Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma

Tribble, James R.; Hui, Flora; Jöe, Melissa; Bell, Katharina; Chrysostomou, Vicki; Crowston, Jonathan G; Williams, Pete A.

doi:10.3390/cells10020295

Cited by 30 publications

(30 citation statements)

References 198 publications

(233 reference statements)

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“…Many other studies that evaluated different antioxidant strategies in experimental or clinical studies detected mild to moderate protection against glaucoma, which were reviewed in detail elsewhere [95]. Clinical studies testing different nutrients or multivitamin complexes with antioxidant capacity are also reviewed in this Special Issue [96]. Experimental observations support the potential of antioxidants to provide neuroprotection and immunomodulation in glaucoma.…”

Section: Mitochondrial Dysfunction and Oxidative Stressmentioning

confidence: 99%

“…Thus, owing to the broad impacts of oxidative stress in both direct injury to RGCs and secondary neurodegenerative outcomes of neuroinflammation, antioxidants may offer a multitarget strategy for glaucoma treatment, which warrant further investigation. Although multiple experimental or clinical studies tested short-term protective outcomes of different antioxidant strategies [95,96], immunomodulatory outcomes remain elusive.…”

Section: Interplay Between Mitochondrial Dysfunction and Neuroinflammationmentioning

confidence: 99%

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Multifactorial Pathogenic Processes of Retinal Ganglion Cell Degeneration in Glaucoma towards Multi-Target Strategies for Broader Treatment Effects

Tezel

2021

Cells

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Glaucoma is a chronic neurodegenerative disease characterized by apoptosis of retinal ganglion cell (RGC) somas, degeneration of axons, and loss of synapses at dendrites and axon terminals. Glaucomatous neurodegeneration encompasses multiple triggers, multiple cell types, and multiple molecular pathways through the etiological paths with biomechanical, vascular, metabolic, oxidative, and inflammatory components. As much as intrinsic responses of RGCs themselves, divergent responses and intricate interactions of the surrounding glia also play decisive roles for the cell fate. Seen from a broad perspective, multitarget treatment strategies have a compelling pathophysiological basis to more efficiently manipulate multiple pathogenic processes at multiple injury sites in such a multifactorial neurodegenerative disease. Despite distinct molecular programs for somatic and axonal degeneration, mitochondrial dysfunction and glia-driven neuroinflammation present interdependent processes with widespread impacts in the glaucomatous retina and optic nerve. Since dysfunctional mitochondria stimulate inflammatory responses and proinflammatory mediators impair mitochondria, mitochondrial restoration may be immunomodulatory, while anti-inflammatory treatments protect mitochondria. Manipulation of these converging routes may thus allow a unified treatment strategy to protect RGC axons, somas, and synapses. This review presents an overview of recent research advancements with emphasis on potential treatment targets to achieve the best treatment efficacy to preserve visual function in glaucoma.

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Section: Mitochondrial Dysfunction and Oxidative Stressmentioning

confidence: 99%

Section: Interplay Between Mitochondrial Dysfunction and Neuroinflammationmentioning

confidence: 99%

Multifactorial Pathogenic Processes of Retinal Ganglion Cell Degeneration in Glaucoma towards Multi-Target Strategies for Broader Treatment Effects

Tezel

2021

Cells

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“…The concept of “food is medicine” has been considered an important measure in prevention, management, and treatment of chronic diseases, which was proven by several epidemiological studies and case reports ( Downer et al, 2020 ; Goldenberg et al, 2021 ; Tribble et al, 2021 ). The integration of foods with clinical practice will help gain a better prognosis, lower medical expenditure, and more general public health recommendations ( Lee et al, 2019 ).…”

Section: Toward the Futurementioning

confidence: 99%

Therapeutic Effects of Melatonin on Ocular Diseases: Knowledge Map and Perspective

Wang

et al. 2021

Front. Pharmacol.

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Melatonin plays a critical role in the pathophysiological process including circadian rhythm, apoptosis, and oxidative stress. It can be synthesized in ocular tissues, and its receptors are also found in the eye, triggering more investigations concentrated on the role of melatonin in the eye. In the past decades, the protective and therapeutic potentials of melatonin for ocular diseases have been widely revealed in animal models. Herein, we construct a knowledge map of melatonin in treating ocular diseases through bibliometric analysis and review its current understanding and clinical evidence. The overall field could be divided into twelve topics through keywords co-occurrence analysis, in which the glaucoma, myopia, and retinal diseases were of greatest research interests according to the keywords burst detection. The existing clinical trials of melatonin in ocular diseases mainly focused on the glaucoma, and more research should be promoted, especially for various diseases and drug administration. We also discuss its bioavailability and further research topics including developing melatonin sensors for personalized medication, acting as stem cell therapy assistant drug, and consuming food-derived melatonin for facilitating its clinical transformation.

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“…Diverse treatment strategies are being tested for their efficacy tin rescuing RGCs from cell death, such as dietary modifications, electrical stimulation therapy, immunomodulatory strategies or gene therapy [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. At late stages of the disease, the only treatment option is a functional replacement of the lost RGCs.…”

Section: Introductionmentioning

confidence: 99%

Cell-Based Neuroprotection of Retinal Ganglion Cells in Animal Models of Optic Neuropathies

Grodzki

Bartsch

et al. 2021

Biology

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Retinal ganglion cells (RGCs) comprise a heterogenous group of projection neurons that transmit visual information from the retina to the brain. Progressive degeneration of these cells, as it occurs in inflammatory, ischemic, traumatic or glaucomatous optic neuropathies, results in visual deterioration and is among the leading causes of irreversible blindness. Treatment options for these diseases are limited. Neuroprotective approaches aim to slow down and eventually halt the loss of ganglion cells in these disorders. In this review, we have summarized preclinical studies that have evaluated the efficacy of cell-based neuroprotective treatment strategies to rescue retinal ganglion cells from cell death. Intraocular transplantations of diverse genetically nonmodified cell types or cells engineered to overexpress neurotrophic factors have been demonstrated to result in significant attenuation of ganglion cell loss in animal models of different optic neuropathies. Cell-based combinatorial neuroprotective approaches represent a potential strategy to further increase the survival rates of retinal ganglion cells. However, data about the long-term impact of the different cell-based treatment strategies on retinal ganglion cell survival and detailed analyses of potential adverse effects of a sustained intraocular delivery of neurotrophic factors on retina structure and function are limited, making it difficult to assess their therapeutic potential.

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Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma

Cited by 30 publications

References 198 publications

Multifactorial Pathogenic Processes of Retinal Ganglion Cell Degeneration in Glaucoma towards Multi-Target Strategies for Broader Treatment Effects

Multifactorial Pathogenic Processes of Retinal Ganglion Cell Degeneration in Glaucoma towards Multi-Target Strategies for Broader Treatment Effects

Therapeutic Effects of Melatonin on Ocular Diseases: Knowledge Map and Perspective

Cell-Based Neuroprotection of Retinal Ganglion Cells in Animal Models of Optic Neuropathies

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