Target molecule-responsive hydrogels designed via molecular imprinting using bisphenol A as a template

Kawamura, Akifumi; Kiguchi, Tadahiro; Nishihata, Takeshi; Uragami, Tadashi; Miyata, Takashi

doi:10.1039/c4cc01187b

Cited by 53 publications

(51 citation statements)

References 20 publications

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“…10 For example, Miyata et al 52 prepared the bisphenol A (BPA)-imprinted hydrogel using b-CD as a ligand and a minute amount of cross-linker. Sandwich-like CD-BPA-CD complexes were formed between b-CDs with a polymerizable acryloyl group (acryloyl-CD) and BPA, leading to an increase in the apparent crosslinking density of the BPA-imprinted and non-imprinted hydrogels, followed by shrinkage in response to BPA.…”

Section: Functional Monomersmentioning

confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

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a Molecular imprinting technology (MIT), often described as a method of making a molecular lock to match a molecular key, is a technique for the creation of molecularly imprinted polymers (MIPs) with tailor-made binding sites complementary to the template molecules in shape, size and functional groups. Owing to their unique features of structure predictability, recognition specificity and application universality, MIPs have found a wide range of applications in various fields. Herein, we propose to comprehensively review the recent advances in molecular imprinting including versatile perspectives and applications, concerning novel preparation technologies and strategies of MIT, and highlight the applications of MIPs. The fundamentals of MIPs involving essential elements, preparation procedures and characterization methods are briefly outlined.Smart MIT for MIPs is especially highlighted including ingenious MIT (surface imprinting, nanoimprinting, etc.), special strategies of MIT (dummy imprinting, segment imprinting, etc.) and stimuli-responsive MIT (single/dual/ multi-responsive technology). By virtue of smart MIT, new formatted MIPs gain popularity for versatile applications, including sample pretreatment/chromatographic separation (solid phase extraction, monolithic column chromatography, etc.) and chemical/biological sensing (electrochemical sensing, fluorescence sensing, etc.). Finally, we propose the remaining challenges and future perspectives to accelerate the development of MIT, and to utilize it for further developing versatile MIPs with a wide range of applications (650 references).

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Section: Functional Monomersmentioning

confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

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“…By utilizing photopolymerization, micron-sized moleculeimprinted hydrogels with a minute number of crosslinkers were prepared 15 . Differing from standard molecular imprinting, which uses a large number of crosslinkers to attach functional groups at a strictly defined, optimal position within the molecular recognition site, molecule-imprinted hydrogels were successfully prepared by using a minute amount of crosslinker 12,21 . The moleculeimprinted hydrogels were able to selectively recognize a target molecule, and the hydrogels shrank with an increase in the concentration of the target molecule because the gel networks formed by molecular imprinting memorized the target molecule and formed dynamic crosslinks composed of molecular complexes.…”

Section: Micron-sized Molecule-responsive Hydrogelsmentioning

confidence: 99%

“…The moleculeimprinted hydrogels were able to selectively recognize a target molecule, and the hydrogels shrank with an increase in the concentration of the target molecule because the gel networks formed by molecular imprinting memorized the target molecule and formed dynamic crosslinks composed of molecular complexes. For example, a bisphenol A (BPA)-imprinted hydrogel was prepared by using b-cyclodextrin (CD) as a ligand for BPA 21 . The BPA-imprinted hydrogel was prepared as Therefore, BPA-imprinted micro-hydrogels exhibiting rapid volume changes were prepared on a glass substrate via photopolymerization using a standard fluorescence microscope 15 .…”

Section: Micron-sized Molecule-responsive Hydrogelsmentioning

confidence: 99%

Design of nano- and micro-structured molecule-responsive hydrogels

Kawamura

2017

Polym J

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Stimuli-responsive hydrogels have attracted considerable attention for use as smart materials, such as in molecular sensors and drug delivery systems. With a focus on their crosslinking density, we have prepared various molecule-responsive hydrogels that undergo volume changes in response to target molecules based on the association/dissociation of molecular complexes that act as crosslinkers. Recent developments in polymerization techniques enabled us to design various types of polymer nanomaterials. This focus review provides a short overview of our recent studies on the nano-and micro-structured molecule-responsive hydrogels prepared using various polymerization techniques, such as photopolymerization, surface-initiated atom transfer radical polymerization, and soap-free emulsion polymerization. The nano-and micro-structured molecule-responsive hydrogels showed not only rapid swelling/shrinkage in response to a target molecule owing to their large surface area but also smart functions, such as autonomous molecule-responsive microchannel flow regulation and highly sensitive detection of a target molecule. The smart functions of nano-and micro-structured molecule-responsive hydrogels can provide tools for constructing, for example, sensors, microdevices and smart biomaterials.

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“…The article gave a systematic classification of stimuli-responsive MIPs in DDS. Moreover, the development of stimuli-responsive MIPs, such as their applications and methodologies, has grown rapidly in recent years [6,[30][31][32]. Therefore, in this review, we provide an overview of different responsive MIPs developed until now (Table 1), especially their synthetic methods, material formats and applications, furthermore, considering the challenges presently encountered and some feasible resolutions.…”

Section: Introductionmentioning

confidence: 99%

“…Currently, a variety of intelligent MIPs have been prepared which respond to specific stimuli such as changes in temperature [24], pH [25], incident light [26], ionic strength [27], or even the presence of a specific molecule [6,28]. Puoci et al have reviewed work in the field until 2008 with special focus on a series of stimuli-responsive MIPs and their applications in drug delivery systems (DDS) [29].…”

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Polymers with Stimuli-Responsive Affinity: Progress and Perspectives

et al. 2015

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Intelligent stimuli-responsive molecularly imprinted polymers (SR-MIPs) have attracted considerable research interest in recent years due to the potential applications in drug delivery, biotechnology and separation sciences. This review comprehensively summarizes various SR-MIPs, including the design and applications of thermo-responsive MIPs, pH-responsive MIPs, photo-responsive MIPs, biomolecule-responsive MIPs and ion-responsive MIPs. Besides the development of current SR-MIPs, the advantages as well as the disadvantages of current SR-MIPs were also displayed from different angles, especially preparation methods and application fields. We believe this review will be helpful to guide the design, development and application of SR-MIPs.Polymers 2015, 7 1690

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Target molecule-responsive hydrogels designed via molecular imprinting using bisphenol A as a template

Cited by 53 publications

References 20 publications

Molecular imprinting: perspectives and applications

Molecular imprinting: perspectives and applications

Design of nano- and micro-structured molecule-responsive hydrogels

Molecularly Imprinted Polymers with Stimuli-Responsive Affinity: Progress and Perspectives

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