“…Recently, a loss of virulence has been reported when FAAL-like domain (FLD)-containing protein, CPS1, a DIP2 orthologue, is mutated in either plant pathogenic fungi, which causes rice blast and wheat head scab, or human pathogenic fungus, that cause valley fever ( Lu et al, 2003 ; Narra et al, 2016 ; Wang et al, 2016 ). Furthermore, DIP2 has been shown to be crucial for axonal branching, neurite sprouting, and dendritic spine morphogenesis in Drosophila , Caenorhabditis elegans , and mice, respectively ( Ma et al, 2019a ; Ma et al, 2019b ; Sah et al, 2020 ; Ma et al, 2019a ; Nitta et al, 2017 ; Noblett et al, 2019 ; Xing et al, 2020 ). Three paralogues of DIP2 in humans have been implicated as a potential risk factor for neurodevelopmental disorders like autism spectrum disorders (ASDs) and other diseases ( Egger et al, 2014 ; Gong et al, 2018 ; Iossifov et al, 2012 ; Jiao et al, 2012 ; Kong et al, 2016 ; Poelmans et al, 2009 ; Rudin et al, 2012 ; Larsson et al, 2017 ; Supplementary file 1 ).…”