Polymer nanocarriers for MicroRNA delivery

Kapadia, Chintan H.; Luo, Benjamin; Dang, Megan N.; Irvin-Choy, N'Dea; Valcourt, Danielle M.; Day, Emily S.

doi:10.1002/app.48651

Cited by 34 publications

(25 citation statements)

References 170 publications

(305 reference statements)

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“…Polymer nanoplatforms are popular materials for RNA delivery due to their great diversity, structural flexibility, and low immunogenicity. [ 128 , 129 , 130 ] Many studies have adopted new strategies to engineer a new class of synthesized polymers or copolymers with lower toxicity, higher transfection efficiency, and stability. This endeavor involves chemical modification of traditional polymers used to form polyplexes and studying large polymeric libraries through the implementation of high‐throughput strategies, which ease the assessment of the relationship between structure and activity.…”

Section: Nanocarriersmentioning

confidence: 99%

Nanotechnology‐Assisted RNA Delivery: From Nucleic Acid Therapeutics to COVID‐19 Vaccines

et al. 2021

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In recent years, the main quest of science has been the pioneering of the groundbreaking biomedical strategies needed for achieving a personalized medicine. Ribonucleic acids (RNAs) are outstanding bioactive macromolecules identified as pivotal actors in regulating a wide range of biochemical pathways. The ability to intimately control the cell fate and tissue activities makes RNA‐based drugs the most fascinating family of bioactive agents. However, achieving a widespread application of RNA therapeutics in humans is still a challenging feat, due to both the instability of naked RNA and the presence of biological barriers aimed at hindering the entrance of RNA into cells. Recently, material scientists’ enormous efforts have led to the development of various classes of nanostructured carriers customized to overcome these limitations. This work systematically reviews the current advances in developing the next generation of drugs based on nanotechnology‐assisted RNA delivery. The features of the most used RNA molecules are presented, together with the development strategies and properties of nanostructured vehicles. Also provided is an in‐depth overview of various therapeutic applications of the presented systems, including coronavirus disease vaccines and the newest trends in the field. Lastly, emerging challenges and future perspectives for nanotechnology‐mediated RNA therapies are discussed.

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Section: Nanocarriersmentioning

confidence: 99%

Nanotechnology‐Assisted RNA Delivery: From Nucleic Acid Therapeutics to COVID‐19 Vaccines

et al. 2021

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“…Three main types of polymeric nanocarriers have been studied for miRNA delivery and are represented by polyplexes, polylactic-co-glycolic acid (PLGA) NPs and dendrimers (Table 3). The miRNA can be incorporated to the delivery systems by complexation (electrostatic interactions), conjugation (covalent linkers), or encapsulation [18,85].…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

miRNA Delivery by Nanosystems: State of the Art and Perspectives

et al. 2021

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MicroRNAs (miRNAs) are short (~21–23 nucleotides), non-coding endogenous RNA molecules that modulate gene expression at the post-transcriptional level via the endogenous RNA interference machinery of the cell. They have emerged as potential biopharmaceuticals candidates for the treatment of various diseases, including cancer, cardiovascular and metabolic diseases. However, in order to advance miRNAs therapeutics into clinical settings, their delivery remains a major challenge. Different types of vectors have been investigated to allow the delivery of miRNA in the diseased tissue. In particular, non-viral delivery systems have shown important advantages such as versatility, low cost, easy fabrication and low immunogenicity. Here, we present a general overview of the main types of non-viral vectors developed for miRNA delivery, with their advantages, limitations and future perspectives.

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“…They may arise from natural or synthetic origins, be charged or neutral, or hydrophobic or hydrophilic. [ 89 ] There is a wide array of materials to select from and herein we highlight the most commonly used polymeric carriers used for the delivery of anti‐cancer RNA based medicines in recent years ( Table 2 ).…”

Section: Rnai Therapeutic Delivery Systemsmentioning

confidence: 99%

Innovations in Biomaterial Design toward Successful RNA Interference Therapy for Cancer Treatment

Ward

Shodeinde

Peppas

2021

Adv Healthcare Materials

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Gene regulation using RNA interference (RNAi) therapy has been developed as one of the frontiers in cancer treatment. The ability to tailor the expression of genes by delivering synthetic oligonucleotides to tumor cells has transformed the way scientists think about treating cancer. However, its clinical application has been limited due to the need to deliver synthetic RNAi oligonucleotides efficiently and effectively to target cells. Advances in nanotechnology and biomaterials have begun to address the limitations to RNAi therapeutic delivery, increasing the likelihood of RNAi therapeutics for cancer treatment in clinical settings. Herein, innovations in the design of nanocarriers for the delivery of oligonucleotides for successful RNAi therapy are discussed.

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Polymer nanocarriers for MicroRNA delivery

Cited by 34 publications

References 170 publications

Nanotechnology‐Assisted RNA Delivery: From Nucleic Acid Therapeutics to COVID‐19 Vaccines

Nanotechnology‐Assisted RNA Delivery: From Nucleic Acid Therapeutics to COVID‐19 Vaccines

miRNA Delivery by Nanosystems: State of the Art and Perspectives

Innovations in Biomaterial Design toward Successful RNA Interference Therapy for Cancer Treatment

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