Targeted Delivery of DNA‐Au Nanoparticles across the Blood–Brain Barrier Using Focused Ultrasound

Chan, Tiffany G.; Morse, Sophie V.; Copping, Matthew J.; Choi, James J.; Vilar, Ramón

doi:10.1002/cmdc.201800262

Cited by 28 publications

(22 citation statements)

References 27 publications

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“…In biological systems, AuNPs are considered stable and non-immunogenic (Shukla et al, 2005). Therapeutically, one of the most promising avenues for the use of AuNP is the treatment of brain cancer (Raliya et al, 2017;Chan et al, 2018;Coluccia et al, 2018).…”

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confidence: 99%

Organotypic and primary neural cultures as models to assess effects of different gold nanostructures on glia and neurons

Moquin

Bertorelle

et al. 2019

Nanotoxicology

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Gold nanoparticles (AuNP) have unique physicochemical properties and have been used as delivery vehicles, contrast agents, and therapeutic compounds. Although the effects of AuNPs on peripheral tissues and immortalized cell lines have been extensively characterized, their effects on the central nervous system (CNS) are predominantly unknown. The main objective of the current study was to evaluate how AuNPs of varying sizes (1-100 nm), shapes (clusters, spheres, rods, flowers), and surfaces impact synaptic structures in the hippocampus, a brain structure often affected in neurodegeneration. Using a combination of organotypic hippocampal, as well as, primary neuronal, glial, and astrocytic cultures, we examined AuNPs impact on hippocampal dendritic spine density, internalization in various neural cells, and the status of the lysosome. Results from these studies show that AuNPs with poly(ethylene glycol) surfaces (AuNPs-PEG) do not substantially decrease hippocampal dendritic spine density. Conversely, AuNPs coated with the detergent, CTAB, significantly

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confidence: 99%

Organotypic and primary neural cultures as models to assess effects of different gold nanostructures on glia and neurons

Moquin

Bertorelle

et al. 2019

Nanotoxicology

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“…For instance, Chan and colleagues firstly coated Au-NPs with a layer of DNA comprising constructed sequences. Using the carrier complex of DNA-coated Au-NPs, they generated immobilizing target DNA or siRNA of interest, providing effective DDSs for BC treatment [74].…”

Section: Neutral/charged Drugsmentioning

confidence: 99%

Targeting Engineered Nanoparticles for Breast Cancer Therapy

et al. 2021

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Breast cancer (BC) is the second most common cancer in women globally after lung cancer. Presently, the most important approach for BC treatment consists of surgery, followed by radiotherapy and chemotherapy. The latter therapeutic methods are often unsuccessful in the treatment of BC because of their various side effects and the damage incurred to healthy tissues and organs. Currently, numerous nanoparticles (NPs) have been identified and synthesized to selectively target BC cells without causing any impairments to the adjacent normal tissues or organs. Based on an exploratory study, this comprehensive review aims to provide information on engineered NPs and their payloads as promising tools in the treatment of BC. Therapeutic drugs or natural bioactive compounds generally incorporate engineered NPs of ideal sizes and shapes to enhance their solubility, circulatory half-life, and biodistribution, while reducing their side effects and immunogenicity. Furthermore, ligands such as peptides, antibodies, and nucleic acids on the surface of NPs precisely target BC cells. Studies on the synthesis of engineered NPs and their impact on BC were obtained from PubMed, Science Direct, and Google Scholar. This review provides insights on the importance of engineered NPs and their methodology for validation as a next-generation platform with preventive and therapeutic effects against BC.

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“…However, the 31 The AuNPs were synthesized following previously reported procedures. 29 Briefly, they were grown through the reduction of HAuCl4 with sodium citrate and tannic acid to yield quasi- The changes observed in the hydrodynamic diameter (dh) and zeta potential (ζ) of the NPs after functionalization (see Table S3) suggest that all three methods yield AuNPs passivated with both the oligonucleotides and receptor-drug conjugate 6. However, a higher oligonucleotide loadingwhich, in turn, increases the stability and biocompatibility of the S3 in the ESI).…”

Section: Synthesis Of Complexes 3 Andmentioning

confidence: 99%

Molecular recognition of bisphosphonate-based drugs by di-zinc receptors in aqueous solution and on gold nanoparticles

et al. 2020

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Targeted Delivery of DNA‐Au Nanoparticles across the Blood–Brain Barrier Using Focused Ultrasound

Cited by 28 publications

References 27 publications

Organotypic and primary neural cultures as models to assess effects of different gold nanostructures on glia and neurons

Organotypic and primary neural cultures as models to assess effects of different gold nanostructures on glia and neurons

Targeting Engineered Nanoparticles for Breast Cancer Therapy

Molecular recognition of bisphosphonate-based drugs by di-zinc receptors in aqueous solution and on gold nanoparticles

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