Nanotechnologies for enhancing cancer immunotherapy

Yang, Jingxian; Wang, Chunhui; Shi, Shuo; Dong, Chunyan

doi:10.1007/s12274-020-2904-8

Cited by 25 publications

(22 citation statements)

References 213 publications

(323 reference statements)

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“…Following by the FDA approval of certain ICIs, therapeutic cancer vaccine and chimeric antigen receptor (CAR)-T cell therapy, the 2018 Nobel Prize in Physiology or Medicine implied that immunotherapy for cancer is regarded as a potentially potent therapy in the next decades ( 8 ). Anti-PD-1/PD-L1 mAbs are currently the most explored and marketed immunotherapy agents.…”

Section: Discussionmentioning

confidence: 99%

Immune Myocarditis Overlapping With Myasthenia Gravis Due to Anti-PD-1 Treatment for a Chordoma Patient: A Case Report and Literature Review

et al. 2021

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Immunotherapy begins to be widely used due to the increasing exploration and gratifying effects in multiple cancers. Chordoma, as a rare bone malignant tumor, often recurs and metastasizes after undergoing surgery and radiotherapy. Therefore, immunotherapy can be explored as an emerging, potentially effective treatment to improve the survival rate and clinical benefit of patients. However, a variety of immune-related adverse events (irAEs) cannot be avoided completely. And the immunotherapy-induced myocarditis, as a rare but fatal irAE, has been increasingly reported. Understanding the mechanism involved in irAEs can inform best practices for side effects management. Here, we firstly reported a case of immune myocarditis and subsequent myasthenia gravis (MG) following anti-PD-1 treatment for chordoma.

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Section: Discussionmentioning

confidence: 99%

Immune Myocarditis Overlapping With Myasthenia Gravis Due to Anti-PD-1 Treatment for a Chordoma Patient: A Case Report and Literature Review

et al. 2021

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“…The immunosuppressive microenvironment is one of the main reasons for the poor antitumor effect in vivo [ 87 ]. For M2 macrophages, the most popular methods are reducing M2 macrophages, blocking the immune suppressive function of M2 by blocking PD-1/PD-L1 and the CD47-SIRPα axis [ 88 ].…”

Section: Microenvironment-targeted Nano-delivery System As a Promising Strategymentioning

confidence: 99%

Exploiting a New Approach to Destroy the Barrier of Tumor Microenvironment: Nano-Architecture Delivery Systems

Sun

Shi

et al. 2021

Molecules

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Recent findings suggest that tumor microenvironment (TME) plays an important regulatory role in the occurrence, proliferation, and metastasis of tumors. Different from normal tissue, the condition around tumor significantly altered, including immune infiltration, compact extracellular matrix, new vasculatures, abundant enzyme, acidic pH value, and hypoxia. Increasingly, researchers focused on targeting TME to prevent tumor development and metastasis. With the development of nanotechnology and the deep research on the tumor environment, stimulation-responsive intelligent nanostructures designed based on TME have attracted much attention in the anti-tumor drug delivery system. TME-targeted nano therapeutics can regulate the distribution of drugs in the body, specifically increase the concentration of drugs in the tumor site, so as to enhance the efficacy and reduce adverse reactions, can utilize particular conditions of TME to improve the effect of tumor therapy. This paper summarizes the major components and characteristics of TME, discusses the principles and strategies of relevant nano-architectures targeting TME for the treatment and diagnosis systematically.

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“…In contrast, immunoassays such as enzyme-linked immunosorbent assay (ELISA) and immunochromatographic assay (ICA), are time saving, convenient and economic, and they have been widely applied to food quality control [9][10][11][12][13][14][15], disease diagnosis [16][17][18][19][20][21][22][23][24][25] and environmental pollutant analysis [26][27][28][29][30]. Several immunoassays have also been developed for the determination of triazines (Table 1) [31][32][33][34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Multiple detection of 15 triazine herbicides by gold nanoparticle based-paper sensor

Guo

Zhao

et al. 2022

Nano Res.

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Triazine herbicides have been widely used in agriculture, but their residues can harm the environment and human health. To help monitor these, we have developed an effective immunochromatographic strip test that can simultaneously detect 15 different triazines in grain samples (including ametryn, cyprazine, atraton, prometon, prometryn, atrazine, propazine, terbuthylazine, simetryn, trietazine, secbumeton, simazine, desmetryn, terbumeton and simetone). Based on our optimization procedure, the visual limit of detection (vLOD) for these triazines was found to be 2–10 ng/mL in assay buffer, and 0.02−0.1 mg/kg in grain samples. Four different grain matrices including corn, brown rice, wheat, and sorghum were studied and the test results showed no significant differences between the 15 triazines analyzed using this method. This test is simple, convenient, rapid, and low-cost, and could be an effective tool for primary screening of triazine residues in grain samples. Electronic Supplementary Material Supplementary material (UV–vis spectra of 15 nm-GNP; K2CO3 usage; cross reactivity; strip images for spiked rice, wheat and sorghum samples, UPLC-MS/MS parameters; gray values for strip optimization) is available in the online version of this article at 10.1007/s12274-022-4164-2.

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Nanotechnologies for enhancing cancer immunotherapy

Cited by 25 publications

References 213 publications

Immune Myocarditis Overlapping With Myasthenia Gravis Due to Anti-PD-1 Treatment for a Chordoma Patient: A Case Report and Literature Review

Immune Myocarditis Overlapping With Myasthenia Gravis Due to Anti-PD-1 Treatment for a Chordoma Patient: A Case Report and Literature Review

Exploiting a New Approach to Destroy the Barrier of Tumor Microenvironment: Nano-Architecture Delivery Systems

Multiple detection of 15 triazine herbicides by gold nanoparticle based-paper sensor

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