Targeting excessive free radicals with peels and juices of citrus fruits: Grapefruit, lemon, lime and orange

Guimarães, Rafaela; Barros, Lillian; Barreira, João C.M.; Sousa, Maria João; Ferreira, Isabel C.F.R.

doi:10.1016/j.fct.2009.09.022

Cited by 212 publications

(114 citation statements)

References 27 publications

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“…Some authors have even reported that the total polyphenol content in the peeled lemons and their peels are significantly higher than those in oranges and grapefruits, peeled and peels, respectively [38]. In addition, total phenolics and total flavonoid content were still significantly higher in the skin than those in the pulp for all citrus fruits, in accordance with previous studies [40,41]. Therefore, citrus peels have been widely studied because they contain many biologically active compounds, including natural antioxidants such as phenolic acids and flavonoids [42,43].…”

Section: Polyphenols and Flavonoids Contentsupporting

confidence: 79%

Evaluation of In-vitro Antidiabetic and Hypolipidaemic Activities of Extracts Citrus Lemon Fruit

Basli¹,

Younici²,

Benkerrou³

et al. 2016

JESE-A

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Citrus genus is the most important fruit tree crop in the world and lemon is the third most important Citrus species. The evaluation of the potential inhibitory activity on α-amylase and pancreatic lipase by Citrus lemon fruits of Algerian origin aiming for new applications of the fruits in nutrition and health was carried out. Lemon fruit EtOAc (ethyl acetate) extract showed higher contents of phytochemicals such as total phenolics and flavonoids. Furthermore, lemon fruit showed higher potential for inhibitory effects on α-amylase and pancreatic lipase. It could be concluded that lemon fruits are of great value for nutrition and treatment of diet-related diseases such as obesity and diabetes.

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Section: Polyphenols and Flavonoids Contentsupporting

confidence: 79%

Evaluation of In-vitro Antidiabetic and Hypolipidaemic Activities of Extracts Citrus Lemon Fruit

Basli¹,

Younici²,

Benkerrou³

et al. 2016

JESE-A

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“…Furthermore, these compounds were found to be potent inhibitors of debenzylation activity of CYP3A4 enzyme. Guimarã es et al [31], studied a comparison between the antioxidant properties of peel (flavedo and albedo) and juices of citrus fruit (Rutaceae), grapefruit (Citrus paradisi), lemon (Citrus limon), lime (Citrus xaurantiifolia) and sweet orange (Citrus sinensis) and found that phenolics were the main antioxidant compounds found in all the extracts. The dominant flavanone glycoside in grapefruit is naringin.…”

Section: Discussionmentioning

confidence: 99%

Rytmonorm-Induced Cytogenetic and Testicular Damage in Albino Rats: The Protective Effect of Grapefruit Juice

Sakr¹,

Zoail²,

El-Shafey³

2013

AJBR

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The present work studied the cytogenetic and testicular damage induced by the antiarrhythmic drug rytmonorm (RT) and the protective role of grapefruit juice in albino rats. Treating rats with RT (13.5mg/Kg bodyweight) for five weeks caused a significant increase in the percentage of chromosomal aberrations either structural or numerical and decrease the mitotic index. Using comet assays, RT caused DNA fragmentation in the lymphocytes. Testis of RT treated rats showed many histopathological and morphometric alterations. In addition, the number of sperm head abnormalities was increased. Treating animals with RT and grapefruit juice (27ml/Kg bodyweight) led to an improvement in chromosomal aberrations, mitotic index, DNA damage, and testicular alterations caused by RT. In conclusion, the results of this study indicated that grapefruit juice showed a protective effect on cytotoxicty and testicular alterations induced by RT in albino rats and this is may be due to its potent antioxidant effects.

