Targeting inflammasomes: A possible therapeutic approach for periodontal disease (Review)

Rana, Anju; Kaur, Arundeep; Faraz, Farrukh; Tandon, Shruti

doi:10.3892/wasj.2021.121

Cited by 4 publications

(6 citation statements)

References 50 publications

(66 reference statements)

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“…Metformin, an oral antidiabetic drug, exhibits anti-inflammatory effects by reducing the activity of inflammasomes containing NLRP3, suggesting that anti-inflammatory drugs may be useful in the prevention and treatment of periodontal disease [ 42 ]. In addition, it has been reported that many drugs, such as allopurinol and nicotinamide riboside, inhibit intracellular signaling, and pralnacasan and emricasan inhibit caspase-1, and that many drugs act on various stages of the inflammatory reaction to exhibit anti-inflammatory responses [ 43 ]. However, it is not easy to introduce these anti-inflammatory drugs in rural Africa and distribute them in a short period.…”

Section: Discussionmentioning

confidence: 99%

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Oral cleaning habits and the copy number of periodontal bacteria in pregnant women and its correlation with birth outcomes: an epidemiological study in Mibilizi, Rwanda

et al. 2022

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Background Since 1996, many studies have reported that periodontal disease during pregnancy may be a risk factor for preterm birth and low birth weight; however, in Africa, periodontal disease is considered a non-high-priority disease. In addition, there are few dental facilities in rural Rwanda; thus, the oral condition of pregnant women has not been investigated. The objective of this study was to assess the tooth brushing habits of pregnant women in rural Rwanda and evaluate whether periodontal bacteria in the oral cavity of pregnant women are related to birth outcomes or oral cleaning habits. Methods A questionnaire survey and saliva collection were conducted for pregnant women in the catchment area population of Mibilizi Hospital located in the western part of Rwanda. Real-time PCR was performed to quantitatively detect total bacteria and 4 species of periodontal bacteria. The relationship of the copy number of each bacterium and birth outcomes or oral cleaning habits was statistically analyzed. Results Among the participants, high copy numbers of total bacteria, Tannerella forsythia, and Treponema denticola were correlated with lower birth weight (p = 0.0032, 0.0212, 0.0288, respectively). The sex ratio at birth was higher in women who had high copy numbers of Porphyromonas gingivalis and T. denticola during pregnancy (p = 0.0268, 0.0043). Furthermore, regarding the correlation between oral cleaning habits and the amount of bacteria, the more frequently teeth were brushed, the lower the level of P. gingivalis (p = 0.0061); the more frequently the brush was replaced, the lower the levels of P. gingivalis and T. forsythia (p = 0.0153, 0.0029). Conclusions This study suggested that improving tooth brushing habits may reduce the risk of periodontal disease among pregnant women in rural Rwanda. It also indicated that the amount of bacteria is associated with various birth outcomes according to the bacterial species. Both access to dental clinics and the oral cleaning habits of pregnant women should be important considerations in efforts to alleviate reproductive-related outcomes in rural Africa.

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Section: Discussionmentioning

confidence: 99%

“…43.8%) and 86 females (56.2%). Three pairs of twins (3/156: 1.9%) were born, but they were not included in this table GA gestational age, BW birth weight a One participant who delivered a male newborn did not answer the questionnaire…”

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confidence: 97%

Oral cleaning habits and the copy number of periodontal bacteria in pregnant women and its correlation with birth outcomes: an epidemiological study in Mibilizi, Rwanda

et al. 2022

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“…As a homeostatic checkpoint, inflammasomes control the degree of inflammation in both health and disease. Having a better understanding of the various methods that can be used to control an excessive inflammatory response at the cellular and molecular level may help to develop treatments and preventative measures that are more successful in treating periodontal disease and the systemic diseases that are linked to it (21)(22)(23).…”

Section: The Role Of Inflammasomes In the Pathogenesis Of Periodontitismentioning

confidence: 99%

Possible Role of Inflammasomes in the Pathogenesis of Periodontal Diseases

Hashim¹,

Babiker²,

Mohammed³

et al. 2023

Preprint

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Dr. Jurg Tschopp created the word "inflammasome" in 2002. Inflammasome activation and its function in disease processes have been the subject of significant investigation over the last 15 years. Four important inflammasomes have been identified: NLRP1, NLRP3, NLRC4, and AIM2. When these inflammasomes are activated, they process and secrete inflammatory cytokines such as IL-1b and IL-18, as well as cause pyroptosis, an inflammatory form of cell death. In this review, we will look at how these inflammasomes have been connected to Periodontitis pathogenesis.

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“…Inflammasomes play a role in the control of inflammation in both healthy and diseased individuals. A better understanding of the various methods that can be employed to control excessive inflammatory responses at the cellular and molecular levels may help develop treatments and preventative measures that are more successful in treating periodontal and systemic diseases linked to it (21)(22)(23).…”

Section: Inflammasomes Play An Essential Role In the E229mentioning

confidence: 99%

The role of inflammasomes in periodontal disease and pathogenesis

2023

JPTCP

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Inflammasomes are complex cellular structures that play crucial roles in the pathogenesis of periodontal disease. Inflammasomes are proteins that sense microbial pathogens in the host and trigger an inflammatory response. This response is vital for combating infection but can also damage tissue if inflammation is not controlled. Several studies have reviewed the role of inflammasomes in periodontal disease. In periodontal disease, inflammasome activation has been linked to the release of pro-inflammatory cytokines, which can lead to tissue destruction and periodontal damage. The term "inflammasome" was coined by Jurg Tschopp in 2002. Recently, significant research has focused on activating inflammasomes and their roles in disease processes. The NLRP1, NLRP3, NLRC4, and AIM2 inflammasomes have been identified as essential. Inflammasomes are a group of proteins that are part of the innate immune system and play a role in the pathogenesis of periodontal diseases. They are activated by bacteria, which leads to the production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6). Periodontitis is triggered by these cytokines, leading to increased inflammation and tissue destruction. This review aimed to examine how these inflammasomes contribute to periodontitis pathogenesis.

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Targeting inflammasomes: A possible therapeutic approach for periodontal disease (Review)

Cited by 4 publications

References 50 publications

Oral cleaning habits and the copy number of periodontal bacteria in pregnant women and its correlation with birth outcomes: an epidemiological study in Mibilizi, Rwanda

Oral cleaning habits and the copy number of periodontal bacteria in pregnant women and its correlation with birth outcomes: an epidemiological study in Mibilizi, Rwanda

Possible Role of Inflammasomes in the Pathogenesis of Periodontal Diseases

The role of inflammasomes in periodontal disease and pathogenesis

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