Targeted dose enhancement in radiotherapy for breast cancer using gold nanoparticles, part 1: A radiobiological model study

Ferrero, Veronica; Visoná, Giovanni; Dalmasso, F; Gobbato, A.; Cerello, Piergiorgio; Strigari, Lidia; Visentin, Sonja; Attili, A.

doi:10.1002/mp.12180

Cited by 25 publications

(31 citation statements)

References 50 publications

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“…A simplified analytical expression of the LEM model has been introduced and verified using experimental data in a separate paper. 9 Through our model, GNP radiosensitization can be evaluated with a few parameters (i.e., the LQ control parameters, the ionization rate per GNP per Gy and the number of GNPs). As opposed to the models proposed previously, 32,33 the detailed knowledge of the photon spectrum and the GNP ionization profiles are not fundamental.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, the value of N 0 ion on the voxel v relative to the entrance of the patient was also adopted for all the voxels evaluated in the treatment plans. 9 These parameters are expected to vary within 10% in the depth range from 0 up to 20 cm (i.e., the maximum depth found in the breast treatments investigated in this paper), due to the photon spectrum variation at different depths (see for example 19 ). However, this variation is expected to be lower when multiple fields are used, as in our study.…”

Section: C1 Tcp Calculationmentioning

confidence: 90%

“…The explicit expression of the LQ parameters for the net cell survival in presence the of gold nanoparticles in the framework of the LEM was derived from a separate paper 9 and is reported in the following equations:…”

Section: C1 Tcp Calculationmentioning

confidence: 99%

“…where N 0 ion is the expected number of ionizations per Gy in water per nanoparticle that depends on the GNP size and the photon energy spectrum found in the voxel v. N 0 ion , evaluated using Monte Carlo simulation as described previously, 9 was equal to 2:35 Â 10 À7 and 2:25 Â 10 À7 per Gy per GNP for 6 and 15 MV, respectively.…”

Section: C1 Tcp Calculationmentioning

confidence: 99%

“…Through the explicit LQ formulae in Eq. 6 a relatively simple expression of the voxel-dependent RBE can be derived: 9,18 where R ¼ a c =b c , and…”

Section: C1 Tcp Calculationmentioning

confidence: 99%

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Targeted dose enhancement in radiotherapy for breast cancer using gold nanoparticles, part 2: A treatment planning study

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Section: C1 Tcp Calculationmentioning

confidence: 90%

Section: C1 Tcp Calculationmentioning

confidence: 99%

Section: C1 Tcp Calculationmentioning

confidence: 99%

“…Through the explicit LQ formulae in Eq. 6 a relatively simple expression of the voxel-dependent RBE can be derived: 9,18 where R ¼ a c =b c , and…”

Section: C1 Tcp Calculationmentioning

confidence: 99%

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Targeted dose enhancement in radiotherapy for breast cancer using gold nanoparticles, part 2: A treatment planning study

et al. 2017

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Gold Nanoparticles in Radiotherapy and Recent Progress in Nanobrachytherapy

Laprise-Pelletier

Simão

Fortin

2018

Adv Healthcare Materials

110

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Over the last few decades, gold nanoparticles (GNPs) have emerged as "radiosensitizers" in oncology. Radiosensitizers are additives that can enhance the effects of radiation on biological tissues treated with radiotherapy. The interaction of photons with GNPs leads to the emission of low-energy and short-range secondary electrons, which in turn increase the dose deposited in tissues. In this context, GNPs are the subject of intensive theoretical and experimental studies aiming at optimizing the parameters leading to greater dose enhancement and highest therapeutic effect. This review describes the main mechanisms occurring between photons and GNPs that lead to dose enhancement. The outcome of theoretical simulations of the interactions between GNPs and photons is presented. Finally, the findings of the most recent in vivo studies about interactions between GNPs and photon sources (e.g., external beams, brachytherapy sources, and molecules labeled with radioisotopes) are described. The advantages and challenges inherent to each of these approaches are discussed. Future directions, providing new guidelines for the successful translation of GNPs into clinical applications, are also highlighted.

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Mechanisms of nanoparticle radiosensitization

Kempson

2020

WIREs Nanomed Nanobiotechnol

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Metal‐based nanoparticles applied to potentiating the effects of radiotherapy have drawn significant attention from the research community and are now available clinically. By improving our mechanistic understanding, nanoparticles are likely to evolve to provide very significant improvements in radiotherapy outcomes with only incremental increase in cost. This review critically assesses the inconsistent observations surrounding physical, physicochemical, chemical and biological mechanisms of radiosensitization. In doing so, a number of needs are identified for continuing research and are highlighted. The large degree of variability from one nanoparticle to another emphasizes that it is a mistake to generalize nanoparticle radiosensitizer mechanisms. Nanoparticle formulations should be considered in an analogous way as pharmacological agents and as a broad class of therapeutic agents, needing to be considered with a high degree of individuality with respect to their interactions and ultimate impact on radiobiological response. In the same way that no universal anti‐cancer drug exists, it is unlikely that a single nanoparticle formulation will lead to the best therapeutic outcomes for all cancers. The high degree of complexity and variability in mechanistic action provides notable opportunities for nanoparticle formulations to be optimized for specific indications. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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Targeted dose enhancement in radiotherapy for breast cancer using gold nanoparticles, part 1: A radiobiological model study

Cited by 25 publications

References 50 publications

Targeted dose enhancement in radiotherapy for breast cancer using gold nanoparticles, part 2: A treatment planning study

Targeted dose enhancement in radiotherapy for breast cancer using gold nanoparticles, part 2: A treatment planning study

Gold Nanoparticles in Radiotherapy and Recent Progress in Nanobrachytherapy

Mechanisms of nanoparticle radiosensitization

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