Targeted dose enhancement in radiotherapy for breast cancer using gold nanoparticles, part 2: A treatment planning study

Abstract

The model provides a useful framework to estimate the nanoparticle-driven radiosensitivity in breast cancer treatment irradiation, accounting for the complex interplay between dose and GNP uptake distributions.

Exploring gold nanoparticles interaction with mucins: A spectroscopic-based study

“…The main application could be their use in cancer diagnosis and therapies (Mesbahi and Carlo, 2010). In fact, it was demonstrated that GNPs contribute to enhance the generation of reactive oxygen species (ROS) such as ꞏOH, O 2and 1 O2, under irradiation of X-rays in the diagnostic range (Ferrero et al, 2017;Strigari et al, 2017).…”

Targeted dose enhancement in radiotherapy for breast cancer using gold nanoparticles, part 1: A radiobiological model study

“…The model provides a useful framework to estimate the nanoparticle-driven radiosensitivity in treatment irradiations and could be applied to clinical treatment plan simulations as reported in the second part of the paper. 22…”

“…Higher biological effects resulted at kV energies, which is in accordance with the higher gold cross-section, and are lower for 6 and 15 MV irradiations, which were used in the treatment simulations in the second part of this work. 22 The RBE produced by any concentration of GNPs can be evaluated according to the analytical formulation by Eqs. (15) and (17).…”

“…This gives the LEM-AM analytical formulation a flexibility that can be exploited in more complex evaluations, such as treatment simulations as reported in the second part of this work. 22 In the case of a nominal concentration of 12 lm, independent measurements made using emission spectroscopy and imaged intracellular localization by transmission electron microscopy, report an experimental value of the number of nanoparticles found in the cell to be 1:3 Â 10 8 . 23 This value is higher than the one found by fitting the model over survival data (5 Â 10 5 ).…”

“…The quantitation of impact on the therapeutic index of radiotherapy combined with GNPs in selected breast cancer patients using realistic treatments is reported in the second part of the present work. 22…”