Nanomaterials for the Diagnosis and Treatment of Inflammatory Arthritis

Hosseinikhah, Seyedeh Maryam; Barani, Mahmood; Rahdar, Abbas; Madry, Henning; Arshad, Rabia; Mohammadzadeh, Vahideh; Cucchiarini, Magali

doi:10.3390/ijms22063092

Cited by 33 publications

(17 citation statements)

References 155 publications

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“…Nanomaterials with MR imaging properties have demonstrated promising diagnostic performance in neurodegenerative diseases ( Cui et al, 2021 ). Nanomaterials based on the polydopamine and imaging properties showed great therapeutic potential in inflammation, diabetes, rheumatoid arthritis and neurodegenerative diseases ( Li H. et al, 2021 ; Hosseinikhah et al, 2021 ). And there also had research on imageable nanomaterials in inflammatory and infectious diseases.…”

Section: The Biomedical Applications Of Imageable Nanomaterialsmentioning

confidence: 99%

The Advances and Biomedical Applications of Imageable Nanomaterials

Xiang

Shi²,

Gao³

2022

Front. Bioeng. Biotechnol.

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Nanomedicine shows great potential in screening, diagnosing and treating diseases. However, given the limitations of current technology, detection of some smaller lesions and drugs’ dynamic monitoring still need to be improved. With the advancement of nanotechnology, researchers have produced various nanomaterials with imaging capabilities which have shown great potential in biomedical research. Here, we summarized the researches based on the characteristics of imageable nanomaterials, highlighted the advantages and biomedical applications of imageable nanomaterials in the diagnosis and treatment of diseases, and discussed current challenges and prospects.

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Section: The Biomedical Applications Of Imageable Nanomaterialsmentioning

confidence: 99%

The Advances and Biomedical Applications of Imageable Nanomaterials

Xiang

Shi²,

Gao³

2022

Front. Bioeng. Biotechnol.

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“…Increased targeting ability to arthritis was introduced using MSC-derived EVs and NPs. 184 , 185 MSC membrane-coated NPs are proming strategy for clearing raised concerns from direct use of MSC (with or without NPs) in terms of toxicity, reduced biocompatibility, and poor targeting ability of NPs for the treatment of arthritis.…”

Section: Msc Mimicking Nanoencapsulation Targeting Arthritismentioning

confidence: 99%

Stem Cell Mimicking Nanoencapsulation for Targeting Arthritis

Shin¹,

Park²,

Lee³

et al. 2021

IJN

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Mesenchymal stem cells (MSCs) are considered a promising regenerative therapy due to their ability to migrate toward damaged tissues. The homing ability of MSCs is unique compared with that of non-migrating cells and MSCs are considered promising therapeutic vectors for targeting major cells in many pathophysiological sites. MSCs have many advantages in the treatment of malignant diseases, particularly rheumatoid arthritis (RA). RA is a representative autoimmune disease that primarily affects joints, and secreted chemokines in the joints are well recognized by MSCs following their migration to the joints. Furthermore, MSCs can regulate the inflammatory process and repair damaged cells in the joints. However, the functionality and migration ability of MSCs injected in vivo still show insufficient. The targeting ability and migration efficiency of MSCs can be enhanced by genetic engineering or modification, eg, overexpressing chemokine receptors or migration-related genes, thus maximizing their therapeutic effect. However, there are concerns about genetic changes due to the increased probability of oncogenesis resulting from genome integration of the viral vector, and thus, clinical application is limited. Furthermore, it is suspected that administering MSCs can promote tumor growth and metastasis in xenograft and orthotopic models. For this reason, MSC mimicking nanoencapsulations are an alternative strategy that does not involve using MSCs or bioengineered MSCs. MSC mimicking nanoencapsulations consist of MSC membrane-coated nanoparticles, MSC-derived exosomes and artificial ectosomes, and MSC membrane-fused liposomes with natural or genetically engineered MSC membranes. MSC mimicking nanoencapsulations not only retain the targeting ability of MSCs but also have many advantages in terms of targeted drug delivery. Specifically, MSC mimicking nanoencapsulations are capable of encapsulating drugs with various components, including chemotherapeutic agents, nucleic acids, and proteins. Furthermore, there are fewer concerns over safety issues on MSC mimicking nanoencapsulations associated with mutagenesis even when using genetically engineered MSCs, because MSC mimicking nanoencapsulations use only the membrane fraction of MSCs. Genetic engineering is a promising route in clinical settings, where nano-encapsulated technology strategies are combined. In this review, the mechanism underlying MSC homing and the advantages of MSC mimicking nanoencapsulations are discussed. In addition, genetic engineering of MSCs and MSC mimicking nanoencapsulation is described as a promising strategy for the treatment of immune-related diseases.

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“…Rheumatoid arthritis is a chronic systemic disease with autoimmune pathogenesis and systemic involvement, which is associated with the overexpression profile of many proinflammatory cytokines ( Petrovska et al, 2021 , 102797; Hosseinikhah et al, 2021 ). This autoimmune disorder affects nearly 1% of the total adult population and remains a cause of high rates of morbidity and mortality in humans ( Zhao and Zhang, 2018 , 123).…”

Section: Introductionmentioning

confidence: 99%

Notoginsenoside R1 (NG-R1) Promoted Lymphatic Drainage Function to Ameliorating Rheumatoid Arthritis in TNF-Tg Mice by Suppressing NF-κB Signaling Pathway

et al. 2022

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Rheumatoid arthritis (RA) is a chronic autoimmune disease that is primarily characterized by synovial inflammation. Our previous studies demonstrated that the lymphatic system is critical for the development and maintenance of RA disease, and sufficient lymph drainage helps to improve joint inflammation. In this study, we found that NG-R1, the main active component in the traditional Chinese medicinal herb Sanchi, activating lymphatic function can attenuate synovial inflammation. According to histopathological staining of ankle sections, NG-R1 significantly decreased the area of inflammation and reduced bone destruction of ankle joints in TNF-Tg mice. Near infrared-indocyanine green (NIR-ICG) lymphatic imaging system has shown that NG-R1 significantly improved the lymphatic drainage function. However, the molecular mechanism of its activity is not properly understood. Our in-depth study demonstrates that NG-R1 reduced the inflammatory cytokine production of lymphatic endothelial cells (LECs) stimulated by TNF-α, and the mechanism ameliorated the phosphorylation of IKKα/β and p65, and the translocation of p65 into the nucleus. In summary, this study proved that NG-R1 promoted lymphatic drainage function to ameliorating rheumatoid arthritis in TNF-Tg mice by suppressing NF-κB signaling pathway.

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Nanomaterials for the Diagnosis and Treatment of Inflammatory Arthritis

Cited by 33 publications

References 155 publications

The Advances and Biomedical Applications of Imageable Nanomaterials

The Advances and Biomedical Applications of Imageable Nanomaterials

Stem Cell Mimicking Nanoencapsulation for Targeting Arthritis

Notoginsenoside R1 (NG-R1) Promoted Lymphatic Drainage Function to Ameliorating Rheumatoid Arthritis in TNF-Tg Mice by Suppressing NF-κB Signaling Pathway

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