Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization

Yang, Yihua; Guo, Lin; Wang, Zhe; Liu, Peng; Liu, Xuanjun; Ding, Jinsong; Zhou, Wenhu

doi:10.1016/j.biomaterials.2020.120390

Cited by 253 publications

(194 citation statements)

References 58 publications

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“…In addition, because silver (Ag) has a strong x-ray attenuation compared to iodinated agents used in imaging, there is significant interest in using AgNPs for x-ray computed tomography imaging and other optical imaging applications [26][27][28][29][30][31]. There is also interest in using them as drug delivery agents for cancer therapy [32][33][34] or rheumatoid arthritis therapy [35]. Consequently, it is expected that the increased production and use will lead to a significant accumulation of AgNPs in wastewater and the environment, potentially increasing exposure to humans [36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Silver Nanoparticles Stable to Oxidation and Silver Ion Release Show Size-Dependent Toxicity In Vivo

et al. 2021

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Silver nanoparticles (AgNPs) are widely used in commerce, however, the effect of their physicochemical properties on toxicity remains debatable because of the confounding presence of Ag+ ions. Thus, we designed a series of AgNPs that are stable to surface oxidation and Ag+ ion release. AgNPs were coated with a hybrid lipid membrane comprised of L-phosphatidylcholine (PC), sodium oleate (SOA), and a stoichiometric amount of hexanethiol (HT) to produce oxidant-resistant AgNPs, Ag–SOA–PC–HT. The stability of 7-month aged, 20–100 nm Ag–SOA–PC–HT NPs were assessed using UV–Vis, dynamic light scattering (DLS), and inductively coupled plasma mass spectrometry (ICP-MS), while the toxicity of the nanomaterials was assessed using a well-established, 5-day embryonic zebrafish assay at concentrations ranging from 0–12 mg/L. There was no change in the size of the AgNPs from freshly made samples or 7-month aged samples and minimal Ag+ ion release (<0.2%) in fishwater (FW) up to seven days. Toxicity studies revealed AgNP size- and concentration-dependent effects. Increased mortality and sublethal morphological abnormalities were observed at higher concentrations with smaller nanoparticle sizes. This study, for the first time, determined the effect of AgNP size on toxicity in the absence of Ag+ ions as a confounding variable.

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Section: Introductionmentioning

confidence: 99%

Silver Nanoparticles Stable to Oxidation and Silver Ion Release Show Size-Dependent Toxicity In Vivo

et al. 2021

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“…To improve synovial inflammation, M1 macrophages may progress to an M2 anti-inflammatory macrophage phenotype [148]. Yang et al [148] used folic acid modified with silver nanoparticles (FA-AgNPs) which could be effectively transported into M1 macrophages to stimulate M1 macrophages reduction and then M2 macrophages polarization in order to successful RA therapy. In this model, M1 macrophages were targeted through the folate receptor overexpressed at their cell surface.…”

Section: Silver Npsmentioning

confidence: 99%

“…Liposomes MTX, Dex, SIN Improved controlled release, reduced RA signs, decreased side effects [128] Polymeric NPs Ket, Dex, TFC, MTX Decreased inflammation [134] Niosomes PC, thiocolchicoside, ibuprofen Increased drug retention [143] Silver NPs FA-AgNPs Enhanced anti-inflammatory activities [148] Gold NPs Triam Enhanced anti-inflammatory activities [150] Iron NPs MTX Suppression of joint edema and inflammation [152] Quantum dots celecoxib Localized activity in sites of inflammation [153] Solid lipid NPs CUR, Pi, CIP Enhanced anti-inflammatory activities [154] Polymeric micelles Dex, indomethacin Decreased side effects [159] Abbreviations: NPs, nanoparticles; MTX, methotrexate; Dex, dexamethasone; SIN, sinomenine hydrochloride; Ket, Ketoprofen; TFC, tofacitinib; PC, piroxicam; FA-AgNPs, folic acid modified with silver nanoparticles; Triam, triamcinolone; CUR, curcumin; Pi, piperine; CIP, ciprofloxacin; RA, rheumatoid arthritis; COX-2, cyclooxygenase 2.…”

Section: Drugs Effects Referencesmentioning

confidence: 99%

Nanomaterials for the Diagnosis and Treatment of Inflammatory Arthritis

Hosseinikhah

Barani

Rahdar

et al. 2021

IJMS

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Nanomaterials have received increasing attention due to their unique chemical and physical properties for the treatment of rheumatoid arthritis (RA), the most common complex multifactorial joint-associated autoimmune inflammatory disorder. RA is characterized by an inflammation of the synovium with increased production of proinflammatory cytokines (IL-1, IL-6, IL-8, and IL-10) and by the destruction of the articular cartilage and bone, and it is associated with the development of cardiovascular disorders such as heart attack and stroke. While a number of imaging tools allow for the monitoring and diagnosis of inflammatory arthritis, and despite ongoing work to enhance their sensitivity and precision, the proper assessment of RA remains difficult particularly in the early stages of the disease. Our goal here is to describe the benefits of applying various nanomaterials as next-generation RA imaging and detection tools using contrast agents and nanosensors and as improved drug delivery systems for the effective treatment of the disease.

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“…Folate receptor can increase macrophage uptake through folate receptor-mediated endocytosis and selectively deliver to the site of inflammation. (Varghese et al, 2014;Mohammadi et al, 2016;Yang et al, 2021) CD64 CD64 is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. There're some advantages for targeting macrophage, such as a strict myeloid cell distribution and the ability to bind and rapidly internalize monomer IgG.…”

Section: Surface Chargementioning

confidence: 99%

Role of macrophage in nanomedicine-based disease treatment

et al. 2021

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Macrophages are a major component of the immunoresponse. Diversity and plasticity are two of the hallmarks of macrophages, which allow them to act as proinflammatory, anti-inflammatory, and homeostatic agents. Research has found that cancer and many inflammatory or autoimmune disorders are correlated with activation and tissue infiltration of macrophages. Recent developments in macrophage nanomedicine-based disease treatment are proving to be timely owing to the increasing inadequacy of traditional treatment. Here, we review the role of macrophages in nanomedicine-based disease treatment. First, we present a brief background on macrophages and nanomedicine. Then, we delve into applications of macrophages as a target for disease treatment and delivery systems and summarize the applications of macrophage-derived extracellular vesicles. Finally, we provide an outlook on the clinical utility of macrophages in nanomedicine-based disease treatment.

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Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization

Cited by 253 publications

References 58 publications

Silver Nanoparticles Stable to Oxidation and Silver Ion Release Show Size-Dependent Toxicity In Vivo

Silver Nanoparticles Stable to Oxidation and Silver Ion Release Show Size-Dependent Toxicity In Vivo

Nanomaterials for the Diagnosis and Treatment of Inflammatory Arthritis

Role of macrophage in nanomedicine-based disease treatment

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