Abstract:Complex mixtures of unknown contaminants present a challenge to identify toxicological risks without using large numbers of animals and labour-intensive screens of all organs. This study examined soil extracts from a legacy contaminated pesticide packaging and blending site. HepG2 cytotoxicity was used as an initial screen of 18 soil samples to identify the most toxic extracts for testing in animals. Then, target organ toxicities were identified following biweekly oral gavage for one month of three soil extrac… Show more
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