Targeted therapeutic delivery using engineered exosomes and its applications in cardiovascular diseases

Dang, Xitong; Zeng, Xiaorong

doi:10.1016/j.gene.2015.08.067

Cited by 118 publications

(87 citation statements)

References 94 publications

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“…Furthermore, since exosomes possess some properties such as biocompatibility, biological barrier permeability, low toxicity and low immunogenicity, which are good for therapeutic delivery [90, 91]. Exogenous miRNAs, siRNAs, and even drugs could be encapsulated into the naïve exosomes or engineered exosomes.…”

Section: Translational Applications Targeting Exosomementioning

confidence: 99%

“…Exogenous miRNAs, siRNAs, and even drugs could be encapsulated into the naïve exosomes or engineered exosomes. The proven technology that packages the therapeutic miRNAs and siRNAs into engineered exosomes could be achieved by the following means: 1) co-transfection into the donor cells with one plasmid or virus encoding the precursor miRNAs or siRNAs, and the other plasmid encoding fusion targeting cassette, respectively [90]; 2) electroporation of synthetic miRNAs or siRNAs into purified exosomes directly [92, 93]; 3) transient transfection of miRNAs by using commercial available transfection reagents [94]. In addition, permeabilization with soponin, sonication, or extrusion could increase the loading efficiency [95].…”

Section: Translational Applications Targeting Exosomementioning

confidence: 99%

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Emerging role of exosome-mediated intercellular communication in vascular remodeling

Xie

et al. 2017

Oncotarget

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Vascular remodeling refers to the alternations of function and structure in vasculature. A complex autocrine/paracrine set of cellular interaction is involved in vascular remodeling. Exosome, a newly identified natural nanocarrier and intercellular messenger, plays a pivotal role in regulating cell-to-cell communication. Exosome emerges as an important mediator in the process of vascular remodeling, showing the most prognostic and therapeutic potent in vascular diseases. Benefiting from exosomal trafficking, the vasculature can not only maintain its function and structure in physiological condition, but also adapt itself in pathological status. In this review, we will represent the roles of exosomes in angiogenesis, endothelial function and cardiac regeneration. In addition, greatly depending on the pathophysiological status of donor cells and peripheral micro-circumstance, the exosomal content could alter, which makes exosomes exhibit pleiotropic effects in vascular diseases. Hence, the diverse effects of exosomes in vascular diseases including atherosclerosis, neointima formation and vascular repair, primary hypertension, pulmonary artery hypertension, and aortic aneurysm will be discussed. Finally, the translational appliances targeting exosomes will be concluded by providing updated applications of engineered exosomes in clinic.

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Section: Translational Applications Targeting Exosomementioning

confidence: 99%

Section: Translational Applications Targeting Exosomementioning

confidence: 99%

Emerging role of exosome-mediated intercellular communication in vascular remodeling

Xie

et al. 2017

Oncotarget

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“…They revealed that miRNAs derived from noncancerous cells can be transferred to cancerous cells, then inhibiting tumor cell proliferation [185]. Furthermore, researchers observed no overt side effects on exosome-mediated gene delivery [186, 187]. These studies indicate that miRNAs which specifically target kinds of FOX proteins can be loaded into exosomes and then be transported to cancer cells and therefore may be developed as possible anticancer drugs.…”

Section: The Microrna/fox Signalings In Cancer Treatmentmentioning

confidence: 99%

MicroRNAs as regulators and mediators of forkhead box transcription factors function in human cancers

Zhang

Chen

et al. 2016

Oncotarget

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Evidence has shown that microRNAs are widely implicated as indispensable components of tumor suppressive and oncogenic pathways in human cancers. Thus, identification of microRNA targets and their relevant pathways will contribute to the development of microRNA-based therapeutics. The forkhead box transcription factors regulate numerous processes including cell cycle progression, metabolism, metastasis and angiogenesis, thereby facilitating tumor initiation and progression. A complex network of protein and non-coding RNAs mediates the expression and activity of forkhead box transcription factors. In this review, we summarize the current knowledge and concepts concerning the involvement of microRNAs and forkhead box transcription factors and describe the roles of microRNAs-forkhead box axis in various disease states including tumor initiation and progression. Additionally, we describe some of the technical challenges in the use of the microRNA-forkhead box signaling pathway in cancer treatment.

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“…The regulatory machinery of exosomes that is associated with production and cellular uptake remains largely unknown. Nonetheless, the engineering of exosomes for therapeutic control of diseases, including cancer, indicated promising results (11)(12)(13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Generation and testing of clinical-grade exosomes for pancreatic cancer

et al. 2018

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Targeted therapeutic delivery using engineered exosomes and its applications in cardiovascular diseases

Cited by 118 publications

References 94 publications

Emerging role of exosome-mediated intercellular communication in vascular remodeling

Emerging role of exosome-mediated intercellular communication in vascular remodeling

MicroRNAs as regulators and mediators of forkhead box transcription factors function in human cancers

Generation and testing of clinical-grade exosomes for pancreatic cancer

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