Targeted and Controlled Anticancer Drug Delivery and Release with Magnetoelectric Nanoparticles

Technobiology’s Enabler: The Magnetoelectric Nanoparticle

“…The carboxyl functional groups are used for drug/dye conjugation. These structures have been shown not to cause any toxicity when used in adequate doses and particularly when coated with some lipid molecules such as glycerol mono-oleate (GMO) Kaushik et al 2016;Rodzinski et al 2016). It is noteworthy that the M-H hysteresis loop of these nanostructures does not follow a hysteresis-free dependence typical of superparamagnetic MNPs, as shown in Figure 1C (Islam et al 2008;Nair et al 2013).…”

“…The MENPs-triggered nanoelectroporation was for the first time used to deliver the well-known mitotic inhibitor paclitaxel into ovarian cancer cells while sparing the surrounding normal ovarian cells. Such experiments were conducted both in vitro and in vivo Rodzinski et al 2016). The high specificity of this effect was explained by the substantial difference in the membrane potential between the two cell types.…”

“…The underlying physics of the nanoelectroporation was discussed in the paper by Stimphil et al (2017). To directly measure the tissue specificity of this approach and detect the presence of MENPs with a nanoscale precision, the mode of SEM known as the energy-dispersive spectroscopy (EDS) was used (Rodzinski et al 2016). The EDS-SEM imaging combines the advantages of the elemental com-ac field is "On" Figure 3.…”

Comparative Study of Silver Nanoparticles Coated and Uncoated NiO–Fe2O3–CaO–SiO2–P2O5 Ferromagnetic Bioactive Ceramics

“…Ferromagnetic bioactive materials due to their versatile properties can be used for several applications including catalysts, ferromagnetic resonance imagery, environmental remediation, data storage, and drug delivery. 8 Two major issues concerning use of these materials for drug delivery are as follows: (i) control release of drug 9,10 and (ii) target the specific local area. Drug in controlled manner can improve the recovery rate of deformed bone and also, decrease the over doss risk of drug due to local targeting therapy.…”

Technobiology Paradigm in Nanomedicine: Treating Cancer with MagnetoElectric Nanoparticles

“…Multiferroic nanostructures exist when the crystal structures of two or more primary ferroic materials' properties are united in the same phase. In the case of our coreshell magneto-electric nanoparticles (MENs), composed of a spinel-core cobalt iron oxide (CoFe 2 O 4 ) and perovskite-shell barium titanate (BaTiO 3 ), at the nanoscale creates a nanotechnology capable of being externally controlled to deliver therapeutic drugs to cancer cells on demand with record-high specificity (20). Furthermore, such control can be physically separated via application of d.c. and a.c. magnetic fields, respectively.…”