Target neuron prespecification in the olfactory map of Drosophila

Jefferis, Gregory S.X.E.; Marin, Elizabeth C.; Stocker, Reinhard F.; Luo, Liqun

doi:10.1038/35102574

Cited by 389 publications

(464 citation statements)

References 26 publications

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“…A heat-shock pulse at 37°C in a water bath for 1-2 h was given at optimal time points to induce single-cell clones in PNs projecting to the DL-1 glomerulus. The time points (between 0 and 60 h after larval hatching) were chosen after G. Jefferis (96). Heat-shocked larvae were transferred back to 25°C, raised to adulthood, and the adult flies were dissected 1-4 d after eclosion.…”

Section: Multiple Synaptic Sites For Translational Control Necessary mentioning

confidence: 99%

FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control

Sudhakaran

Hillebrand

Dervan

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

112

143

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Fragile X mental retardation protein (FMRP) and Ataxin-2 (Atx2) are triplet expansion disease-and stress granule-associated proteins implicated in neuronal translational control and microRNA function. We show that Drosophila FMRP (dFMR1) is required for long-term olfactory habituation (LTH), a phenomenon dependent on Atx2-dependent potentiation of inhibitory transmission from local interneurons (LNs) to projection neurons (PNs) in the antennal lobe. dFMR1 is also required for LTH-associated depression of odor-evoked calcium transients in PNs. Strong transdominant genetic interactions among dFMR1, atx2, the deadbox helicase me31B, and argonaute1 (ago1) mutants, as well as coimmunoprecitation of dFMR1 with Atx2, indicate that dFMR1 and Atx2 function together in a microRNA-dependent process necessary for LTH. Consistently, PN or LN knockdown of dFMR1, Atx2, Me31B, or the miRNA-pathway protein GW182 increases expression of a Ca2+/calmodulin-dependent protein kinase II (CaMKII) translational reporter. Moreover, brain immunoprecipitates of dFMR1 and Atx2 proteins include CaMKII mRNA, indicating respective physical interactions with this mRNA. Because CaMKII is necessary for LTH, these data indicate that fragile X mental retardation protein and Atx2 act via at least one common target RNA for memory-associated long-term synaptic plasticity. The observed requirement in LNs and PNs supports an emerging view that both presynaptic and postsynaptic translation are necessary for long-term synaptic plasticity. However, whereas Atx2 is necessary for the integrity of dendritic and somatic Me31B-containing particles, dFmr1 is not. Together, these data indicate that dFmr1 and Atx2 function in long-term but not short-term memory, regulating translation of at least some common presynaptic and postsynaptic target mRNAs in the same cells.synapse plasticity | olfactory memory | neural circuits | neurological disease

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Section: Multiple Synaptic Sites For Translational Control Necessary mentioning

confidence: 99%

FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control

Sudhakaran

Hillebrand

Dervan

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

112

143

View full text Add to dashboard Cite

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“…Axonal targeting and synapse formation are complex cellular processes, requiring that a neuron project along the correct pathway, choose the appropriate target, and construct and maintain a functional synapse (Tessier-Lavigne and Goodman, 1996). Although neuronal activity is involved in these processes (Catalano and Shatz, 1998;Ruthazer and Cline, 2004), recent evidence suggests that the formation of synapses may be more âhard-wiredâ than previously thought due to specific molecular cues (Jefferis et al, 2001;Clandinin and Zipursky, 2002;Ackley and Jin, 2004). A number of molecules have been identified to play a prominent role in axonal guidance, including semaphorins, ephrins, netrins, neurotrophins, and receptor protein tyrosine phosphatases.…”

Section: Introductionmentioning

confidence: 99%

The atypical cadherin flamingo regulates synaptogenesis and helps prevent axonal and synaptic degeneration in Drosophila

Bao

Berlanga

Xue

et al. 2007

Molecular and Cellular Neuroscience

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The formation of synaptic connections with target cells and maintenance of axons are highly regulated and crucial for neuronal function. The atypical cadherin and G-protein-coupled receptor Flamingo and its orthologs in amphibians and mammals have been shown to regulate cell polarity, dendritic and axonal growth, and neural tube closure. However, the role of Flamingo in synapse formation and function and in axonal health remains poorly understood. Here we show that fmi mutations cause a significant increase in the number of ectopic synapses on muscles and result in the formation of novel en passant synapses along axons, and unique presynaptic varicosities, including active zones, within axons. fmi mutations also cause defective synaptic responses in a small subset of muscles, an agedependent loss of muscle innervation and a drastic degeneration of axons in 3 rd instar larvae without an apparent loss of neurons. Neuronal expression of Flamingo rescues all of these synaptic and axonal defects and larval lethality. Based on these observations, we propose that Flamingo is required in neurons for synaptic target selection, synaptogenesis, the survival of axons and synapses, and adult viability. These findings shed new light on a possible role for Flamingo in progressive neurodegenerative diseases.

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“…The nature of the interactions between the olfactory epithelium (OE), olfactory bulb (OB) and olfactory cortex at early developmental stages is currently providing us with much food for thought. 4,5 In order to gain a better insight into the mechanisms involved in the specification and development of the olfactory system, this review aims to explore recent data from different developmental studies. Our studies in the pax-6 mutant mouse led us to conclude that the initial establishment of the OB central projections can proceed independently of the olfactory sensory axons from the OE.…”

Section: Introductionmentioning

confidence: 99%

The olfactory bulb as an independent developmental domain

López‐Mascaraque

Castro

2002

Cell Death Differ

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The olfactory system is a good model to study the mechanisms underlying guidance of growing axons to their appropriate targets. The formation of the olfactory bulb involves differentiation of several populations of cells and the initiation of the central projections, all under the temporal and spatial patterns of gene expression. Moreover, the nature of interactions between the olfactory epithelium, olfactory bulb and olfactory cortex at early developmental stages is currently of great interest. To explore these questions more fully, the present review aims to correlate recent data from different developmental studies, to gain insight into the mechanisms involved in the specification and development of the olfactory system. From our studies in the pax6 mutant mice (Sey Neu /Sey Neu ), it was concluded that the initial establishment of the olfactory bulb central projections is able to proceed independently of the olfactory sensory axons from the olfactory epithelium. The challenge that now remains is to consider the validity of the olfactory bulb as an independent development domain. In the course of evaluating these ideas, we will review the orchestra of molecular cues involved in the formation of the projection from the OB to the olfactory cortex.

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Target neuron prespecification in the olfactory map of Drosophila

Cited by 389 publications

References 26 publications

FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control

FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control

The atypical cadherin flamingo regulates synaptogenesis and helps prevent axonal and synaptic degeneration in Drosophila

The olfactory bulb as an independent developmental domain

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