Targeted damage effects of high intensity focused ultrasound (HIFU) on liver tissues of Guizhou province miniswine

Wang, Zhi B.; Wu, Feng; Wang, Zhi L.; Zhang, Zhe; Zou, Jian Zhong; Liu, Chuan; Liu, Yu G.; Xun, Cheng; Du, Yong; He, Zheng C.; Gu, Mei L.; Wang, Zhi G.; Feng, Ruo

doi:10.1016/s1350-4177(97)00028-x

Cited by 42 publications

(15 citation statements)

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“…HIFU can pass through tissues and accurately damage target tissues inside organisms. The boundary between therapy zone and un-therapy zone is clear, tissue beyond target zone is hardly destroyed or without damage [16,17] . Ultrasound Therapy Section of London Emperor Hospital, Britain found that only six cells existed between cells killed completely and cells without damage [18] .…”

Section: Discussionmentioning

confidence: 99%

Analysis of clinical effect of high-intensity focused ultrasound on liver cancer

Li¹,

Xu²,

Jiang³

et al. 2004

WJG

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AIM:To evaluate the clinical effect of high-intensity focused ultrasound (HIFU) in the treatment of patients with liver cancer.METHODS: HIFU treatment was performed in 100 patients with liver cancer under general anesthesia and by a targeted ultrasound. Evaluation of efficacy was made on the basis of clinical symptoms, liver function tests, AFP, MRI or CT before and after the treatment. RESULTS:After HIFU treatment, clinical symptoms were relieved in 86.6%(71/82) of patients. The ascites disappeared in 6 patients. ALT (95±44) U/L and AST (114±58) U/L before HIFU treatment were reduced to normal in 83.3%(30/36) and 72.9%(35/48) patients, respectively, after the treatment. AFP was lowered by more than 50% in 65.3%(32/49) patients. After HIFU treatment, MRI or CT findings indicated coagulation necrosis and blood supply reduction or disappearance of tumor in the target region.CONCLUSION: HIFU can efficiently treat the patients with liver cancer. It will offer a significant noninvasive therapy for local treatment of liver tumor.

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Section: Discussionmentioning

confidence: 99%

Analysis of clinical effect of high-intensity focused ultrasound on liver cancer

Li¹,

Xu²,

Jiang³

et al. 2004

WJG

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“…During the HIFU procedure, obvious changes in grey scale within the target tissue were immediately detected on the US image after HIFU ablation. Our previous studies indicated that these hyperechoic zones corresponded well to the extent of coagulative necrosis, and that there was a close relationship between the extent of necrosis as measured by gross examination and the hyperechoic extent measured on the US image immediately after FUS in both in vivo and in vitro tissues (Wang et al, 1997;Wu et al, 1998Wu et al, , 2000Wu et al, , 2001bBai et al, 1999). In the clinical treatment of patients with breast cancer, we also found that the hyperechogenic regions were regular in shape and size, and conformed to the extent of coagulative necrosis induced by HIFU ablation (Liu et al, 1998;Cao et al, 2001;Wu et al, 2001;Zhou et al, 2001).…”

Section: Discussionmentioning

confidence: 80%

A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer

et al. 2003

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High-intensity focused ultrasound (HIFU) is a noninvasive treatment that induces complete coagulative necrosis of a tumour at depth through the intact skin. This study was to explore the possibility of using HIFU for the treatment of patients with localised breast cancer in a controlled clinical trial. A total of 48 women with biopsy-proven breast cancer (T 1 -2 , N 0 -2 , M 0 ) were randomised to the control group in which modified radical mastectomy was performed, and the HIFU group in which an extracorporeal HIFU ablation of breast cancer was followed by modified radical mastectomy. Short-term follow-up, pathologic and immunohistochemical stains were performed to assess the therapeutic effects on tumour and complications of HIFU. The results showed that no severe side effect was observed in the HIFU-treated patients. Pathologic findings revealed that HIFU-treated tumour cells underwent complete coagulative necrosis, and tumour vascular vessels were severely damaged. Immunohistochemical staining showed that no expression of PCNA, MMP-9, and CD44v6 was detected within the treated tumour cells in the HIFU group, indicating that the treated tumour cells lost the abilities of proliferation, invasion, and metastasis. It is concluded that, as a noninvasive therapy, HIFU could be effective, safe, and feasible in the extracorporeal treatment of localised breast cancer.

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“…HIFU is an effective treatment for many types of malignant tumor, 5,10,24,25 especially for superficial tumors with poor blood supply. Because ultrasound resistance and absorption are relatively small for these superficial tumors, energy is more easily focused and thus HIFU provides a particularly great outcome for tumor ablation.…”

Section: Resultsmentioning

confidence: 99%

Superficial malignant tumors: Non-invasive treatment with ultrasonographically guided high-intensity focused ultrasound

Li¹,

Zhang²,

Rong³

et al. 2009

Cancer Biology & Therapy

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Targeted damage effects of high intensity focused ultrasound (HIFU) on liver tissues of Guizhou province miniswine

Cited by 42 publications

References 1 publication

Analysis of clinical effect of high-intensity focused ultrasound on liver cancer

Analysis of clinical effect of high-intensity focused ultrasound on liver cancer

A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer

Superficial malignant tumors: Non-invasive treatment with ultrasonographically guided high-intensity focused ultrasound

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