Comparative Study of Silver Nanoparticles Coated and Uncoated NiO–Fe₂O₃–CaO–SiO₂–P₂O₅ Ferromagnetic Bioactive Ceramics

Abstract

Bioactive ferromagnetic ceramics of system xNiO–(3−x)Fe2O3–52CaO–30SiO2–15P2O5, (x = 0, 3 mol%) have been prepared in the laboratory using sol–gel technique. Silver nanoparticles coating has been undertaken on the surface of synthesized samples. Comparative study of silver nanoparticles coated and uncoated samples has been undertaken with the help of transmission electron microscopy, X‐ray diffraction (XRD), degradation, drug delivery, hemolysis, antimicrobial, and cell culture studies. XRD patterns indicate the growth of hydroxyl apatite layer on the surface of coated as well as uncoated samples. Ferromagnetic properties of samples have been investigated with the help of vibrating sample magnetometer technique. Samples have shown good response as drug carriers under normal conditions as well as under the influence of magnetic field. Drug release mechanism and mesoporus nature of samples have been investigated with the help of Brunauer–Emmett–Teller technique. Nonreactivity of samples (coated and uncoated) with red blood cells and white blood cells show nontoxic nature of the samples. Coated samples have shown better antimicrobial properties against six different microorganisms, including some resistive strain like methicillin‐resistant Staphylococcus aureus with minimum inhibitory concentration of 0.05 mg/ml as compared to uncoated samples. It has been observed that samples also provide a healthy environment for the growth of MG 63 cell lines. It has been noticed that presence of silver nanoparticles on the surface of samples improve degradation and antimicrobial properties.

Elucidating the role of size of hydroxyl apatite particles toward the development of competent antiosteoporotic bioceramic materials: In vitro and in vivo studies

“…[30][31][32][33][34] Figure 4a,b shows the drug release profile for pH $4.5 and 7.5, respectively. To study in vitro controlled drug release from prepared Eu-mHAp and Eu-nHAp particles, gentamycin as an antibiotic has been chosen because it can be used to treat several types of bacterial infections including bone infections and pelvic inflammatory diseases.…”

“…33,34 Results of cytotoxicity are given in Figure 6. Besides chemical composition, size and surface to volume ratio of particles can also affect toxicity.…”

“…PBS with two different pH (4.5 and 7.4) values has been selected to study the pH-dependent release profile of drug from Eu-mHAp and Eu-nHAp particles at 37 C. Details of experiment procedure are reported elsewhere by the authors. [30][31][32][33][34] Figure 4a,b shows the drug release profile for pH $4.5 and 7.5, respectively. In case of Eu-nHAp particles, $56% of the drug has released in first 20 h in pH $4.5 while in case of Eu-mHAp particles, cumulative release is $30% at same pH value.…”

“…The procedure of the experiment is explained elsewhere by the authors. 33,34 Results of cytotoxicity are given in Figure 6. Results indicate that at concentration 2 and 10 mg/mL, Eu-nHAp is nontoxic in nature with cell viability more than control.…”

Case Study of Somaclonal Variation in Resistance GenesMloandPme3in Flaxseed (Linum usitatissimumL.) Induced by Nanoparticles

“…Gold NPs are widely used in bionanotechnologies because of their unique properties and the possibility to modify their surface with different functional groups. Silver NPs are among the well-studied nanomaterials and represent a special interest as carrier of drug molecules and other bioactive substances [ 21 ].…”