Targeted drug-delivery approaches by nanoparticulate carriers in the therapy of inflammatory diseases

Abstract

Limitations in therapy induced by adverse effects due to unselective drug availability and therefore the use of potentially too high doses are a common problem. One prominent example for this dilemma are inflammatory diseases. Colloidal carriers allow one to improve delivery of drugs to the site of action and appear promising to overcome this general therapeutic drawback. Specific uptake of nanoparticles by immune-related cells in inflamed barriers offers selective drug targeting to the inflamed tissue. Here we focus on nanocarrier-based drug delivery strategies for the treatment of common inflammatory disorders like rheumatoid arthritis, multiple sclerosis, uveitis or inflammatory bowel disease.

"CHARACTERISTICS AND MAGNETIC PROPERTIES OF CHITOSAN-COATED Fe3O4 NANOPARTICLES PREPARED BY EX-SITU CO-PRECIPITATION METHOD"

“…1,2 Materials for drug delivery applications can be produced from nanoparticles. Nanoparticles have promising potential for use in various applications due to their unusual characteristics compared to their bulk materials.…”

Oxaprozin-Loaded Lipid Nanoparticles towards Overcoming NSAIDs Side-Effects

“…This type of targeting can be achieved without the incorporation of specific targeting moieties on the drug system surface [76].…”

“…So this will, consequently, increase drug concentration in the site of action and improve the selectivity of the delivery systems. Targeting systems can be classified as passive and active [76].…”

Liposomes in tissue engineering and regenerative medicine

“…Since their discovery, a large number of studies have been carried out to understand their biophysical and biochemical properties, and possible applications. They have been used as: model membrane systems to study the basic nature of cell membranes [6], in biochemistry and molecular biology [6,18], in analytical methods [18], in microfluidic technologies [19], as a template for the production of nanogels [20], in cosmetics and food technology [21,22], in imaging [23], as drug delivery systems in pharmacology [24][25][26], and in TE [27]. In this section, we will revisit the liposome properties, their formulation/functionalization, preparation methods and stability.…”