Targeting cancer cells: magnetic nanoparticles as drug carriers

Alexiou, Christoph; Schmid, Roswitha J.; Jurgons, Roland; Kremer, Marcus; Wanner, Gerhard; Bergemann, Christian; Huenges, Ernst; Nawroth, Thomas; Arnold, W.; Parak, F.

doi:10.1007/s00249-006-0042-1

Cited by 343 publications

(203 citation statements)

References 4 publications

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“…10 Several approaches to improving the selective toxicity of anticancer therapeutics are being pursued presently. [32][33][34] The most commonly used method is Core-shell nanoparticles of Au@silica were synthesized using gold nanoparticles as templates. The porosity of silica shells is regulated by adding 3-aminopropyltrimethoxysilane.…”

Section: Nanoparticles/nanocapsules As Drug Delivery Carriers To Cancermentioning

confidence: 99%

“…41,42 Recently, the research of Alexiou et al showed that magnetic drug targeting employing nanoparticles as carriers is a promising system for cancer treatment that does not cause side effects commonly observed in conventional chemotherapy. 32 They used iron oxide nanoparticles covered with starch derivatives with phosphate groups that bind to mitoxantrone, a chemotherapeutical agent. It was demonstrated that a strong-magnetic-field gradient at a tumor site induces the accumulation of nanoparticles, and ferrofluids can become abundant in tumor tissue and tumor cells (Fig.…”

Section: Nanoparticles/nanocapsules As Drug Delivery Carriers To Cancermentioning

confidence: 99%

See 1 more Smart Citation

Nanomedicine for drug delivery and imaging: A promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles

Liu

Miyoshi

Nakamura

2007

Intl Journal of Cancer

566

340

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The diagnosis and treatment of cancer or tumor at the cellular level will be greatly improved with the development of techniques that enable the delivery of analyte probes and therapeutic agents into cells and cellular compartments. Organic and inorganic nanoparticles that interface with biological systems have recently attracted widespread interest in the fields of biology and medicine. The new term nanomedicine has been used recently. Nanoparticles are considered to have the potential as novel intravascular or cellular probes for both diagnostic (imaging) and therapeutic purposes (drug/gene delivery), which is expected to generate innovations and play a critical role in medicine. Target-specific drug/ gene delivery and early diagnosis in cancer treatment is one of the priority research areas in which nanomedicine will play a vital role. Some recent breakthroughs in this field recently also proved this trend. Nanoparticles for drug delivery and imaging have gradually been developed as new modalities for cancer therapy and diagnosis. In this article, we review the significance and recent advances of gene/drug delivery to cancer cells, and the molecular imaging and diagnosis of cancer by targeted functional nanoparticles. ' 2007 Wiley-Liss, Inc.

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Section: Nanoparticles/nanocapsules As Drug Delivery Carriers To Cancermentioning

confidence: 99%

Section: Nanoparticles/nanocapsules As Drug Delivery Carriers To Cancermentioning

confidence: 99%

Nanomedicine for drug delivery and imaging: A promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles

Liu

Miyoshi

Nakamura

2007

Intl Journal of Cancer

566

340

View full text Add to dashboard Cite

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“…In this context, most studies refer to mitoxantrone (e.g. [1]) or doxorubicin (e.g. [34]) as chemotherapeutic agent.…”

Section: Design Of Mnps As Multifunctional Tools For Magnetic Hyperthmentioning

confidence: 99%

Means to increase the therapeutic efficiency of magnetic heating of tumors

Kettering

Grau

Pömpner

et al. 2015

Biomedical Engineering / Biomedizinische Technik

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Abstract:The treatment of tumors via hyperthermia has gained increased attention in the last years. Among the different modalities available so far, magnetic hyperthermia has the particular advantage of offering the possibility of depositing the heating source directly into the tumor. In this study, we summarized the present knowledge we gained on how to improve the therapeutic efficiency of magnetic hyperthermia using magnetic nanoparticles (MNPs), with particular consideration of the intratumoral infiltration of the magnetic material. We found that (1) MNPs will be mainly immobilized at the tumor area and that this aspect has to be considered when estimating the heating potential of MNPs, (2) the intratumoral distribution patterns via slow infiltration might well be modulated by specific MNP coating and magnetic targeting, (3) imaging of the nanoparticle depositions within the tumor might allow to correct the distribution pattern via multiple applications, (4) multiple therapeutic sessions are feasible because MNPs are not delivered from the tumor site during the heating process, (5) the utilization of MNPs that internalize into cells will favor the production of intracellular heating spots rather than extracellular ones, (6) utilization of MNPs functionalized with chemotherapeutic agents will allow us to exploit the additive effects of both therapeutic modalities, and (7) distinct cytopathological and histopathological alterations in target tissues are induced as a result of magnetic hyperthermia. However, the accumulation at the tumor via intravenous application remains a matter of challenge.

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“…Inorganic material allows the production of porous or mesoporous nanoparticles with particle size in range of 50 -300 nm and the pore diameter in the range 5 -50 nm. The porous structure allows high loading capacity for the therapeutic agents and/or tracers, like fluorescein, radioactive compounds or paramagnetic iron (Wiekhorst et al 2006, Alexiou et al 2006a, Alexiou et al 2006b). …”

Section: Nanoparticlesmentioning

confidence: 99%