2002
DOI: 10.1097/00000539-200205000-00030
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Target-Controlled Versus Manually-Controlled Infusion of Propofol for Direct Laryngoscopy and Bronchoscopy

Abstract: This study compares the clinical profile of propofol anesthesia for direct laryngoscopy with spontaneous ventilation when the drug is administered either as a manually controlled infusion or by targeting the effect-site concentration through a target-controlled infusion (TCI) device. TCI improves the time course of propofol effects.

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Cited by 94 publications
(59 citation statements)
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“…19 Contrary to the patients with respiratory depression in Group P, three patients in Group R with respiratory depression could be verbally stimulated by the anesthesiologist when oxygen saturation was decreasing. However, the higher PaCO 2 values in Group P compared to Group R are at variance with others studies, 15,17,[20][21][22] and can be explained by higher doses of propofol administered in our investigation. Blood gas disturbances at the end of the procedure could also be partially responsible for the prolonged recovery time observed in Group P, although average procedural and anesthetic times were comparable in the two groups.…”
Section: Discussioncontrasting
confidence: 87%
See 1 more Smart Citation
“…19 Contrary to the patients with respiratory depression in Group P, three patients in Group R with respiratory depression could be verbally stimulated by the anesthesiologist when oxygen saturation was decreasing. However, the higher PaCO 2 values in Group P compared to Group R are at variance with others studies, 15,17,[20][21][22] and can be explained by higher doses of propofol administered in our investigation. Blood gas disturbances at the end of the procedure could also be partially responsible for the prolonged recovery time observed in Group P, although average procedural and anesthetic times were comparable in the two groups.…”
Section: Discussioncontrasting
confidence: 87%
“…**P < 0.01 T1 vs T2 for R and P. **P < 0.01 P vs R at T2. In Group P, agitation that could have hampered the procedure 15 was not observed at the achieved level of sedation. However, agitation has been reported by Newson et al 16 during mammary biopsy under propofol and local anesthesia.…”
Section: Discussionmentioning
confidence: 89%
“…(17) When administered with a plasma target model, TCI could lead to more stable haemodynamic parameters. (18) Currently, most patients undergoing bronchoscopy receive MS with a different regimen than the one used in the present study. (2) It is difficult for anaesthesiologists and bronchoscopists to find a balance between MS and sufficient oxygenation due to individual differences among patients.…”
Section: Discussionmentioning
confidence: 99%
“…33 In our patient the anesthetic protocol consisted of intravenous target-controlled infusion of propofol with opioid supplementation, with a low concentration of remifentanil to ensure spontaneous ventilation throughout the procedure. 34 Patients with large-airway obstruction may not be able to endure the supine position during anesthetic induction, so the induction is carried out with the patient semirecumbent. Once the patient loses consciousness, he is positioned supine and the rigid bronchoscope is introduced.…”
Section: Discussionmentioning
confidence: 99%