Targeted clindamycin delivery to pilosebaceous units by chitosan or hyaluronic acid nanoparticles for improved topical treatment of acne vulgaris

Topical Treatment for Scarring and Non-Scarring Alopecia: An Overview of the Current Evidence

“…52,71 The material with which the nanoparticles are produced does not have as much impact on the deposition of the nanostructure itself, 54,72,73 but it does affect the time they will have to interact with the skin surface and hair follicles, thinking about systems that are more quickly biodegraded (such as some biodegradable polymers and lipids) and the nature of the interaction with, for example, the sebaceous content of hair follicles. 74 A study compared the follicular deposition of three types of nanoparticles with the same size range (polymer nanospheres of 128 nm, polymer nanocapsules of 257 nm, and lipid core nanocapsules of 197 nm) and found a greater follicular uptake of the lipid core nanocapsules, which were more flexible than the others, and whose lipid content interacts better with the sebum content of the hair follicles. 8,47 Further, we specify and discuss different types of nanoparticles that have already been developed to benefit the topical treatment of alopecia, taking into account whether they are deformable nanoparticles such as lipid nanoparticles and vesicles or rigid systems, such as polymeric or metallic ones.…”

“… 52 , 71 The material with which the nanoparticles are produced does not have as much impact on the deposition of the nanostructure itself, 54 , 72 , 73 but it does affect the time they will have to interact with the skin surface and hair follicles, thinking about systems that are more quickly biodegraded (such as some biodegradable polymers and lipids) and the nature of the interaction with, for example, the sebaceous content of hair follicles. 74 …”

Comparing the delivery to the hair bulb of two fluorescent molecules of distinct hydrophilicities by different nanoparticles and a serum formulation

“…In agreement with the particular aim of selectively target the hair bulb, as more independently of cargo hydrophilicity as possible, our choice lays on the formulation. However, a more complete picture must be obtained in future research by performing a quantitative approach to the amount of cargo that was indeed penetrating into the stratum corneum, hair follicles and viable skin, for each vehicle (Oliveira et al, 2020;Pereira et al, 2021;Tolentino et al, 2021).…”

“…There are several reported studies that analyze the skin and follicular permeation of drug delivery systems (Abd et al, 2018;Blume-Peytavi et al, 2010;Lauterbach and Müller-Goymann, 2015;Ossadnik et al, 2006;Patzelt et al, 2011;Teichmann et al, 2007). Recently, some nanocarriers were developed to deliver topically drugs with interesting potential to treat acne vulgaris, hidradenitis suppurativa, androgenic alopecia and inflammation-based skin and hair disorders (Angelo et al, 2020;Pereira et al, 2021;Tolentino et al, 2021;Ushirobira et al, 2020). The authors have compared the developed vehicles with commercial ones or with the drug in solution and they have elegantly quantified which percentage of the drug penetrated into the skin specifically through the follicular pathway (Angelo et al, 2020;Pereira et al, 2021;Tolentino et al, 2021;Ushirobira et al, 2020).…”

“…Recently, some nanocarriers were developed to deliver topically drugs with interesting potential to treat acne vulgaris, hidradenitis suppurativa, androgenic alopecia and inflammation-based skin and hair disorders (Angelo et al, 2020;Pereira et al, 2021;Tolentino et al, 2021;Ushirobira et al, 2020). The authors have compared the developed vehicles with commercial ones or with the drug in solution and they have elegantly quantified which percentage of the drug penetrated into the skin specifically through the follicular pathway (Angelo et al, 2020;Pereira et al, 2021;Tolentino et al, 2021;Ushirobira et al, 2020). The different nanoparticles and nanocapsules all promoted the targeting of the HFs regarding the other non-structured vehicles.…”