Enhanced anti-cancer activities of a gold(III) pyrrolidinedithiocarbamato complex incorporated in a biodegradable metal-organic framework

Sun, Raymond Wai‐Yin; Zhang, Ming; Li, Dan; Li, Mian; Wong, Alice S.T.

doi:10.1016/j.jinorgbio.2016.06.020

Cited by 25 publications

(8 citation statements)

References 52 publications

(65 reference statements)

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“…213 In 2016, an anticancer active gold( iii ) pyrrolidinedithiocarbamato complex [(PDTC)Au( iii )Cl 2 ] ( 283 ) was synthesized and characterized by Sun et al Compared to the pyrrolidinedithiocarbamate ligand itself, this gold( iii ) complex displayed up to 33-fold higher anticancer potency toward a panel of cancer cell lines. The gold complex 283 exhibited the best antiproliferative activity on the A2780cis cell line with an IC 50 value of 1.3 ± 0.1 μM 214 (Fig. 26).…”

Section: Gold(iii) Complexes As Anticancer Agentsmentioning

confidence: 98%

Recent development of gold(i) and gold(iii) complexes as therapeutic agents for cancer diseases

Chang

et al. 2022

Chem. Soc. Rev.

107

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Section: Gold(iii) Complexes As Anticancer Agentsmentioning

confidence: 98%

Recent development of gold(i) and gold(iii) complexes as therapeutic agents for cancer diseases

Chang

et al. 2022

Chem. Soc. Rev.

107

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“…This type of PS is useless by itself due to its low solubility in biological media, but when incorporated into metallizations, it can be internalized into cells. Based on this theory the conjugation of porphyrin with metals has received much attention [45].…”

Section: Discussionmentioning

confidence: 99%

Photodynamic therapy in colorectal cancer using photosensitizers functionalized by arene-ruthenium complexes

Massoud

Pinon

Gallardo-Villagrán

et al. 2022

Preprint

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Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide and one of the main causes of cancer deaths in the global population. First-line treatment usually includes surgical procedures followed by combination chemotherapy. Despite the improvements in CRC treatments, the mortality rate remains very high, leading consequently to conventional treatment resistance. Several therapies were enrolled to this content in a way to find the best solutions for this disease. Photodynamic therapy (PDT) using photosensitizers (PS) presents itself as an original innovative therapeutic strategy that strongly limits the undesirable side effects of conventional treatment. However, low physiological solubility and a lack of selectivity of PS towards tumor sites are the principal restrictions of their current clinical use. Indeed, drug delivery systems are currently a key issue in cancer therapy. To overcome the problem of solubility and stability of PS such as porphyrins and their derivatives, metallic assemblies based on arene-ruthenium (Ru) units have begun to attract considerable attention as PS delivery systems. The purpose of this study was to demonstrate firstly the interest in the vectorization of tetrapyridylporphin (TPyP-arene-Ru) and Zn-tetrapyridylporphin arene-ruthenium (Zn-TPyP-arene-Ru) metallacages to increase their solubility in biological media and then, consequently their anticancer efficacy in PDT. Secondly, to elucidate the anticancer mechanism as well as identify the cell death process mediated by these new vectorized PS. The results showed that the two PS-arene-Ru complexes have a strong photocytotoxic effect after photoactivation on human HCT116 and HT-29 colorectal cancer cell lines. TPyP-arene-Ru-PDT induced outstanding cytotoxicity when compared to the Zn-TPyP-arene-Ru analogue. The two complexes show no significant effect on proliferation in the dark. In addition, results demonstrated that these two PS-arene-Ru complexes-PDT induce an apoptotic process through the appearance of a sub-G1 peak, phosphatidylserines externalization, poly-ADP ribose polymerase (PARP) cleavage and DNA fragmentation. Thus, our data contribute to highlighting that the incorporation of porphyrins in Ru-based assemblies could be an efficient vectorized system to treat CRC by PDT.

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“…• Highly porous materials are necessary for drug delivery using post-synthetic non-covalent loading [59,130,138,169,192,193,206,.…”

Section: Postsynthetic Noncovalent Loading Systemsmentioning

confidence: 99%

MOF materials as therapeutic agents, drug carriers, imaging agents and biosensors in cancer biomedicine: Recent advances and perspectives

Bieniek

Terzyk

Wiśniewski

et al. 2021

Progress in Materials Science

152

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Enhanced anti-cancer activities of a gold(III) pyrrolidinedithiocarbamato complex incorporated in a biodegradable metal-organic framework

Cited by 25 publications

References 52 publications

Recent development of gold(i) and gold(iii) complexes as therapeutic agents for cancer diseases

Recent development of gold(i) and gold(iii) complexes as therapeutic agents for cancer diseases

Photodynamic therapy in colorectal cancer using photosensitizers functionalized by arene-ruthenium complexes

MOF materials as therapeutic agents, drug carriers, imaging agents and biosensors in cancer biomedicine: Recent advances and perspectives

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