Target gene delivery from targeting ligand conjugated chitosan–PEI copolymer for cancer therapy

Nam, Joung-Pyo; Nah, Jae‐Woon

doi:10.1016/j.carbpol.2015.08.053

Cited by 75 publications

(41 citation statements)

References 37 publications

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“…Regarding the previous section, CS is a unique cationic biocompatible and biodegradable (see Section 5) polysaccharide that can be modified, as required, according to the needed end-use application. This is particularly true for biomedical and pharmaceutical applications ranging from drug delivery systems [164] to functional biomaterials [165], also considering tissue engineering [166], cell culturing [167], regenerative scaffolds [168], wound healing [169], smart hydrogels [170], active nanoparticles [171], anticoagulants [172], gene therapy [173], etc. (Figure 9).…”

Section: Biomedical and Pharmaceutical Functionsmentioning

confidence: 99%

Modification of Chitosan for the Generation of Functional Derivatives

et al. 2019

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Today, chitosan (CS) is probably considered as a biofunctional polysaccharide with the most notable growth and potential for applications in various fields. The progress in chitin chemistry and the need to replace additives and non-natural polymers with functional natural-based polymers have opened many new opportunities for CS and its derivatives. Thanks to the specific reactive groups of CS and easy chemical modifications, a wide range of physico-chemical and biological properties can be obtained from this ubiquitous polysaccharide that is composed of β-(1,4)-2-acetamido-2-deoxy-d-glucose repeating units. This review is presented to share insights into multiple native/modified CSs and chitooligosaccharides (COS) associated with their functional properties. An overview will be given on bioadhesive applications, antimicrobial activities, adsorption, and chelation in the wine industry, as well as developments in medical fields or biodegradability.

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Section: Biomedical and Pharmaceutical Functionsmentioning

confidence: 99%

Modification of Chitosan for the Generation of Functional Derivatives

et al. 2019

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“…The high amine content, however, contributes to the enhanced cytotoxicity that usually limits PEI utilization for in vivo exploitation. [17,18] Various synthetic strategies for improvement of PEI vector properties have been developed including incorporation of biodegradable linkers, [19,20] attachment of functional molecules to target specific cells or tissues, [21,22] and copolymerization, [23][24][25] which is the most widely used approach. Introduction of hydrophilic and biocompatible moieties such as poly(ethylene glycol) (PEG) into the polymer chain is known to reduce protein adhesion, impart stealth properties of the systems thus restricting molecular recognition, and improve the cellular uptake.…”

Section: Introductionmentioning

confidence: 99%

DNA delivery systems based on copolymers of poly (2‐methyl‐2‐oxazoline) and polyethyleneimine: Effect of polyoxazoline moieties on the endo‐lysosomal escape

Haladjova

Smolíček

Ugrinova

et al. 2020

J of Applied Polymer Sci

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Poly(2‐methyl‐2‐oxazoline)‐polyethylenimine (PMeOx‐co‐PEI) copolymers differing by degree of polymerization (DP = 50 and 200) and PEI content (from 37 to 99 mol%) were synthesized by living cationic ring‐opening polymerization of 2‐methyl‐2‐oxazoline, followed by partial hydrolysis. Upon mixing with DNA in a wide range of N/P ratios, they formed well‐defined polyplex particles of small size (typically below 100 nm) and narrow size distribution. The polyplexes demonstrated good colloidal stability and very low in vitro cytotoxicity. The copolymers exhibited buffering capacity of over 50% relative to that of the reference PEI implying effective endo‐lysosomal escape of the polyplexes. Increased cellular internalization of both PCR fragments and plasmid DNA, attributable to the strongly positive ζ potential and small size of the polyplexes, was observed. In spite of these favorable prerequisites, the transfection efficiency was low (below 20% relative to the control PEI) and was attributed to retarded swelling of the polyplex particles, endo‐lysosomal rupture, and DNA release.

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“…Quaternized chitins vector synthesized via eco-friendly process [135] Organosilane-functionalized chitosan nanoparticles as plox plasmid delivery system [136] Chitosan-graft-PEI-PEG gene carrier decorated with arginine-glycine-aspartate/twin-arginine translocation for sustained delivery of NT-3 protein growth factor for neural regeneration [137] Targeting ligand conjugated chitosan-PEI copolymer/siRNA polyplexes for cancer therapy [138] Liposome encapsulated chitosan nanoparticles for enhanced plasmid DNAdelivery [139] Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 6 May 2019 doi:10.20944/preprints201905.0066.v1…”

Section: Tissue Engineeringmentioning

confidence: 99%

Chitin and Chitosans: Characteristics, Eco-Friendly Processes and Applications in Cosmetic Science

Casadidio

Peregrina

Gigliobianco

et al. 2019

Preprint

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Huge amounts of chitin and chitosans can be found in the biosphere as important constituent of the exoskeleton of many organisms, as well as waste by worldwide seafood companies. Nowadays, politicians, environmentalists, and industrialists encouraged the use of these marine polysaccharides as renewable source, particularly when developed by alternative eco-friendly processes, especially in the production of regular cosmetics. The aim of this review is to outline the physicochemical and biological properties and the different bioextraction methods of chitin and chitosans sources, focusing on enzymatic deproteinization, bacteria fermentation, and enzymatic deacetylation methods. Thanks to their biodegradability, non-toxicity, biocompatibility, and bioactivity, the application of these marine polymers is widely used in the contemporary manufacturing of biomedical and pharmaceutical products. In the end, advanced cosmetic products based on chitin and chitosans are presented, analyzing different therapeutic aspects about skin, hair, nail, and oral care. The innovative formulations described can be considered as excellent solutions regarding problems in the various body anatomical sectors.

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Target gene delivery from targeting ligand conjugated chitosan–PEI copolymer for cancer therapy

Cited by 75 publications

References 37 publications

Modification of Chitosan for the Generation of Functional Derivatives

Modification of Chitosan for the Generation of Functional Derivatives

DNA delivery systems based on copolymers of poly (2‐methyl‐2‐oxazoline) and polyethyleneimine: Effect of polyoxazoline moieties on the endo‐lysosomal escape

Chitin and Chitosans: Characteristics, Eco-Friendly Processes and Applications in Cosmetic Science

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