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“…Apesar disso, na fase C tanto o TBARS total como o livre se comportou de maneira constante, enquanto nas fases D e S houve diminuição dos níveis após o exercício, ou seja, maiores níveis de vitamina C séricos nestas duas fases foram suficientes para conter a peroxidação. Enquanto FOX, outro marcador de peroxidação lipídica com ação nos hidroperóxidos, foi menor com o uso de dieta rica em AA, sugerindo que dieta rica em AA permite tirar vantagem em relação ao uso de um suplemento de AA, pelo efeito aditivo e sinérgico dos fenólicos que favorecem uma maior concentração de antioxidantes 28,29 . Em relação aos níveis séricos de antioxidantes, apenas a vitamina C apresentou variação com o exercício, enquanto as concentrações de vitamina E e GSH não modificaram em decorrência do mesmo.…”

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Efeitos do ácido ascórbico nos biomarcadores de estresse oxidativo em nadadores de elite

Garlipp-Picchi

Deminice

Ovídio

et al. 2013

Rev Bras Med Esporte

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RESuMoObjetivo: O objetivo do estudo foi verificar os efeitos da oferta de vitamina C através de um suplemento alimentar e dieta rica em ácido ascórbico (AA) no estresse oxidativo induzido pelo exercício. Métodos: A amostra foi composta por 13 nadadores de elite (seis homens e sete mulheres) com idades entre 18 e 26 anos. Os mesmos atletas foram submetidos a sessão de exercício agudo em três fases, com diferentes tratamentos: controle (C), dieta rica em AA (D) e suplemento de AA (S), nas quais amostras de sangue foram colhidas antes, imediatamente após e 24 horas depois do exercício. Para comparação entre as fases e etapas foi utilizado o modelo de regressão linear com efeitos mistos. Resultados: O consumo alimentar habitual de antioxidantes não foi diferente entre as fases, apenas a ingestão de AA foi maior na fase D e S em relação à fase C. O uso de dieta rica em AA favoreceu uma menor peroxidação lipídica, devido aos menores valores de hidroperóxidos lipídicos (FOX), diminuição da peroxidação após exercício, pela diminuição de substâncias reativas ao ácido tiobarbitúrico (TBARS) e aumento dos níveis de vitamina C logo após o exercício. O uso de suplemento de AA também conteve a peroxidação lipídica após exercício e aumentou o poder antioxidante, devido aos maiores níveis de glutationa reduzida (GSH). Sem adição de AA os nadadores tiveram um maior dano hepático, pois apresentaram maiores níveis de transaminase--glutâmico-oxalacética (TGO), menores níveis de antioxidantes (vitamina C e GSH) e aumento do ácido úrico. Conclusão: Assim, as mudanças observadas com a adição de AA à dieta de nadadores sugerem um importante papel deste micronutriente na defesa contra o estresse oxidativo induzido pelo exercício. (vitamin C and GSH) Palavras consumption of antioxidants did not differ between phases, except that AA intake was higher during the D and S phases than during the C phase. The use of an AA-rich diet provided lower lipid peroxidation due to lower lipid hydroperoxide (FOX) values, a reduction of peroxidation after exercise due to reduction of thiobarbituric acid reactive substances (TBARS), and an increase in vitamin C levels after exercise. The use of an AA supplement also restricted lipid peroxidation after exercise and increased the antioxidant power due to higher levels of reduced glutathione (GSH). Without the addition of AA , the swimmers had greater hepatic damage as shown by higher levels of aspartate aminotransferase (AST), lower antioxidant levels

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Targeting excessive free radicals with peels and juices of citrus fruits: Grapefruit, lemon, lime and orange

Cited by 212 publications

References 27 publications

Evaluation of In-vitro Antidiabetic and Hypolipidaemic Activities of Extracts Citrus Lemon Fruit

Evaluation of In-vitro Antidiabetic and Hypolipidaemic Activities of Extracts Citrus Lemon Fruit

Rytmonorm-Induced Cytogenetic and Testicular Damage in Albino Rats: The Protective Effect of Grapefruit Juice

Efeitos do ácido ascórbico nos biomarcadores de estresse oxidativo em nadadores de elite

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