Targeting and synergistic action of an antifungal peptide in an antibiotic drug-delivery system

Park, Seong-Cheol; Kim, Young‐Min; Lee, Jong-Kook; Kim, Nam-Hong; Kim, Young Ho; Heo, Heeok; Lee, Min Young; Lee, Jung Ro; Jang, Mi-Kyeong

doi:10.1016/j.jconrel.2017.04.023

Cited by 33 publications

(23 citation statements)

References 50 publications

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“…Diverse pre-clinical delivery tools and formulations are being studied. In one case, Park et al developed a pH-responsive and redox-sensitive polymer-based AmB-delivery carrier system (Park et al, 2017), by conjugation with histatin 5 acting both as a synergistic antifungal molecule and a targeting ligand against C. albicans. Other authors describe that some properties of the peptides could make them suitable for self-delivery systems.…”

Section: Delivery and Formulationsmentioning

confidence: 99%

Antifungal Peptides as Therapeutic Agents

Ullivarri

Arbulu

García-Gutiérrez

et al. 2020

Front. Cell. Infect. Microbiol.

165

132

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Fungi have been used since ancient times in food and beverage-making processes and, more recently, have been harnessed for the production of antibiotics and in processes of relevance to the bioeconomy. Moreover, they are starting to gain attention as a key component of the human microbiome. However, fungi are also responsible for human infections. The incidence of community-acquired and nosocomial fungal infections has increased considerably in recent decades. Antibiotic resistance development, the increasing number of immunodeficiency-and/or immunosuppression-related diseases and limited therapeutic options available are triggering the search for novel alternatives. These new antifungals should be less toxic for the host, with targeted or broader antimicrobial spectra (for diseases of known and unknown etiology, respectively) and modes of actions that limit the potential for the emergence of resistance among pathogenic fungi. Given these criteria, antimicrobial peptides with antifungal properties, i.e., antifungal peptides (AFPs), have emerged as powerful candidates due to their efficacy and high selectivity. In this review, we provide an overview of the bioactivity and classification of AFPs (natural and synthetic) as well as their mode of action and advantages over current antifungal drugs. Additionally, natural, heterologous and synthetic production of AFPs with a view to greater levels of exploitation is discussed. Finally, we evaluate the current and potential applications of these peptides, along with the future challenges relating to antifungal treatments.

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Section: Delivery and Formulationsmentioning

confidence: 99%

Antifungal Peptides as Therapeutic Agents

Ullivarri

Arbulu

García-Gutiérrez

et al. 2020

Front. Cell. Infect. Microbiol.

165

132

View full text Add to dashboard Cite

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“…Actually, weaker interactions between the AMP and the nanoparticle promote a decrease in NP toxicity and, at the same time, increase AMP activity, because it allows the peptide to adopt favorable structure and/or charge properties essential for the interaction with biomembranes (Liu et al, 2013 ; Rajchakit and Sarojini, 2017 ). These AMP-NP complexes also allow a higher concentration of the drug in the site of action, with a selective activity, including a differential interaction between the complex and the outer and inner-membranes of the target bacterial pathogens, implying a drug-delivery and direct activity system (Park et al, 2017 ; Rajchakit and Sarojini, 2017 ).…”

Section: Nanoparticles In Therapeuticsmentioning

confidence: 99%

Application of Light Scattering Techniques to Nanoparticle Characterization and Development

et al. 2018

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Over the years, the scientific importance of nanoparticles for biomedical applications has increased. The high stability and biocompatibility, together with the low toxicity of the nanoparticles developed lead to their use as targeted drug delivery systems, bioimaging systems, and biosensors. The wide range of nanoparticles size, from 10 nm to 1 μm, as well as their optical properties, allow them to be studied using microscopy and spectroscopy techniques. In order to be effectively used, the physicochemical properties of nanoparticle formulations need to be taken into account, namely, particle size, surface charge distribution, surface derivatization and/or loading capacity, and related interactions. These properties need to be optimized considering the final nanoparticle intended biodistribution and target. In this review, we cover light scattering based techniques, namely dynamic light scattering and zeta-potential, used for the physicochemical characterization of nanoparticles. Dynamic light scattering is used to measure nanoparticles size, but also to evaluate their stability over time in suspension, at different pH and temperature conditions. Zeta-potential is used to characterize nanoparticles surface charge, obtaining information about their stability and surface interaction with other molecules. In this review, we focus on nanoparticle characterization and application in infection, cancer and cardiovascular diseases.

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“…Authors suggested that, besides of being the first prospective leishmanicidal peptide with a defined nonstereospecific intracellular accumulation, His 5 might be also developed as a carrier of antimalarian or other drugs for the combined therapy. In continuation of this line, Park et al recently proposed the His 5 modified nanoparicles as a new targeted delivery system for AmB [ 183 ]. Their structure contains water-soluble chitosan-conjugated to His 5 via pH-sensitive and AmB with a redox-sensitive linker.…”

Section: Antifungal Peptidesmentioning

confidence: 99%

Natural Antimicrobial Peptides as Inspiration for Design of a New Generation Antifungal Compounds

Bondaryk

Staniszewska

Zielińska

et al. 2017

JoF

100

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Invasive fungal infections are associated with high mortality rates, despite appropriate antifungal therapy. Limited therapeutic options, resistance development and the high mortality of invasive fungal infections brought about more concern triggering the search for new compounds capable of interfering with fungal viability and virulence. In this context, peptides gained attention as promising candidates for the antimycotics development. Variety of structural and functional characteristics identified for various natural antifungal peptides makes them excellent starting points for design novel drug candidates. Current review provides a brief overview of natural and synthetic antifungal peptides.

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Targeting and synergistic action of an antifungal peptide in an antibiotic drug-delivery system

Cited by 33 publications

References 50 publications

Antifungal Peptides as Therapeutic Agents

Antifungal Peptides as Therapeutic Agents

Application of Light Scattering Techniques to Nanoparticle Characterization and Development

Natural Antimicrobial Peptides as Inspiration for Design of a New Generation Antifungal Compounds

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