Targeted Delivery of Transferrin-Conjugated Liposomes to an Orthotopic Model of Lung Cancer in Nude Rats

Abstract

Drug targeting demonstrated potential for improving the aerosol treatment of lung cancer.

Targeted delivery of chemically modified anti-miR-221 to hepatocellular carcinoma with negatively charged liposomes

“…DSPEmPEG 2000 -NH 2 has been used as a linker for conjugating Tf. [38][39][40] Using the passive entrapment procedure and thin-film dispersion method, CHOL-anti-miR-221 was encapsulated at an efficiency of 70% which is much higher than that of anti-miR-221 without CHOL modification (20%). In the preparation, Tf-RL had an average particle size of 122 nm with a narrow size distribution (low polydispersity index values).…”

Liposome as nanocarrier: Site targeted delivery in lung cancer

“…Gaspar et al [94] studied that a valuable remedy is attained by combining the gasp treatment and drug targeting methods (Tf)-conjugated PEG liposomes encumbered with DOX were given by intracorporeal nebulizing tube to lung cancer of rat model [95]. Various DOX products and dosage (0.2 and 0.4 mg/kg) were experienced for their effect on cancer progression.…”

“…Rats' life time was compared to administration of Tf-PEG-liposomes encapsulating DOX (2 mg/kg). Gaspar et al [94] concluded that control group rats showed the incredible weight decrease 2 weeks after tumor initiation and died in days 19 and 29. Animal lungs showed diverse foci of neoplastic insertions, up to 20 mm in place of the intact lobe.…”

“…No important infringement in survival was seen among the treated animals with free drug aerosols, Tf-modified liposomes and DOX encapsulated in a plain. The basic principle of study was to scrutinize if the active drug destined through Tf receptor-mediated uptake, can additionally recover the curative proficiency of localized cure of lung cancer [94].…”

Transferrin conjugation does not increase the efficiency of liposomal Foscan during in vitro photodynamic therapy of oesophageal cancer

“…The conjugation of Tf to liposomes was achieved using a previously published method of EDC and S-NHS-mediated amide bond formation between the carboxyl groups of DSPE-PEG-COOH and free amine groups of the transferrin molecule (Gaspar et al, 2012). Briefly, to 1 ml of liposomes (lipid concentration: 10 µmol/ml), 1 ml of PBS, 180 μl of S-NHS and 180 μl of EDC, both freshly prepared 0.25 M in PBS, were added.…”