product, Butyrolactone-I, Alleviates Lps Induced Intestinal Epithelial Cell Inflammatory Response Through TLR4/NF-κB and MAPK Signaling Pathways: An in vitro and in vivo Studies

“…IBD and other autoimmune diseases have also been linked to the NF-κB protein (7). MAPKs are composed of various serine and threonine kinases that induce inflammation (8). Other evidence suggests that inhibiting the NF-κB and MAPK signaling pathways is vital in IBD treatment (9).…”

Using Network Pharmacology and Molecular Docking Technology to Explore the Mechanism of Modified Pulsatilla Decoction in the Treatment of Ulcerative Colitis

“…After inflammatory factors activate the MAPK signaling pathway, the transcription and expression of inflammatory genes related to inflammatory bowel disease (IBD) are changed, which intensifies the development of inflammation. 44 In IBD model mice, the expression of MAPK1/3 increased significantly. However, its expression decreased after drug treatment.…”

Based on Network Pharmacology to Explore the Potential Bioactive Compounds and Mechanisms of Zuojin Pill for the Treatment of Ulcerative Colitis

“…Finally, based on the two aspects of network construction and central network evaluation, 26 key targets of the ZJP potential target network were selected which were significantly enriched in three UCrelated signaling pathways, including the PI3K-Akt signaling pathway, MAPK signaling pathway, and toll-like receptor signaling pathway. Studies have shown that the PI3K-Akt signaling pathway could regulate the inflammation and oxidative stress of UC [12,13]; the MAPK pathway played a key role in regulating the development of UC inflammation Evidence-Based Complementary and Alternative Medicine [14]; the toll-like receptor signaling pathway played an important role in the immune system and participated in the inflammatory process of UC [15]. However, the key target of this study enriched in the toll-like receptor signaling pathway was focused on the downstream MAPK pathway crosstalk.…”