Results suggest an enhanced cellular uptake of conjugated liposomes, mainly mediated by caveolae- and clathrin-dependent endocytosis. In vitro release studies demonstrated that prednisolone was preferentially released under acidic conditions mimicking intracellular endosomal compartments. Overall, results revealed that conjugated pH-sensitive liposomes are a promising nanoapproach for the targeted delivery of prednisolone within inflamed synovial cells for rheumatoid arthritis treatment.
The inflammatory process is the innate immune response for the presence of pathogens, toxic molecules, tissue injuries or any other harmful conditions. The inflammation process is characterized for redness, pain, swelling, heat and disturbance of function and comprises inducers, sensors, mediators and effectors components from cellular and humoral origin.
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