Target Volume Definition for Stereotactic Radiosurgery (SRS) Of Cerebral Cavernous Malformations (CCMS)

Sager, Omer

doi:10.19080/ctoij.2020.15.555917

Cited by 17 publications

(2 citation statements)

References 23 publications

(23 reference statements)

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“…In this context, multimodality imaging may add to the accuracy of target definition for radiosurgery of intracranial GCTs. Indeed several other studies have demonstrated refined treatment volume determination by including MRI to the process of target determination [39][40][41][42][43][44][45][46][47][48][49][50][51].…”

Section: Resultsmentioning

confidence: 99%

Determination of Radiosurgery Treatment Volume for Intracranial Germ Cell Tumors (GCTS)

Beyzadeoğlu¹,

Dincoglan²,

Sager³

et al. 2020

AJPNMS

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Background: Radiation therapy (RT) volumes for intracranial germ cell tumors (GCTs) may include focal treatment volumes, whole ventricle irradiation, whole brain irradiation, or irradiation of the entire neuroaxis. RT doses and volumes for management of primary intracranial GCTs have been an area of active research over the years. Improved sparing of critical organs by use of less extensive RT volumes and lower doses has been investigated for avoiding excessive morbidity of treatment. Herein, we assess intracranial GCT treatment volume determination. Methods: Treatment volume definition for intracranial GCT by incorporation of Magnetic Resonance Imaging (MRI) was comparatively assessed in our study. Reference volume for comparison purposes was defined after thorough assessment and collaboration of the board certified radiation oncologists. Definition of radiosurgery target volume was based solely on CT images or fusion of CT with MRI. Comparative evaluation of treatment volume determination was performed. Results: Ground truth target volume defined after thorough evaluation and collaboration of the board certified radiation oncologists was similar with treatment volume definition based on CT-MR fusion based imaging. Conclusions: In conclusion, radiosurgery treatment planning for intracranial GCTs may be improved by incorporation of MRI into target definition process. Clearly, further studies are warranted to draw firm conclusions on optimal target definition for intracranial GCT radiosurgery.

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Section: Resultsmentioning

confidence: 99%

Determination of Radiosurgery Treatment Volume for Intracranial Germ Cell Tumors (GCTS)

Beyzadeoğlu¹,

Dincoglan²,

Sager³

et al. 2020

AJPNMS

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“…In this context, incorporation of multimodality imaging can be used for improving the precision of target localization, and integrated use of fused CT and MR images can facilitate optimization of treatment volume designation for successful RT applications. Indeed, several studies addressed the utility of multmodality imaging for RT target definition [46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63]. Our study may add to the literature given the limited data regarding the utility of multimodality imaging based target definition for irradiation of hemangiopericytomas.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Target Volume Definition for Irradiation of Hemangiopericytomas: An Original Article

Sager¹

2020

CTOIJ

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Background: Hemangiopericytomas arise from the mesenchymal cells with pericytic differentiation. Clinical course of these rare tumors may be aggressive with high propensity for local recurrence and metastases. Radical resection is the treatment of choice for lesions amenable to surgery. Nevertheless, radiation therapy (RT) may have a role in management of hemangiopericytomas either as an adjunctive, salvage or primary treatment, or for palliation of metastases in selected patients. Target volume definition is a critical aspect of RT.Objective: Aim of this study is to assess incorporation of multimodality imaging with magnetic resonance imaging (MRI) into target volume definition for irradiation of hemangiopericytomas. Methods:In this study, treatment volume definition with multimodality imaging by incorporating MRI or by use of computed tomography (CT)-simulation images only was comparatively evaluated for patients with hemangiopericytoma.Results: Ground truth target volume defined by the board-certified radiation oncologists following meticulous evaluation, colleague peer review, collaboration, and ultimate consensus was found to be identical with target determination based on CT-MR fusion based imaging in this study.Conclusion: Accurate target volume determination is an indispensable part of RT for management of hemangiopericytomas. Incorporation of MRI in the target volume definition process may be considered for optimization of treatment volume designation for successful RT applications. Clearly, future studies are required to shed light on this issue.

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Assessment of Target Volume Definition for Radiosurgery of Atypical Meningiomas with Multimodality Imaging

Demiral

Beyzadeoğlu

Dincoglan

et al. 2020

JHOR

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Objective Meningiomas are most common intracranial benign tumors comprising around one third of all intracranial neoplasms, and typically have benign and indolent nature with slow-growing behaviour. Benign meningiomas are slow growing tumors typically following an indolent disease course. Nevertheless, atypical or anaplastic meningiomas may follow a more aggressive disease course with invasion of critical structures and recurrences. In the current study, we evaluate the incorporation of magnetic resonance imaging (MRI) for radiosurgery treatment planning of atypical meningiomas. Materials and Methods Atypical meningioma radiosurgery target volume determination with and without incorporation of MRI has been evaluated. Ground truth target volume used as the reference has been outlined by the board-certified group of radiation oncologists after comprehensive assessment, thorough collaboration and consensus. Results Target volume definition by use of Computed Tomography (CT)-only imaging and by CT-MR fusion based imaging has been comparatively evaluated in this study for linear accelerator (LINAC)-based radiosurgical management of atypical meningioma. Ground truth target volume defined by the board-certified radiation oncologists after detailed evaluation, collaboration, colleague peer review and consensus has been found to be identical to target determination by use of CT-MR fusion based imaging. Conclusion Despite significant progress in neurosurgical techniques over the years, complete surgical resection may not be feasible in the presence of meningiomas located at eloquent brain areas in close association with important neurovascular structures. RT may have a role in multidisciplinary management of meningiomas. Incorporation of MRI into treatment planning for radiosurgery of atypical meningiomas may improve target definition despite the need for further supporting evidence.

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Target Volume Definition for Stereotactic Radiosurgery (SRS) Of Cerebral Cavernous Malformations (CCMS)

Cited by 17 publications

References 23 publications

Determination of Radiosurgery Treatment Volume for Intracranial Germ Cell Tumors (GCTS)

Determination of Radiosurgery Treatment Volume for Intracranial Germ Cell Tumors (GCTS)

Assessment of Target Volume Definition for Irradiation of Hemangiopericytomas: An Original Article

Assessment of Target Volume Definition for Radiosurgery of Atypical Meningiomas with Multimodality Imaging

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