Targeting cancer cells with nanotherapeutics and nanodiagnostics: Current status and future perspectives

Ali, Eunüs S.; Sharker, Shazid Md.; Islam, Muhammad Torequl; Khan, Ishaq N.; Shaw, Subrata; Rahman, Md. Atiqur; Uddin, Shaikh Jamal; Shill, Manik Chandra; Rehman, Shahnawaz; Das, Niranjan; Ahmad, Saheem; Shilpi, Jamil A.; Tripathi, Swati; Mishra, Siddhartha; Mubarak, Mohammad S.

doi:10.1016/j.semcancer.2020.01.011

Cited by 140 publications

(56 citation statements)

References 192 publications

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“…Growing evidence suggests that the combination of phytochemicals with synthetic agents may serve as an effective anticancer therapeutic strategy including stress or drug-induced apoptotic signaling in tumor cells mediated through lipid rafts ( Gajate et al, 2009 ; Leto et al, 2009 ; Bae et al, 2011 ; Ali et al, 2020 ). Reportedly, cancer cell lipid composition differs from the non-malignant cell profile but is variable between malignancy types ( Bernardes and Fialho, 2018 ; Casares et al, 2019 ; Pakiet et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Sesquiterpene Alcohol Cedrol Chemosensitizes Human Cancer Cells and Suppresses Cell Proliferation by Destabilizing Plasma Membrane Lipid Rafts

Mishra

Lee

Kim

et al. 2021

Front. Cell Dev. Biol.

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Chemosensitization of cancer cells with small molecules may improve the therapeutic index of antitumoral agents by making tumor cells sensitive to the drug regimen and thus overcome the treatment resistance and side effects of single therapy. Cell membrane lipid rafts are known to transduce various signaling events in cell proliferation. Sensitizing cancer cells may cause modulation of membrane lipid rafts which may potentially be used in improving anticancer drug response. Cedrol, a natural sesquiterpene alcohol, was used to treat human leukemia K562 and colon cancer HT-29 cell lines, and effects were observed. Cedrol decreased the cell viability by inducing apoptosis in both cell lines by activation of pro-apoptosis protein BID and inhibition of anti-apoptosis proteins Bcl-XL, Bcl-2, and XIAP. Cedrol activated the caspase-9-dependent mitochondrial intrinsic pathway of apoptosis. Furthermore, cedrol inhibited the levels of pAKT, pERK, and pmTOR proteins as well as nuclear and cytoplasmic levels of the p65 subunit of NF-κB. Cedrol caused redistribution of cholesterol and sphingomyelin contents from membrane lipid raft, which was confirmed by a combined additive effect with methyl-β-cyclodextrin (lipid raft-disrupting agent). Lipid raft destabilization by cedrol led to the increased production of ceramides and inhibition of membrane-bound NADPH oxidase 2 enzyme activity. Cholesterol/sphingomyelin-redistributing abilities of cedrol appear as a novel mechanism of growth inhibition of cancer cells. Cedrol can be classified as a natural lipid raft-disrupting agent with possibilities to be used in general studies involving membrane lipid raft modifications.

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Section: Discussionmentioning

confidence: 99%

Sesquiterpene Alcohol Cedrol Chemosensitizes Human Cancer Cells and Suppresses Cell Proliferation by Destabilizing Plasma Membrane Lipid Rafts

Mishra

Lee

Kim

et al. 2021

Front. Cell Dev. Biol.

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“…Nanomedicine commercialization requires a large investment, 134 and the cost-effective benefit is an inevitable issue. 135 Extreme profitability concept leads to concerns that global equality in access to health care might be even further compromised. Continuous efforts to cultivate cost-effective nanomedicine with more security are mandatory to make better use of nanotechnologies for global welfare.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Nanomedicine-Based Therapeutics to Combat Acute Lung Injury

Bian¹,

Cai²,

Cui³

et al. 2021

IJN

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Acute lung injury (ALI) or its aggravated stage acute respiratory distress syndrome (ARDS) may lead to a life-threatening form of respiratory failure, resulting in high mortality of up to 30-40% in most studies. Although there have been decades of research since ALI was first described in 1967, the clinical therapeutic alternatives for ALI are still in a state of limited availability. Supportive treatment and mechanical ventilation still have priority. Despite some preclinical studies demonstrating the benefit of pharmacological interventions, none of these has been proved completely effective to date. Recent advances in nanotechnology may shed new light on the pharmacotherapy of ALI. Nanomedicine possesses targeting and synergistic therapeutic capability, thus boosting pharmaceutical efficacy and mitigating the side effects. Currently, a variety of nanomedicine with diverse frameworks and functional groups have been elaborately developed, in accordance with their lung targeting ability and the pathophysiology of ALI. The in-depth review of the current literature reveals that liposomes, polymers, inorganic materials, cell membranes, platelets, and other nanomedicine approaches have conferred attractive therapeutic benefits for ALI treatment. In this review, we explore the recent progress in the study of the nanomedicinebased therapy of ALI, presenting various nanomedical approaches, drug choices, therapeutic strategies, and outcomes, thereby providing insight into the trends.

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“…Moreover, there are chemodynamic therapy (CDT) [78,79], sonodynamic therapy (SDT) [39,80], magnetic resonance imaging (MRI) [65,81] and photoacoustic imaging (PAI) [82] induced by physiochemical properties of material itself. They are frequently used in combination with conventional methods for cancer diagnosis, imaging and treatment because of noninvasive processes, enhanced spatiotemporal control, less time-consuming and more precise effect, termed "nanotheranostic" [83][84][85][86]. Yang et al took advantages in semiconducting materials with strong near-infrared absorption to establish the perylene diimide (PDI)-based theranostic NP.…”

Section: Tumor Chemotherapymentioning

confidence: 99%

Nanotechnologies for enhancing cancer immunotherapy

et al. 2020

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Immunotherapy, a burgeoning field differs from traditional cancer treatments, is revolutionizing oncologic therapeutics. It aims to stimulate the innate and adaptive immune system of a patient to fight against tumor cells. However, low response rate and immune-related adverse effects (irAEs) remain problems during its management. A novel technology using nanomaterials may bring a solution. Various nanoparticles have been investigated as delivery systems to augment cancer therapeutic efficacy in the lab and clinic. In this review, we briefly summarize the connotation of immunotherapy, the application of nanotechnology in cancer, especially focusing on the synergistic effect of nanoplatform-based technology combined with cancer immunotherapy, hoping to make readers a deep insight into this interdisciplinary field.

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Targeting cancer cells with nanotherapeutics and nanodiagnostics: Current status and future perspectives

Cited by 140 publications

References 192 publications

Sesquiterpene Alcohol Cedrol Chemosensitizes Human Cancer Cells and Suppresses Cell Proliferation by Destabilizing Plasma Membrane Lipid Rafts

Sesquiterpene Alcohol Cedrol Chemosensitizes Human Cancer Cells and Suppresses Cell Proliferation by Destabilizing Plasma Membrane Lipid Rafts

Nanomedicine-Based Therapeutics to Combat Acute Lung Injury

Nanotechnologies for enhancing cancer immunotherapy

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