Superficial malignant tumors: Non-invasive treatment with ultrasonographically guided high-intensity focused ultrasound

Li, Chuanxing; Zhang, Weidong; Rong, Zhang; Zhao, Ming; Huang, Zijing; Wu, Peihong; Zhang, Fujun

doi:10.4161/cbt.8.24.10277

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…MRgFUS trials and clinical protocols typically use tumor-to-skin proximity less than 1.0 cm as an exclusion criterion with the intention of avoiding skin burns [ 3 , 11 , 12 ], thereby reducing the number of patients eligible for this noninvasive therapy. If the patient is not excluded outright, the superficial portions of the tumor may not be targeted during treatment, reducing the likelihood of achieving an enduring clinical benefit.…”

Section: Introductionmentioning

confidence: 99%

Design and evaluation of an open-source, conformable skin-cooling system for body magnetic resonance guided focused ultrasound treatments

Merrill

Odéen

Dillon

et al. 2021

International Journal of Hyperthermia

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Purpose: Magnetic resonance guided focused ultrasound (MRgFUS) treatment of tumors uses inter-sonication delays to allow heat to dissipate from the skin and other near-field tissues. Despite inter-sonication delays, treatment of tumors close to the skin risks skin burns. This work has designed and evaluated an open-source, conformable, skin-cooling system for body MRgFUS treatments to reduce skin burns and enable ablation closer to the skin. Methods: A MR-compatible skin cooling system is described that features a conformable skin-cooling pad assembly with feedback control allowing continuous flow and pressure maintenance during the procedure. System performance was evaluated with hydrophone, phantom and in vivo porcine studies. Sonications were performed 10 and 5 mm from the skin surface under both control and forced convective skin-cooling conditions. 3D MR temperature imaging was acquired in real time and the accumulated thermal dose volume was measured. Gross analysis of the skin post-sonication was further performed. Device conformability was demonstrated at several body locations. Results: Hydrophone studies demonstrated no beam aberration, but a 5–12% reduction of the peak pressure due to the presence of the skin-cooling pad assembly in the acoustic near field. Phantom evaluation demonstrated there is no MR temperature imaging precision reduction or any other artifacts present due to the coolant flow during MRgFUS sonication. The porcine studies demonstrated skin burns were reduced in size or eliminated when compared to the control condition. Conclusion: An open-source design of an MRgFUS active skin cooling system demonstrates device conformability with a reduction of skin burns while ablating superficial tissues.

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Section: Introductionmentioning

confidence: 99%

Design and evaluation of an open-source, conformable skin-cooling system for body magnetic resonance guided focused ultrasound treatments

Merrill

Odéen

Dillon

et al. 2021

International Journal of Hyperthermia

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“…Superficial malignant tumors (SMTs), such as breast cancers and melanoma, are increasingly aggressive diseases with strong elusiveness and high metastatic potential. , According to the National Cancer Institute, approximate 90% of surviving rates has been afforded for both breast cancers and melanoma . Thus, effective strategies of precise diagnosis and treatment against superficial malignant tumor lesions are of great significance.…”

mentioning

confidence: 99%

Integrin α_vβ₃-Targeted C-Dot Nanocomposites as Multifunctional Agents for Cell Targeting and Photoacoustic Imaging of Superficial Malignant Tumors

Liu

Chen

et al. 2016

Anal. Chem.

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With a cocktail formulation of soybean milk as a green carbon source and TTDDA as a capping agent, integrin αβ-targeted C-dot nanocomposites (MB-CDs@NH-RGD) have been successfully fabricated via a facile microwaving protocol. Modification of the surface coating and RGD-conjugation endow their superior biocompatibility as well as highly specific targeting profile to αβ-overexpressed cell lines of MDA-MB231 and B16 as representative superficial malignant tumors. Meanwhile, the significant photothermal effect has been generated on irradiation of these targeted C-dot nanocomposites by a pulsed laser, which proved their eligibility for potential thermal ablation therapy. In vivo photoacoustic imaging using these C-dot nanocomposites as novel imaging probes verified their excellent targeting sensitivity and contrast enhancement. This exciting evidence implies a promising strategy to utilize them for multifunctional nanotheranostic purposes in combination with precision diagnosis and photothermal treatment against superficial malignant tumors.

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Ultrasound-Guided Microwave Ablation for Superficial Malignant Tumors

Cai

2014

Microwave Ablation Treatment of Solid Tumors

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Superficial malignant tumors: Non-invasive treatment with ultrasonographically guided high-intensity focused ultrasound

Cited by 4 publications

References 18 publications

Design and evaluation of an open-source, conformable skin-cooling system for body magnetic resonance guided focused ultrasound treatments

Design and evaluation of an open-source, conformable skin-cooling system for body magnetic resonance guided focused ultrasound treatments

Integrin α_vβ₃-Targeted C-Dot Nanocomposites as Multifunctional Agents for Cell Targeting and Photoacoustic Imaging of Superficial Malignant Tumors

Ultrasound-Guided Microwave Ablation for Superficial Malignant Tumors

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Superficial malignant tumors: Non-invasive treatment with ultrasonographically guided high-intensity focused ultrasound

Cited by 4 publications

References 18 publications

Design and evaluation of an open-source, conformable skin-cooling system for body magnetic resonance guided focused ultrasound treatments

Design and evaluation of an open-source, conformable skin-cooling system for body magnetic resonance guided focused ultrasound treatments

Integrin αvβ3-Targeted C-Dot Nanocomposites as Multifunctional Agents for Cell Targeting and Photoacoustic Imaging of Superficial Malignant Tumors

Ultrasound-Guided Microwave Ablation for Superficial Malignant Tumors

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Integrin α_vβ₃-Targeted C-Dot Nanocomposites as Multifunctional Agents for Cell Targeting and Photoacoustic Imaging of Superficial Malignant Tumors