Targeted near-IR hybrid magnetic nanoparticles for in vivo cancer therapy and imaging

Kirui, Dickson; Khalidov, Ildar; Wang, Yi; Batt, Carl A.

doi:10.1016/j.nano.2012.11.009

Cited by 72 publications

(42 citation statements)

References 41 publications

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“…To investigate the mechanism of in vivo antitumor of HA-Se-PEI@siRNA NP, the tumor tissues were stained by the H&E, 35 and Ki67 36 and the expression of CD31, 37 a marker for neovasculature, were examined. The tumor necrotic fraction is usually identified by H&E staining.…”

Section: In Vivo Anticancer Activitymentioning

confidence: 99%

siRNA-loaded selenium nanoparticle modified with hyaluronic acid for enhanced hepatocellular carcinoma therapy

Xia¹,

Guo²,

Xu³

et al. 2018

IJN

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Background Small interfering RNA (siRNA) as a new therapeutic modality holds promise for cancer treatment. However, the traditional viral carriers are prone to immunogenicity and risk of insertional mutagenesis. Methods In order to provide a tumor-targeted delivery carrier of siRNA in cancer therapy, the hyaluronic acid (HA)-selenium (Se)-polyethylenimine (PEI) nanoparticle (NP) was fabricated by decorating SeNP with HA as a tumor-targeting moiety and by linking the polycationic polymers polyethylenimine PEI onto the surface of SeNP. The siRNA was loaded to the surface of SeNP HA-Se-PEI via the electrostatic interaction between siRNA and PEI to prepare the functionalized SeNP HA-Se-PEI@siRNA. Results The HA-Se-PEI@siRNA was internalized into the HepG2 cell mainly in a clathrin-mediated endocytosis manner. Owing to the active tumor-targeted effect mediated by HA, HA-Se-PEI@siRNA achieved the obvious higher transfection efficiency, greater gene silencing ability, and stronger cytotoxicity in the HepG2 cell compared with the passive tumor-targeted NP Se-PEI@siRNA. The knockdown of hairy and enhancer of split 5 by HA-Se-PEI@siRNA induced the HepG2 cell cycle arrest at the G0/G1 phase and apoptosis. Furthermore, the treatment with HA-Se-PEI@siRNA resulted in greater antitumor efficacy compared with the Se-PEI@siRNA in vitro and in vivo. In addition, the HA-Se-PEI@siRNA was almost no toxic to the key organs of mice. Conclusion These findings provided an alternative therapeutic route for targeted cancer treatments.

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Section: In Vivo Anticancer Activitymentioning

confidence: 99%

siRNA-loaded selenium nanoparticle modified with hyaluronic acid for enhanced hepatocellular carcinoma therapy

Xia¹,

Guo²,

Xu³

et al. 2018

IJN

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“…One of the latest developments in nanomedicine are theranostic particles, which combine imaging or diagnostic and therapeutic features in a single construct 21,22 . Wang et al for example, developed magnetic micelles for gene delivery, enabling the monitoring of the delivery efficiency after administration and Kirui et al created an immunotargeted gold-coated iron oxide NP (IONP) to visualise colorectal tumours by magnetic resonance imaging followed by treatment with hyperthermia 23,24 .…”

Section: Introductionmentioning

confidence: 99%

Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap

et al. 2013

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“…In one such study, gold-iron oxide hybrid NPs were functionalized with A33scFv. 115 This antibody fragment is known to target the A33 antigen, which is expressed by the majority of primary and metastatic colorectal tumors. 116 The A33scFv-targeted NPs were selectively internalized by colorectal SW1222 xenograft tumors over non-A33-expressing cells.…”

Section: Colorectal Cancermentioning

confidence: 99%

Targeted superparamagnetic iron oxide nanoparticles for early detection of cancer: Possibilities and challenges

Bakhtiary

Saei

Hajipour

et al. 2016

Nanomedicine: Nanotechnology, Biology and Medicine

152

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Nanomedicine, the integration of nanotechnological tools in medicine demonstrated promising potential to revolutionize the diagnosis and treatment of various human health conditions. Nanoparticles (NPs) have shown much promise in diagnostics of cancer, especially since they can accommodate targeting molecules on their surface, which search for specific tumor cell receptors upon injection into the blood stream. This concentrates the NPs in the desired tumor location. Furthermore, such receptor-specific targeting may be exploited for detection of potential metastases in an early stage. Some NPs, such as superparamagnetic iron oxide NPs (SPIONs), are also compatible with magnetic resonance imaging (MRI), which makes their clinical translation and application rather easy and accessible for tumor imaging purposes. Furthermore, multifunctional and/or theranostic NPs can be used for simultaneous imaging of cancer and drug delivery. In this review article, we will specifically focus on the application of SPIONs in early detection and imaging of major cancer types.From the Clinical Editor: Super-paramagnetic iron oxide nanoparticles (SPIONs) have been reported by many to be useful as an MRI contrast agent in the detection of tumors. To further enhance the tumor imaging, SPIONs can be coupled with tumor targeting motifs. In this article, the authors performed a comprehensive review on the current status of using targeted SPIONS in tumor detection and also the potential hurdles to overcome. © 2015 Elsevier Inc. All rights reserved. 1 A significant improvement in cancer survival has been noted over the past three decades for most cancer types. This notable and continuous decrement in tumor fatality is related to advanced development in prevention, early diagnosis and therapeutic approaches and decrease in overall prevalence of smoking.1 Early detection of cancer, especially before cancer cells metastasize, is critical for cancer diagnosis, because early stage cancers can be treated more effectively. However, early-stage diagnosis has been difficult to achieve in most cases since clinical symptoms tend to show up at later stages. Therefore, minimally-and non-invasive methods for early detection of cancer are urgently needed in the field. In this regard, many SPION-based systems are under development for more sensitive imaging and earlier detection of tumors. Since non-targeted SPION species cannot readily differentiate cancer tissues from normal tissues, second-generation SPIONs have been developed which are equipped with targeting moieties that can recognize Nanomedicine: Nanotechnology, Biology, and Medicine 12 (2016) 287 -307

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Targeted near-IR hybrid magnetic nanoparticles for in vivo cancer therapy and imaging

Cited by 72 publications

References 41 publications

siRNA-loaded selenium nanoparticle modified with hyaluronic acid for enhanced hepatocellular carcinoma therapy

siRNA-loaded selenium nanoparticle modified with hyaluronic acid for enhanced hepatocellular carcinoma therapy

Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap

Targeted superparamagnetic iron oxide nanoparticles for early detection of cancer: Possibilities and challenges

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