Targeting Endoplasmic Reticulum Stress as an Effective Treatment for Alcoholic Pancreatitis

Abstract

Pancreatitis and alcoholic pancreatitis are serious health concerns, and there is an urgent need for effective treatment strategies. Alcohol is a known etiological factor for pancreatitis, including acute pancreatitis (AP) and chronic pancreatitis (CP). Excessive alcohol consumption induces many pathological stress responses; of particular note is endoplasmic reticulum (ER) stress and adaptive unfolded protein response (UPR). ER stress results from the accumulation of unfolded/misfolded protein in the ER and is implicated in the pathogenesis of alcoholic pancreatitis. Here we summarize the possible mechanisms by which ER stress contributes to alcoholic pancreatitis. We also discuss potential approaches targeting ER stress and UPR for developing novel therapeutic strategies for the disease.

The role of phosphorus-calcium homeostasis and vitamin D in the pathogenesis of acute pancreatitis and assessment of its severity

“…This trend is observed in most cases of the disease caused by a number of different cau s es (hypoxia, hyperlipidemia, pharmacological drugs with established dependence on the development of pancreatitis (tetracyclines, thiazides, etc. ), alcohol) [13]. At the same time, serum calcium below 1.97 mmol/l is included as a criterion in most international scales for assessing the severity and prediction of acute pancreatitis with fairly high sensitivity (89.7%) [14].…”