Targeting androgen receptor signaling with MicroRNAs and Curcumin: a promising therapeutic approach for Prostate Cancer Prevention and intervention

Abstract

Prostate cancer (PC) is a multifactorial disease characterized by the abrogation of androgen receptor signaling. Advancement in microbiology techniques has highlighted the significant role of microRNAs (miRNAs) in the progression of PC cells from an androgen-dependent to an androgen-independent state. At that stage, prostate tumors also fail to respond to currently practiced hormone therapies. So, studies in recent decades are focused on investigating the anti-tumor effects of natural compounds in PC. Curcumin is widely recognized and now of huge prestige for its anti-proliferative abilities in different types of cancer. However, its limited solubility, compatibility, and instability in the aqueous phase are major hurdles when administering. Nanoformulations have proven to be an excellent drug delivery system for various drugs and can be used as potential delivery platforms for curcumin in PC. In this review, a shed light is given on the miRNAs-mediated regulation of androgen receptor (AR) signaling and miRNA-curcumin interplay in PC, as well as on curcumin-based nanoformulations that can be used as possible therapeutic solutions for PC.

Effects of curcumin and soy isoflavones on genomic instability of human colon cells NCM460 and SW620

“…Furthermore, it has also received attention from researchers due to its broad-spectrum antitumor activity. Some researchers have confirmed that it can prevent and treat prostate cancer by targeting the androgen receptor pathway (35). Both in vivo and vitro experiments have confirmed that it can improve the degree of genomic methylation in breast cancer cell lines (MDA-MB-231, MCF-7, T47D, etc.…”

Antiradical and Antioxidant Activity of Compounds Containing 1,3-Dicarbonyl Moiety: An Overview

“…Since ancient times, the benefits of phytochemical curcumin have been applied in traditional medicine [47]. In recent years, several reviews highlighting various biological activities of curcumin have seen the light of day, indicating that curcumin is a green anticancer weapon [48][49][50][51][52][53][54]. The wide application of curcumin in cancer therapy has forced Kong et al [55] to ask whether "curcumin is the answer to future chemotherapy cocktail?".…”

A comprehensive analysis of ncRNA-mediated interactions reveals potential prognostic biomarkers in prostate adenocarcinoma

“…Many studies have validated some genes and related pathways contribute to PRAD, and some crucial genes may be potential biomarkers for diagnosis and treatment [8] , especially for non-coding RNAs (ncRNAs). As a class of potential important regulators, mainly including microRNA (miRNA), long-non-coding RNA (lncRNA) and circular RNAs (circRNA), has been widely concerned due to the key roles with mRNAs in ncRNA regulatory network.…”