Target/signalling pathways of natural plant-derived radioprotective agents from treatment to potential candidates: A reverse thought on anti-tumour drugs

Nanodrugs with intrinsic radioprotective exertion: Turning the double‐edged sword into a single‐edged knife

“…[ 53–56 ] Natural extracts or biologically active ingredients in plants can reduce oxidative stress‐arised damages and enhance the body's antioxidant ability, endowing them with a considerable ability to boost radiation protection. [ 57 ] As a paradigm, flavonoids as a class of natural substances isolated from plants are originally extracted from Chinese herbal medicine, and they usually include epicatechin, apigenin, and silymarin, all of which have been proven to have neuroprotective and radioprotective characteristics. [ 58–60 ] In principle, flavonoids as potent antioxidants can inhibit regulatory enzymes or transcription factors involved in the control of inflammatory mediators, influence oxidative stress through interactions with DNA, and enhance genomic integrity.…”

Biyang floral mushroom-derived exosome-like nanovesicles: characterization, absorption stability and ionizing radiation protection

“…Development of new natural radioprotective agents from natural products has gradually become a hot spot for scientific research. 15,16 Among the many natural products, large edible fungi are famous for their unique flavor and nutritional value, and their pharmacological effects have attracted much attention. 17 Floral mushrooms are a large edible fungus, belonging to Tricholomataceae, Agaricales and Basidiomycotina, which are rich in polysaccharides, amino acids, vitamins, and other components.…”

“…Development of new natural radioprotective agents from natural products has gradually become a hot spot for scientific research. 15,16…”

Cytotoxicity of iodine-131 radiopharmaceutical in tumor and non-tumor human cells and radioprotection by integral juices of Vitis labrusca L.

“…The use of radiopharmaceuticals in carcinoma treatments is based on the fact that when they are present, in sufficient quantity in the tissue or organ, they can cause cell destruction and prevent the formation of new tissues, mainly by excitation and ionization, which may alter cell molecules chemically and result in their death (Fischer et al, 2018;Asadian et al, 2020;Nouailhetas et al, 2021). Besides, ionizing radiation may cause swelling or damage of the nucleus and cell structure as a whole, increased cell media viscosity, increased permeability, cell membrane damage, or cell cycle arrest (Fischer et al, 2018), induction of apoptosis, necrosis and autophagy, as well as organ fibrosis, atrophy and inflammation (Yun and Wang, 2017). However, these effects may also affect healthy cells (Murayama et al, 2021) and pulmonary complications have been evidenced in patients undergoing I-131-lipiodol due to tumoral arteriovenous permeation resulting in migration of the molecule to the pulmonary circulation (Ahmadzadehfar et al, 2011;Costa and Sapienza, 2012).…”

“…The evaluation of natural compounds as radioprotective agents is relevant due to their non-toxic essence, their easy availability (Yun and Wang, 2017;Kuruba and Gollapalli, 2018;Dowlath et al, 2021;Kumar et al, 2021), their antioxidant activity and the possibility that they may act effectively in reducing cancer incidence without adverse side effects (Fischer et al, 2018;Kuruba and Gollapalli, 2018;Dowlath et al, 2021) used: radiation fluence rate of 65.6 J/m 2 at a distance of 30cm from the light source. The grapes were arranged in a single layer in trays that were irradiated in a cabin equipped with three UV-C lamps (Philips ® 90 W) for 5 minutes.…”