Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes

Ringhieri, Paola; Iannitti, Roberta; Nardon, Chiara; Palumbo, Rosanna; Fregona, Dolores; Morelli, Giancarlo; Accardo, Antonella

doi:10.1016/j.ijpharm.2014.07.014

Cited by 29 publications

(29 citation statements)

References 34 publications

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“…Several features of the commercial phospholipids, such as the length, the unsaturation degree of the alkyl portion and the charge of the head-group deeply influence lipid bilayer microfluidity, that is directly responsible for incorporation and retention of pharmaceutically relevant molecules (anticancer or anti-inflammatory drugs, nucleic acids, metal based contrast agents) (21)(22)(23). High rigidity of the bilayer corresponds to an improved retention of the encapsulated drug, while high microfluidity can lead to a reduction of the incorporation capability (23)(24)(25).…”

Section: Resultsmentioning

confidence: 99%

The influence of liposomal formulation on the incorporation and retention of PNA oligomers

Ringhieri

Avitabile

Morelli

et al. 2016

Colloids and Surfaces B: Biointerfaces

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Liposomal formulations composed of phospholipids with different unsaturation degrees, head groups and at different cholesterol content have been tested for the encapsulation of Peptide Nucleic Acid (PNA) oligomers. The best loading capability (177μg, ER%=87.2) was obtained for pure liposomes of phosphatidylglycerol (DOPG) with negatively charged head group. The insertion of a 10-20% of cholesterol in DOPG based liposomes provides a slight decrease (∼160μg) of the PNA loading. On the other hand, the cholesterol addition (20-30%) slows down the PNA's release (∼27%) in fetal bovine serum from the liposomal formulation. Based on the encapsulation and the release properties, PEGylated DOPG liposomes with a percentage of cholesterol of 10-20% are the optimal formulation for the loading of PNA-a210.

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Section: Resultsmentioning

confidence: 99%

The influence of liposomal formulation on the incorporation and retention of PNA oligomers

Ringhieri

Avitabile

Morelli

et al. 2016

Colloids and Surfaces B: Biointerfaces

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“…In addition BnR agonists have been one of the main targeting agents coupled to various nanoparticle carriers to assess delivery [44,342] or for targeted delivery of various cytotoxic agents including chemotherapeutic agents [docataxel [157], doxorubicin [1,3]]; radiolabeled analogues [140]; or gold nanoparticles [45]. Similarly various BnR agonists have been coupled to liposomes or micelles for target delivery of various cytotoxic agents including chemotherapeutic agents [4], radiolabeled compounds [2] or various cytotoxic Au-coupled compounds [289]. …”

Section: Bnr Function In Disease and A Therapeutic Target (Table 3)mentioning

confidence: 99%

Insights into bombesin receptors and ligands: Highlighting recent advances

et al. 2015

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This following article is written for Prof. Abba Kastin’s Festschrift, to add to the tribute to his important role in the advancement of the role of peptides in physiological, as well as pathophysiological processes. There have been many advances during the 35 years of his prominent role in the Peptide field, not only as editor of the journal Peptides, but also as a scientific investigator and editor of two volumes of the Handbook of Biological Active Peptides [146,147]. Similar to the advances with many different peptides, during this 35 year period, there have been much progress made in the understanding of the pharmacology, cell biology and the role of (Bombesin) Bn receptors and their ligands in various disease states, since the original isolation of bombesin from skin of the European frog Bombina bombina in 1970 [76]. This paper will briefly review some of these advances over the time period of Prof Kastin 35 years in the peptide field concentrating on the advances since 2007 when many of the results from earlier studies were summarized [128,129]. It is appropriate to do this because there have been 280 articles published in Peptides during this time on Bombesin-related peptides and it accounts for almost 5% of all publications. Furthermore, 22 Bn publications we have been involved in have been published in either Peptides [14,39,55,58,81,92,93,119,152,216,225,226,231,280,302,309,355,361,362] or in the Prof Kastin’s Handbook of Biological Active Peptides [137,138,331].

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“…Apart from using strong sigma-donor ligands [31][32][33][34][35], another feasible approach to stabilize the highly oxidizing gold(III) metal center is the utilization of drug carriers or encapsulating materials. To facilitate the transport of anti-cancer active gold(III) complexes in biologically-relevant systems, some recent studies have demonstrated the use of gelatin-acacia [36], polyethylene glycol [37,38],…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Enhanced anti-cancer activities of a gold(III) pyrrolidinedithiocarbamato complex incorporated in a biodegradable metal-organic framework

Sun

Zhang

et al. 2016

Journal of Inorganic Biochemistry

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Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes

Cited by 29 publications

References 34 publications

The influence of liposomal formulation on the incorporation and retention of PNA oligomers

The influence of liposomal formulation on the incorporation and retention of PNA oligomers

Insights into bombesin receptors and ligands: Highlighting recent advances

Enhanced anti-cancer activities of a gold(III) pyrrolidinedithiocarbamato complex incorporated in a biodegradable metal-organic framework

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