Targeted isolation of terpenoid indole alkaloids from Melodinus cochinchinensis (Lour.) Merr. using molecular networking and their biological activities

Li, Fang-Ru; Wang, Yudan; He, Shuyue; Khan, Afsar; Xue, Qingwang; Cui, Qi-Min; Liu, Lu; Liu, Yaping; Cheng, Guiguang

doi:10.1016/j.indcrop.2020.112922

Cited by 21 publications

(7 citation statements)

References 45 publications

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“…The details of the conditions and parameters of mass spectrometry were the same as those previously described. 18…”

Section: Methodsmentioning

confidence: 99%

“…The details of the conditions and parameters of mass spectrometry were the same as those previously described. 18 For qualitative and quantitative analyses, the chemical profiles and mass data were analyzed using Xcalibur software. The contents of the phenolic and flavonoid compounds were quantified by external standard calibration curves, which had good linearities and R 2 values greater than 0.99, based on peak areas at different concentrations.…”

Section: Qualitative and Quantitative Analyses Of Phenolics And Flavo...mentioning

confidence: 99%

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E Se tea alleviates acetaminophen-induced liver injury by activating the Nrf2 signaling pathway

Zhang

Zhao

et al. 2022

Food Funct.

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“…The details of the conditions and parameters of mass spectrometry were the same as those previously described. 18…”

Section: Methodsmentioning

confidence: 99%

Section: Qualitative and Quantitative Analyses Of Phenolics And Flavo...mentioning

confidence: 99%

E Se tea alleviates acetaminophen-induced liver injury by activating the Nrf2 signaling pathway

Zhang

Zhao

et al. 2022

Food Funct.

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“…A gradient program was adapted as follows: 0-30 min, 10-60% B; 30-35 min, 100% B. The flow rate was 0.2 mL/min, the injection volume was 2 µL, and the column temperature was maintained at 35 • C. The HR-ESI-MS/MS data were analyzed on a Q-Exactive Orbitrap mass spectrometer (Thermo Fisher Scientific, Germany) as per our previously reported condition [45]. The specific parameters performed: resolution, 70,000; auxiliary gas flow, 8 L/min; sheath gas flow rate, 32 L/min; sweep gas, 4 L/min; S-lens RF level, 50%; spray voltage, 3.3 kV, capillary temperature, 320 • C; and heater temperature, 350 • C. The ions were scanned in negative mode with a mass range from m/z 50 to 1000.…”

Section: Characterization and Quantification Of Isolated Compounds Inmentioning

confidence: 99%

Bioactivity-Guided Isolation of Phytochemicals from Vaccinium dunalianum Wight and Their Antioxidant and Enzyme Inhibitory Activities

et al. 2021

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Vaccinium dunalianum Wight, usually processed as a traditional folk tea beverage, is widely distributed in the southwest of China. The present study aimed to investigate the antioxidant, α-glucosidase and pancreatic lipase inhibitory activities of V.dunalianum extract and isolate the bioactive components. In this study, the crude extract (CE) from the buds of V. dunalianum was prepared by the ultrasound-assisted extraction method in 70% methanol and then purified with macroporous resin D101 to obtain the purified extract (PM). Five fractions (Fr. A–E) were further obtained by MPLC column (RP-C18). Bioactivity assays revealed that Fr. B with 40% methanol and Fr. D with 80% methanol had better antioxidant with 0.48 ± 0.03 and 0.62 ± 0.01 nM Trolox equivalent (TE)/mg extract for DPPH, 0.87 ± 0.02 and 1.58 ± 0.02 nM TE/mg extract for FRAP, 14.42 ± 0.41 and 19.25 ± 0.23 nM TE/mg extract for ABTS, and enzyme inhibitory effects with IC50 values of 95.21 ± 2.21 and 74.55 ± 3.85 for α-glucosidase, and 142.53 ± 11.45 and 128.76 ± 13.85 µg/mL for pancreatic lipase. Multivariate analysis indicated that the TPC and TFC were positively related to the antioxidant activities. Further phytochemical purification led to the isolation of ten compounds (1–10). 6-O-Caffeoylarbutin (7) showed significant inhibitory effects on α-glucosidase and pancreatic lipase enzymes with values of 38.38 ± 1.84 and 97.56 ± 7.53 µg/mL, and had the highest antioxidant capacity compared to the other compounds.

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“…Previous studies reported that P. wallichiana is rich in phytochemicals, including carbohydrates, polyphenols, flavonoids, terpenes, etc. [ 9 , 10 ], which are reported to have anti-inflammatory and antioxidant effects [ 11 , 12 , 13 ]. However, whether P. wallichiana consumed as food has therapeutic effects on intestinal diseases has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Ethanolic Extract from Pteris wallichiana Alleviates DSS-Induced Intestinal Inflammation and Intestinal Barrier Dysfunction by Inhibiting the TLR4/NF-κB Pathway and Regulating Tight Junction Proteins

et al. 2022

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The aim of the research was to determine the protective effect and mechanism of Pteris wallichiana J. Agardh extract (PWE) on DSS-induced ulcerative colitis (UC) in mice. In this research, PWE is rich in flavonoids and diterpenoids by UPLC-MS/MS analysis. In LPS-induced RAW264.7 cells, PWE reduced the productions of inflammatory factors (i.e., NO, TNF-α, IL-6, and IL-1β). In DSS-induced UC in mice, PWE improved disease activity index (DAI) score, attenuated oxidative stress by decreasing MPO and MDA activities and activating GSH and SOD levels, and inhibited TNF-α, IL-6, and IL-1β expressions in the colonic tissues. PWE also improved the intestinal barrier by upregulating the expressions of tight junction proteins, including occludin and ZO-1. Moreover, PWE extract alleviated intestinal inflammation by suppressing the TLR4/MyD88/NF-κB signaling pathway. Conclusion: PWE can alleviate DSS-induced UC in mice by increasing the expressions of intestinal tight junction proteins and inhibiting the TLR4/NF-κB inflammatory pathway.

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Targeted isolation of terpenoid indole alkaloids from Melodinus cochinchinensis (Lour.) Merr. using molecular networking and their biological activities

Cited by 21 publications

References 45 publications

E Se tea alleviates acetaminophen-induced liver injury by activating the Nrf2 signaling pathway

E Se tea alleviates acetaminophen-induced liver injury by activating the Nrf2 signaling pathway

Bioactivity-Guided Isolation of Phytochemicals from Vaccinium dunalianum Wight and Their Antioxidant and Enzyme Inhibitory Activities

Ethanolic Extract from Pteris wallichiana Alleviates DSS-Induced Intestinal Inflammation and Intestinal Barrier Dysfunction by Inhibiting the TLR4/NF-κB Pathway and Regulating Tight Junction Proteins

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