Targeted Delivery of miRNA-204-5p By PEGylated Polymer Nanoparticles for Colon Cancer Therapy

Zheng, Bo; Chen, Lu; Pan, Chun-Chun; Wang, Jianzhang; Lu, Guangrong; Yang, Shou‐Xing; Xue, Zhanxiong; Wang, Fangyan; Xu, Chunyan

doi:10.2217/nnm-2017-0345

Cited by 42 publications

(25 citation statements)

References 42 publications

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“…Our and other studies have demonstrated that miR-204-5p could increase the sensitivity of tumor cells to chemotherapeutic drugs. 8,9,23,24 In this study, our in vitro assays confirmed that exosomal miR-204-5p could efficiently enhance the cytotoxicity of 5-FU by increasing 5-FU-induced apoptosis. Liu et al showed that engineered tumor-targeting hEVs are promising natural vectors to overcome MDR.…”

Section: F I G U R Esupporting

confidence: 70%

Exosome‐mediated delivery of miR‐204‐5p inhibits tumor growth and chemoresistance

et al. 2020

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Section: F I G U R Esupporting

confidence: 70%

Exosome‐mediated delivery of miR‐204‐5p inhibits tumor growth and chemoresistance

et al. 2020

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“…A recent work evaluated an oral delivery system intended for treatment of colon cancer by encapsulating hSET1 antisense and SN38 anticancer in nanoparticles with results effective against HT29 cells. Also, more recently it was proposed against CRC to encapsulate miR-204-5p with poly ( d , l -lactide- co -glycolide)/poly ( l -lactide)-block-poly (ethylene glycol)-folate polymer to promote apoptosis and inhibit cell proliferation in an in vitro xenograft model with Luc-HT-29 [85–87]. Although it is a very promising area in the treatment against cancer, it still requires further evaluation of the role of different vectors to find the most suitable and safe, efficient and without long-term toxicity for its application in humans.…”

Section: Therapeutic Strategymentioning

confidence: 99%

Effects of pericytes and colon cancer stem cells in the tumor microenvironment

et al. 2019

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Colorectal cancer (CRC) is one type of tumor with the highest frequency and mortality worldwide. Although current treatments increase patient survival, it is important to detect CRC in early stages; however, most CRC, despite responding favorably to treatment, develop resistance and present recurrence, a situation that will inevitably lead to death. In recent years, it has been shown that the main reason for drug resistance is the presence of colon cancer stem cells (CSC). Pericytes are also capable of tumor homing and are important cellular components of the tumor microenvironment (TME), contributing to the formation of vessels and promoting metastasis; however, they have not been considered very important as a therapeutic target in cancer. In this review, we highlight the contribution of pericytes and cancer stem cells to some classical hallmarks of cancer, namely, tumor angiogenesis, growth, metastasis, and evasion of immune destruction, and discuss therapies targeting pericytes and cancer stem cells in CRC.

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“…In some cases, this leads to RNA loading within the PLGA NP core, while in others the RNA is bound to the exterior of the PLGA NP . In an alternative approach, copolymers of PEI‐PLGA, PLL‐PLGA, or PLA‐PLGA can be used to synthesize miRNA‐loaded NPs. With these various formulations, encapsulation efficiencies ranging from 78.3% up to 95.1% have been reported.…”

Section: Polymer Nanocarriers For Mirna Deliverymentioning

confidence: 99%

“…Excitingly, several other PLGA NP miRNA nanocarriers have achieved in vivo success. For example, PLGA NPs have been used to treat multiple myeloma via miR‐34a delivery, hepatic carcinoma via miR‐99a delivery, and colon cancer via miR‐204 delivery in murine models. These studies demonstrate the substantial potential of PLGA NPs as miRNA delivery vehicles.…”

Section: Polymer Nanocarriers For Mirna Deliverymentioning

confidence: 99%

Polymer nanocarriers for MicroRNA delivery

Kapadia

Luo

Dang

et al. 2019

J of Applied Polymer Sci

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Abnormal expression of microRNAs (miRNAs), which are highlyconserved noncoding RNAs that regulate the expression of various genes post transcriptionally to control cellular functions, has been associated with the development of many diseases. In some cases, disease‐promoting miRNAs are upregulated, while in other instances disease‐suppressive miRNAs are downregulated. To alleviate this imbalanced miRNA expression, either antagomiRs or miRNA mimics can be delivered to cells to inhibit or promote miRNA expression, respectively. Unfortunately, the clinical translation of bare antagomiRs and miRNA mimics has been challenging because nucleic acids are susceptible to nuclease degradation, display unfavorable pharmacokinetics, and cannot passively enter cells. This review emphasizes the challenges associated with miRNA mimic delivery and then discusses the design and implementation of polymer nanocarriers to overcome these challenges. Preclinical efforts are summarized, and a forward‐looking perspective on the future clinical translation of polymer nanomaterials as miRNA delivery vehicles is provided. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48651.

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Targeted Delivery of miRNA-204-5p By PEGylated Polymer Nanoparticles for Colon Cancer Therapy

Abstract: Our study demonstrates a convenient miRNA delivery system that targets tumor tissue and exerts tumor suppressive function, thus demonstrating a potential new therapeutic option for colon cancer.

Cited by 42 publications

References 42 publications

Exosome‐mediated delivery of miR‐204‐5p inhibits tumor growth and chemoresistance

Exosome‐mediated delivery of miR‐204‐5p inhibits tumor growth and chemoresistance

Effects of pericytes and colon cancer stem cells in the tumor microenvironment

Polymer nanocarriers for MicroRNA delivery

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